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Title:           Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial
Subject:         Trials, https://doi.org/10.1186/s13063-025-08838-2
Keywords:        Ventilator-induced diaphragm dysfunction;Phrenic nerve stimulation;Ultrasonography;Mechanical ventilation;Critical illness;Critical care;Diaphragm;Phrenic nerve
Author:           Annia F. Schreiber 
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     Item: 
      Title: Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Discussion 
         Item: 
          Title: Trial registration 
       Item: 
        Title: Administrative information
       Item: 
        Title: Introduction
        Children: 
         Item: 
          Title: Background and rationale {6a}
         Item: 
          Title: Objectives {7}
         Item: 
          Title: Trial design {8}
       Item: 
        Title: Methods: participants, interventions and outcomes
        Children: 
         Item: 
          Title: Study setting {9}
         Item: 
          Title: Eligibility criteria {10}
         Item: 
          Title: Who will take informed consent? {26a}
         Item: 
          Title: Additional consent provisions for collection and use of participant data and biological specimens {26b}
       Item: 
        Title: Interventions
        Children: 
         Item: 
          Title: Explanation for the choice of comparators {6b}
         Item: 
          Title: Intervention description {11a}
         Item: 
          Title: Criteria for discontinuing or modifying allocated interventions {11b}
         Item: 
          Title: Strategies to improve adherence to interventions {11c}
         Item: 
          Title: Relevant concomitant care permitted or prohibited during the trial {11 d}
         Item: 
          Title: Provisions for post-trial care {30}
         Item: 
          Title: Outcomes {12}
          Children: 
           Item: 
            Title: Primary outcome
           Item: 
            Title: Secondary outcomes
           Item: 
            Title: Other outcomes
         Item: 
          Title: Participant timeline {13}
         Item: 
          Title: Sample size {14}
         Item: 
          Title: Recruitment {15}
       Item: 
        Title: Assignment of interventions: allocation
        Children: 
         Item: 
          Title: Sequence generation {16a}
         Item: 
          Title: Concealment mechanism {16b}
         Item: 
          Title: Implementation {16c}
       Item: 
        Title: Assignment of interventions: blinding
        Children: 
         Item: 
          Title: What will be blinded {17a}
         Item: 
          Title: Procedure for unblinding if needed {17b}
       Item: 
        Title: Data collection and management
        Children: 
         Item: 
          Title: Plans for assessment and collection of outcomes {18a}
          Children: 
           Item: 
            Title: Primary outcome
           Item: 
            Title: Secondary outcomes and other outcomes
         Item: 
          Title: Plans to promote participant retention and complete follow-up {18b}
         Item: 
          Title: Data management {19}
         Item: 
          Title: Confidentiality {27}
         Item: 
          Title: Plans for collection, laboratory evaluation, and storage of biological specimens for genetic or molecular analysis in this trialfuture use {33}
       Item: 
        Title: Statistical methods
        Children: 
         Item: 
          Title: Statistical methods for primary and secondary outcomes {20a}
         Item: 
          Title: Interim analyses {21b}
         Item: 
          Title: Methods for additional analyses (e.g. subgroup analyses) {20b}
         Item: 
          Title: Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
         Item: 
          Title: Missing at random
          Children: 
           Item: 
            Title: Missing for cause
       Item: 
        Title: Sensitivity analyses
        Children: 
         Item: 
          Title: Plans to give access to the full protocol, participant-leveldata and statistical code {31c}
       Item: 
        Title: Oversight and monitoring
        Children: 
         Item: 
          Title: Composition of the coordinating center and trial steering committee {5d}
       Item: 
        Title: Legal manufacturer and sponsor
       Item: 
        Title: International principal investigator and international study coordinationtraining
       Item: 
        Title: Site lead investigator and site research team
       Item: 
        Title: Steering committee
       Item: 
        Title: Clinical event committee (CEC)
        Children: 
         Item: 
          Title: Composition of the data monitoring committee, its role and reporting structure {21a}
         Item: 
          Title: Adverse event reporting and harms {22}
          Children: 
           Item: 
            Title: SAE device-related
           Item: 
            Title: SAE procedure-related
           Item: 
            Title: Adverse event reporting to IRBEC and regulatory agencies for unanticipated device events
           Item: 
            Title: Patient death
         Item: 
          Title: Frequency and plans for auditing trial conduct {23}
         Item: 
          Title: Plans for communicating important protocol amendments to relevant parties (e.g. trial participants, ethical committees) {25}
         Item: 
          Title: Dissemination plans {31a}
       Item: 
        Title: Discussion
       Item: 
        Title: Trial status
       Item: 
        Title: References
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                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary."
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). "
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version."
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Volume number"
                  pdfaProperty:name="volume"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Issue number"
                  pdfaProperty:name="number"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Starting page"
                  pdfaProperty:name="startingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Ending page"
                  pdfaProperty:name="endingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. "
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                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright"
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
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              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
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            </rdf:Description>
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              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
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              pdfaSchema:schema="XMP Media Management Schema">
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                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="DocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
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                <rdf:li
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                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
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          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
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                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
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          <rdf:li>
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              pdfaSchema:schema="Springer Nature ORCID Schema"
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn">
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                <rdf:li
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                  pdfaProperty:valueType="Bag AuthorInformation"
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."/>
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            <pdfaSchema:valueType>
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                <rdf:li>
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                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author.">
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                        pdfaField:valueType="Text"
                        pdfaField:description="Gives the name of an author."/>
                      <rdf:li
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"
                        pdfaField:description="Gives the ORCID of an author."/>
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