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Endocrinol. 16:1699111. doi: 10.3389/fendo.2025.1699111 Keywords: type 1 diabetes mellitus; thyroid autoimmunity; thyroid peroxidase (TPO) antibodies; thyroid dysfunction; age-related screening strategy Author: Gemma Carreras CreationDate: Wed Oct 29 09:40:12 2025 CET ModDate: Wed Oct 29 09:40:12 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 671121 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DNGPEK+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 147 0 DNGPEL+AdvPSA18C Type 1C WinAnsi yes yes no 478 0 DNGPEM+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 149 0 DNGPEN+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 145 0 DNGPEO+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 150 0 DNGPEP+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 340 0 DNGPFA+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 341 0 DNHFDM+AdvPSA323 Type 1C WinAnsi yes yes no 479 0 DNHFEN+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 480 0 DNHFIM+AdvOT1ef757c0 Type 1C Custom yes yes yes 141 0 DNHFIN+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 144 0 DNHFJO+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 143 0 DNHFLO+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 490 0 DNHFOO+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 142 0 DNHFOP+AdvTT2c8ce45a+22 Type 1C Custom yes yes yes 146 0 DNHFPA+AdvTTd3a5f740+22 Type 1C Custom yes yes yes 148 0 DNHMJI+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 511 0 DNIEKI+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 515 0 DNIELI+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 516 0 DNIELJ+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 517 0 DNIELK+AdvTT58d178b9+03 Type 1C Custom yes yes yes 518 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-28 04:12:04 CET RepresentationInformation: 326224.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-27 09:39:52 CET Size: 671121 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 586 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study Destination: bmark_409761648 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Methods Destination: s2 Children: Item: Title: 2.1 Study design and patients Destination: s2_1 Item: Title: 2.2 Ethics statement Destination: s2_2 Item: Title: 2.3 Assessments Destination: s2_3 Item: Title: 2.4 Statistical analysis Destination: s2_4 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Cohort characteristics and thyroid dysfunction by TPO-Abs status Destination: s3_1 Item: Title: 3.2 Effect of age at diabetes onset on thyroid outcomes Destination: s3_2 Item: Title: 4 Discussion Destination: s4 Children: Item: Title: 4.1 Main findings Destination: s4_1 Item: Title: 4.2 Thyroid autoimmunity as a determinant of thyroid dysfunction Destination: s4_2 Item: Title: 4.3 Predictive value of TPO-Abs at diagnosis Destination: s4_3 Item: Title: 4.4 Screening implications in youth Destination: s4_4 Item: Title: 4.5 Screening implications in adults Destination: s4_5 Item: Title: 4.6 Strengths and limitations Destination: s4_6 Item: Title: 4.7 Proposed screening strategy Destination: s4_7 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study Author: Gemma Carreras Subject: Carreras G, Mendoza LC, Colom C, Tirado-Capistros M, Sardà H, Sánchez-Quesada JL and Pérez A (2025) Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study. Front. 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Mendoza Cristina Colom Mireia Tirado-Capistros Helena Sardà José Luis Sánchez-Quesada Antonio Pérez Carreras G, Mendoza LC, Colom C, Tirado-Capistros M, Sardà H, Sánchez-Quesada JL and Pérez A (2025) Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study. Front. Endocrinol. 16:1699111. doi: 10.3389/fendo.2025.1699111 Copyright © 2025 Carreras, Mendoza, Colom, Tirado-Capistros, Sardà, Sánchez-Quesada and Pérez.. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. type 1 diabetes mellitus thyroid autoimmunity thyroid peroxidase (TPO) antibodies thyroid dysfunction age-related screening strategy Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study type 1 diabetes mellitus; thyroid autoimmunity; thyroid peroxidase (TPO) antibodies; thyroid dysfunction; age-related screening strategy True https://www.frontiersin.org/legal/copyright-statement 2025-10-29T16:40:12+08:00 2025-10-29T16:40:12+08:00 2025-10-29T16:40:12+08:00 uuid:efe9424c-9908-47eb-9d7c-e7ebe27b1471 uuid:a411baf7-d1aa-4809-80ea-e857dc805db1 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 521, 706 Annotation: Subtype: Link Rect: 221, 660, 532, 681 Annotation: Subtype: Link Rect: 221, 635, 448, 656 Annotation: Subtype: Link Rect: 221, 610, 483, 631 Annotation: Subtype: Link Rect: 221, 585, 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