c077eae81f4a68c06de0a28aca89082d 326409.pdf 1f2f8d8cdc1cd3820822407b16788288f40cdc66 326409.pdf 9341e8a46ff3f30e151101fcd1033c9ab557770ba4743eaae91254b563a99197 326409.pdf Title: Effects of Turmeric and Turmeric Plus Piperine Supplementation on Lipid Profiles in Adults with Cardiometabolic Risk Conditions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Following PRISMA Guidelines Subject: Background: Turmeric (Curcuma longa) and its main bioactive compound curcumin are widely promoted for cardiometabolic health, yet their efficacy on lipid parameters remains uncertain. Piperine, an alkaloid from black pepper, enhances curcumin bioavailability and may potentiate its effects. This systematic review and meta-analysis aimed to assess the impact of turmeric, alone or combined with piperine, on lipid profiles in adults with metabolic disorders. Methods: A systematic search was conducted (2010–2025) in PubMed, Scopus, and Cochrane CENTRAL. Randomized controlled trials (RCTs) evaluating turmeric supplementation (with or without piperine) on lipid outcomes were included. Methodological quality was assessed with Cochrane RoB 2; certainty of evidence was rated using GRADE. Meta-analyses were performed with random-effects models. The protocol followed PRISMA 2020 guidelines. Results: Ten records were identified; six full texts were assessed; three RCTs (n 250) were included in quantitative synthesis, and three additional RCTs narratively. Pooled analysis demonstrated significant reductions in triglycerides (WMD -25.5 mg/dL, 95% CI -32.5 to -18.4), total cholesterol (-14.1 mg/dL, 95% CI -22.9 to -5.3), and LDL-C (-17.0 mg/dL, 95% CI -25.2 to -8.8), with an increase in HDL-C (+5.7 mg/dL, 95% CI +2.0 to +9.4). Subgroup analysis suggested greater LDL-C reduction with turmeric+piperine (-29.6 mg/dL) compared to turmeric alone (-16.2 mg/dL). Certainty of evidence was moderate for TG, TC, LDL-C, and low for HDL-C. Conclusions: Turmeric supplementation, particularly when combined with piperine, improves lipid profiles in adults with metabolic disorders. These effects are clinically relevant and comparable to other nutraceuticals, although evidence remains limited by short trial duration and small sample sizes. Larger, long-term RCTs are warranted before turmeric can be recommended in evidence-based dyslipidemia guidelines. Keywords: turmeric; curcumin; piperine; lipid profile; dyslipidemia; nutraceuticals; meta-analysis; PRISMA Author: Francisco Epelde Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Mon Dec 15 11:01:17 2025 CET ModDate: Mon Dec 15 11:05:38 2025 CET Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1256096 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MIKRSI+VnURWPalladioL Type 1 Custom yes yes yes 168 0 WGVPRK+URWPalladioL-Roma Type 1 Custom yes yes yes 169 0 JNWJGR+URWPalladioL-Ital Type 1 Custom yes yes yes 170 0 XCNVSI+URWPalladioL-Bold Type 1 Custom yes yes yes 171 0 BTFZDJ+CMSY10 Type 1 Builtin yes yes yes 172 0 NILAHE+Arial TrueType WinAnsi yes yes no 258 0 NIKPNC+PalatinoLinotype TrueType WinAnsi yes yes no 259 0 NIKPNC+PalatinoLinotype TrueType WinAnsi yes yes no 332 0 NIKPNC+PalatinoLinotype TrueType WinAnsi yes yes no 324 0 YMRPRH+EURM10 Type 1 Builtin yes yes yes 373 0 NIKPNC+PalatinoLinotype TrueType WinAnsi yes yes no 348 0 NIKPNC+PalatinoLinotype TrueType WinAnsi yes yes no 340 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-04-09 04:01:34 CEST RepresentationInformation: 326409.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-04-08 11:01:30 CEST Size: 1256096 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 629 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Protocol and Reporting Item: Title: Eligibility Criteria Item: Title: Information Sources and Search Strategy Item: Title: Study Selection Item: Title: Data Collection Process Item: Title: Risk of Bias in Individual Studies Item: Title: Effect Measures and Synthesis Item: Title: Certainty of Evidence Item: Title: Results Children: Item: Title: Study Results Item: Title: Study Characteristics Item: Title: Risk of Bias Item: Title: Pooled Effects on Lipid Profile Item: Title: Subgroup Analysis Item: Title: Non-Meta-Analyzable Evidence Item: Title: Certainty of Evidence (Grade) Item: Title: Safety and Adverse Events Item: Title: Discussion Children: Item: Title: Interpretation of Findings in the Context of Nutraceuticals Item: Title: Comparison with Previous Reviews and Meta-Analyses Item: Title: Mechanistic Insights Item: Title: Clinical Significance Item: Title: Strengths of This Review Item: Title: Limitations Item: Title: Integration with Broader Literature Item: Title: Future Research Directions Item: Title: Summary of Evidence Item: Title: References Info: Title: Effects of Turmeric and Turmeric Plus Piperine Supplementation on Lipid Profiles in Adults with Cardiometabolic Risk Conditions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Following PRISMA Guidelines Author: Francisco Epelde Subject: Background: Turmeric (Curcuma longa) and its main bioactive compound curcumin are widely promoted for cardiometabolic health, yet their efficacy on lipid parameters remains uncertain. Piperine, an alkaloid from black pepper, enhances curcumin bioavailability and may potentiate its effects. This systematic review and meta-analysis aimed to assess the impact of turmeric, alone or combined with piperine, on lipid profiles in adults with metabolic disorders. Methods: A systematic search was conducted (2010–2025) in PubMed, Scopus, and Cochrane CENTRAL. Randomized controlled trials (RCTs) evaluating turmeric supplementation (with or without piperine) on lipid outcomes were included. Methodological quality was assessed with Cochrane RoB 2; certainty of evidence was rated using GRADE. Meta-analyses were performed with random-effects models. The protocol followed PRISMA 2020 guidelines. Results: Ten records were identified; six full texts were assessed; three RCTs (n 250) were included in quantitative synthesis, and three additional RCTs narratively. Pooled analysis demonstrated significant reductions in triglycerides (WMD -25.5 mg/dL, 95% CI -32.5 to -18.4), total cholesterol (-14.1 mg/dL, 95% CI -22.9 to -5.3), and LDL-C (-17.0 mg/dL, 95% CI -25.2 to -8.8), with an increase in HDL-C (+5.7 mg/dL, 95% CI +2.0 to +9.4). Subgroup analysis suggested greater LDL-C reduction with turmeric+piperine (-29.6 mg/dL) compared to turmeric alone (-16.2 mg/dL). Certainty of evidence was moderate for TG, TC, LDL-C, and low for HDL-C. Conclusions: Turmeric supplementation, particularly when combined with piperine, improves lipid profiles in adults with metabolic disorders. These effects are clinically relevant and comparable to other nutraceuticals, although evidence remains limited by short trial duration and small sample sizes. Larger, long-term RCTs are warranted before turmeric can be recommended in evidence-based dyslipidemia guidelines. 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