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Title:           Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
Subject:         Nature Communications, doi:10.1038/s41467-025-61054-z
Keywords:        
Author:          Laia Montoliu-Gaya
Creator:         Springer
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      Title: Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
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        Title: Results
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         Item: 
          Title: Most proteomic changes in DS CSF occur prior to the onset of AD symptoms
          Destination: B1
         Item: 
          Title: Identification of systems pathological changes in DS using protein co-expression
          Destination: B2
         Item: 
          Title: Many protein co-expression modules in DS are altered prior to decreases in CSF Aβ42/40
          Destination: B3
         Item: 
          Title: Comparison of individual protein measures in DS to ADAD highlights common alterations but unique temporal patterns
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         Item: 
          Title: Comparison of DS CSF and brain proteomes reveals concordant and discordant alterations between compartments
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        Title: Discussion
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        Title: Methods
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          Title: Study design and participants
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         Item: 
          Title: Ethics
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         Item: 
          Title: Sample collection and measurement of CSF Alzheimer´s disease biomarkers
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         Item: 
          Title: CSF digestion and tandem mass Tag (TMT) peptide labeling
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         Item: 
          Title: Off-line fractionation
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         Item: 
          Title: LC-MS analysis
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         Item: 
          Title: Proteomic data analysis
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         Item: 
          Title: Protein abundance data processing
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         Item: 
          Title: Bayesian modeling
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         Item: 
          Title: Differential expression analysis
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         Item: 
          Title: Protein co-expression network analysis
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         Item: 
          Title: Ontology enrichment
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         Item: 
          Title: Cell type marker enrichment analyses
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         Item: 
          Title: Synthetic eigenprotein analysis
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         Item: 
          Title: Immunohistochemistry
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          Title: Other statistics and graphic visualization
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          Title: Reporting summary
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        Title: References
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       Item: 
        Title: Competing interests
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    Subject: Nature Communications, doi:10.1038/s41467-025-61054-z
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