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Title:           Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease
Subject:         ​Riberas-Sánchez A, ​García-Brito S, ​Vila-Solés L, ​Aldavert-Vera L, ​Segura-Torres P, Huguet G, ​Carreras-Badosa G and Kádár E (2025) Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease. Front. Aging Neurosci. 17:1671196. doi: 10.3389/fnagi.2025.1671196
Author:          Andrea Riberas-Sánchez
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     Item: 
      Title: Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Animals
         Item: 
          Title: Experimental groups
         Item: 
          Title: Intracerebroventricular injection of STZ and electrode implantation
         Item: 
          Title: Intracranial self-stimulation treatment
         Item: 
          Title: Morris water maze
         Item: 
          Title: Animal sample collection
         Item: 
          Title: In vitro assessments in the human neuroblastoma SH-SY5Y cell line
         Item: 
          Title: TaqMan miRNA qRT-PCR
         Item: 
          Title: TaqMan mRNA qRT-PCR
         Item: 
          Title: Western blot
         Item: 
          Title: Nissl staining
         Item: 
          Title: NRF2 immunostaining
         Item: 
          Title: Statistical analyses
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: MFB-ICSS treatment improved performance on the spatial MWM task 5 months after STZ infusion
         Item: 
          Title: Serum miRNA levels were altered at 29 days after STZ administration
         Item: 
          Title: Serum miRNA levels at 29 days after STZ administration were associated with worse spatial memory performance in the MWM task 5 months after STZ administration
         Item: 
          Title: The 5-month time-course of the miR-495 and miR-146a serum levels differed in MFB-ICSS treated vs. untreated STZ rats
         Item: 
          Title: Overexpression of miRNA-495 downregulated mRNA and protein NRF2 levels in human neuroblastoma SH-SY5Y cells
         Item: 
          Title: MFB-ICSS modified NRF2 levels in the hippocampal CA1 region in treated STZ rats
         Item: 
          Title: MFB-ICSS treated STZ rats exhibited increased thickness of corpus callosum compared to untreated STZ rats
       Item: 
        Title: Discussion
     Item: 
      Title: References
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    Title: Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease
    Author: Andrea Riberas-Sánchez
    Subject: ​Riberas-Sánchez A, ​García-Brito S, ​Vila-Solés L, ​Aldavert-Vera L, ​Segura-Torres P, Huguet G, ​Carreras-Badosa G and Kádár E (2025) Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restore猀 栀椀瀀瀀漀挀愀洀瀀愀氀 一刀䘀㈀ 氀攀瘀攀氀猀 椀渀 愀 爀愀琀 洀漀搀攀氀 漀昀 猀瀀漀爀愀搀椀挀 䄀氀稀栀攀椀洀攀爠ᤀ猀 搀椀猀攀愀猀攀⸀ 䘀爀漀渀琀⸀ 䄀最椀渀最 一攀甀爀漀猀挀椀⸀ ㄀㜀㨀㄀㘀㜀㄀㄀㤀㘀⸀ 搀漀椀㨀 ㄀　⸀㌀㌀㠀㤀⼀昀渀愀最椀2025.1671196
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