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Title:           Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure
Subject:         DOI: 10.1093/eurheartj/ehaf605; European Heart Journal, 46, 48, 2025-08-29.; Abstract:  Background and aims: Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM patients with high-risk arrhythmic genotypes also develop more advanced heart failure (AHF) complications. AHF events were studied according to DCM genotype. Methods: Clinical data from 1203 genotyped DCM patients were collected from 19 Spanish centres. Patients were classified into high-risk arrhythmic genotypes (LMNA, FLNC, desmosomal genes, PLN, TMEM43, RBM20), TTN, other genes, and genotype negative (Gen−). The primary endpoint was a composite of AHF events (ventricular assist device implantation, heart transplant, and AHF-related mortality). The secondary endpoint was a combination of malignant ventricular arrhythmias (MVA). Results: A DCM-causing variant was identified in a high-risk arrhythmic gene in 185 patients (15.4%), 193 (16.0%) had variants in TTN, 134
Keywords:        Dilated cardiomyopathy; Genes; Heart failure; Sudden cardiac death; Prognosis
Author:          Nerea Mora-Ayestarán
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      Title: Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure
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        Title: Introduction
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        Title: Methods
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          Title: Study population
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          Title: Genotype as a predictor of AHF outcomes
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          Title: Genotype as a predictor of arrhythmic outcomes
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  Checksum: a54957ee
   Type: CRC32
  Checksum: b4dcbb7256e8f9e0a22aa3b6f32a4a3e
   Type: MD5
  Checksum: 20f565544a9b99099ffde3b2d05b137ad54bbd50
   Type: SHA-1
  Checksum: 1ff683b4c06e7a7e3dca6c06e605f61721b5dfae17f76f0f3cd636df0e1135fd
   Type: SHA-256