55c93e4ced0b17f5a5f2e3eb699608c1 Clinical_Trial_Early_Nivolumab_Addition_to_Regoraf.pdf 1d05efe1565c9c599578b8c15a8b16fde7249970 Clinical_Trial_Early_Nivolumab_Addition_to_Regoraf.pdf 977069f7f9a46dab3987a4b30ab780b2777f98e3aee0735f372b2eee9a486c78 Clinical_Trial_Early_Nivolumab_Addition_to_Regoraf.pdf Title: Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second‐Line (The GOING Trial) Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Mon Feb 23 07:53:10 2026 CET ModDate: Mon Feb 23 07:53:16 2026 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 761085 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IODGUH+STIXTwoText-Italic Type 1C WinAnsi yes yes yes 423 0 MCEEYZ+STIXTwoText Type 1C Custom yes yes yes 424 0 LWKJFB+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 425 0 EFNZLP+STIXTwoText-Bold Type 1C Custom yes yes yes 426 0 SCXBZN+ArialRoundedMTBold Type 1C WinAnsi yes yes no 359 0 SCXBZN+STIX-Regular Type 1C Custom yes yes yes 248 0 PUSKJT+ArialMT Type 1C WinAnsi yes yes no 65 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-04 03:08:53 CET RepresentationInformation: Clinical_Trial_Early_Nivolumab_Addition_to_Regoraf.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-03 05:30:47 CET Size: 761085 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 441 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second-Line (The GOING Trial) Children: Item: Title: ABSTRACT Item: Title: 〱   ぼ   ぉのぴひはつふっぴどはの Item: Title: 〲   ぼ   きづぴとはつび Children: Item: Title: 〲〮〱   ぼ   ごひどちぬ〠いづびどでの〠ちのつ〠ぐちひぴどっどばちのぴび Item: Title: 〲〮〲   ぼ   ごひづちぴねづのぴ〠ちのつ〠いはびどので〠こぴひちぴづでべ Item: Title: 〲〮〳   ぼ   ぅのつばはどのぴび Item: Title: 〲〮〴   ぼ   ぅぴとどっちぬ〠ぃはのびどつづひちぴどはのび Item: Title: 〲〮〵   ぼ   こぴちぴどびぴどっちぬ〠ぁのちぬべびどび Item: Title: 〳   ぼ   げづびふぬぴび Children: Item: Title: 〳〮〱   ぼ   ぐちぴどづのぴび Item: Title: 〳〮〲   ぼ   ごひづちぴねづのぴ Item: Title: 〳〮〳   ぼ   こちてづぴべ Item: Title: 〳〮〴   ぼ   ぅててどっちっべ Item: Title: 〴   ぼ   ぃはのっぬふびどはのび Item: Title: Author Contributions Item: Title: Acknowledgements Item: Title: Funding Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Info: Title: Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second‐Line (The GOING Trial) Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Mon Feb 23 08:23:10 CET 2026 ModDate: Mon Feb 23 08:23:16 CET 2026 ID: 0x6839872a34d7c5429b8207964d3be843, 0x19e85bf6aecb6605a766c6cc52971b23 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2067 ImageHeight: 1132 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2086 ImageHeight: 1478 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: PUSKJT+ArialMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PUSKJT+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: SCXBZN+ArialRoundedMTBold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: SCXBZN+ArialRoundedMTBold Flags: Nonsymbolic FontBBox: -174, -211, 1185, 946 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IODGUH+STIXTwoText-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: IODGUH+STIXTwoText-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -362, 1298, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MCEEYZ+STIXTwoText FontSubset: true FirstChar: 29 LastChar: 252 FontDescriptor: FontName: MCEEYZ+STIXTwoText Flags: Serif, Nonsymbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCXBZN+STIX-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: SCXBZN+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LWKJFB+STIXTwoText-BoldItalic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: LWKJFB+STIXTwoText-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EFNZLP+STIXTwoText-Bold FontSubset: true FirstChar: 29 LastChar: 243 FontDescriptor: FontName: EFNZLP+STIXTwoText-Bold Flags: Serif, Nonsymbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: VoR 10.1111/apt.70578 10.1111/apt.70578 10.1111/(ISSN)1365-2036 3 Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second‐Line (The GOING Trial) Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 45, 25, 151, 14 Annotation: Subtype: Link Rect: 143, 676, 198, 661 Annotation: Subtype: Link Rect: 152, 565, 152, 552 Annotation: Subtype: Link Rect: 152, 565, 166, 552 ActionDest: 312 Annotation: Subtype: Link Rect: 166, 566, 178, 554 Annotation: Subtype: Link Rect: 236, 565, 244, 552 ActionDest: 312 Annotation: Subtype: Link Rect: 314, 565, 322, 552 ActionDest: 312 Annotation: Subtype: Link Rect: 424, 565, 438, 552 ActionDest: 312 Annotation: Subtype: Link Rect: 499, 565, 512, 552 ActionDest: 312 Annotation: Subtype: Link Rect: 512, 566, 524, 554 Annotation: Subtype: Link Rect: 136, 554, 144, 541 ActionDest: 312 Annotation: Subtype: Link Rect: 215, 554, 226, 541 ActionDest: 312 Annotation: Subtype: Link Rect: 226, 555, 238, 543 Annotation: Subtype: Link Rect: 313, 554, 333, 541 ActionDest: 312 Annotation: Subtype: Link Rect: 391, 554, 412, 541 ActionDest: 312 Annotation: Subtype: Link Rect: 412, 555, 425, 543 Annotation: Subtype: Link Rect: 495, 554, 498, 541 ActionDest: 312 Annotation: Subtype: Link Rect: 114, 543, 122, 530 ActionDest: 312 Annotation: Subtype: Link Rect: 122, 544, 134, 532 Annotation: Subtype: Link Rect: 200, 543, 213, 530 ActionDest: 312 Annotation: Subtype: Link Rect: 315, 543, 318, 530 ActionDest: 312 Annotation: Subtype: Link Rect: 385, 543, 388, 530 ActionDest: 312 Annotation: Subtype: Link Rect: 456, 543, 469, 530 ActionDest: 312 Annotation: Subtype: Link Rect: 469, 544, 481, 532 Annotation: Subtype: Link Rect: 94, 532, 105, 519 ActionDest: 312 Annotation: Subtype: Link Rect: 204, 532, 223, 519 ActionDest: 312 Annotation: Subtype: Link Rect: 301, 532, 307, 519 ActionDest: 312 Annotation: Subtype: Link Rect: 371, 532, 393, 519 ActionDest: 312 Annotation: Subtype: Link Rect: 482, 532, 496, 519 ActionDest: 312 Annotation: Subtype: Link Rect: 90, 521, 93, 508 ActionDest: 312 Annotation: Subtype: Link Rect: 160, 521, 163, 508 ActionDest: 312 Annotation: Subtype: Link Rect: 226, 521, 232, 508 ActionDest: 312 Annotation: Subtype: Link Rect: 286, 521, 294, 508 ActionDest: 312 Annotation: Subtype: Link Rect: 348, 521, 348, 508 Annotation: Subtype: Link Rect: 348, 521, 369, 508 ActionDest: 312 Annotation: Subtype: Link Rect: 202, 367, 273, 356 Annotation: Subtype: Link Rect: 325, 367, 383, 356 Annotation: Subtype: Link Rect: 202, 78, 349, 68 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 271, 663, 410, 650 Annotation: Subtype: Link Rect: 47, 583, 60, 570 ActionDest: 132 Annotation: Subtype: Link Rect: 231, 560, 244, 547 ActionDest: 132 Annotation: Subtype: Link Rect: 80, 502, 84, 490 ActionDest: 132 Annotation: Subtype: Link Rect: 242, 387, 264, 375 ActionDest: 132 Annotation: Subtype: Link Rect: 165, 307, 174, 294 ActionDest: 132 Annotation: Subtype: Link Rect: 79, 284, 87, 271 ActionDest: 132 Annotation: Subtype: Link Rect: 80, 249, 89, 237 ActionDest: 132 Annotation: Subtype: Link Rect: 367, 594, 375, 582 ActionDest: 132 Annotation: Subtype: Link Rect: 450, 491, 458, 478 ActionDest: 132 Annotation: Subtype: Link Rect: 334, 134, 339, 122 ActionDest: 25 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 244, 348, 248, 335 ActionDest: 25 Annotation: Subtype: Link Rect: 148, 176, 156, 163 ActionDest: 132 Annotation: Subtype: Link Rect: 81, 72, 90, 59 ActionDest: 132 Annotation: Subtype: Link Rect: 380, 314, 389, 301 ActionDest: 132 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 69, 705, 78, 693 ActionDest: 232 Annotation: Subtype: Link Rect: 221, 521, 229, 509 ActionDest: 132 Annotation: Subtype: Link Rect: 48, 510, 57, 497 ActionDest: 132 Annotation: Subtype: Link Rect: 126, 510, 135, 497 ActionDest: 132 Annotation: Subtype: Link Rect: 170, 314, 178, 302 ActionDest: 132 Annotation: Subtype: Link Rect: 48, 303, 57, 290 ActionDest: 132 Annotation: Subtype: Link Rect: 337, 705, 341, 693 ActionDest: 61 Annotation: Subtype: Link Rect: 463, 671, 467, 658 ActionDest: 72 Annotation: Subtype: Link Rect: 332, 234, 340, 221 ActionDest: 232 Annotation: Subtype: Link Rect: 332, 165, 336, 152 ActionDest: 82 Annotation: Subtype: Link Rect: 331, 73, 335, 60 ActionDest: 104 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 280, 61, 289, 48 ActionDest: 232 Annotation: Subtype: Link Rect: 388, 142, 397, 129 ActionDest: 232 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 76, 564, 80, 551 ActionDest: 72 Annotation: Subtype: Link Rect: 139, 547, 146, 535 ActionDest: 72 Annotation: Subtype: Link Rect: 95, 497, 106, 484 ActionDest: 72 Annotation: Subtype: Link Rect: 136, 379, 139, 366 ActionDest: 72 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 435, 740, 444, 727 ActionDest: 232 Annotation: Subtype: Link Rect: 336, 717, 340, 704 ActionDest: 116 Annotation: Subtype: Link Rect: 496, 648, 509, 635 ActionDest: 232 Annotation: Subtype: Link Rect: 362, 613, 375, 601 ActionDest: 232 Annotation: Subtype: Link Rect: 394, 431, 403, 419 ActionDest: 132 Annotation: Subtype: Link Rect: 361, 408, 370, 396 ActionDest: 132 Annotation: Subtype: Link Rect: 374, 213, 383, 200 ActionDest: 132 Annotation: Subtype: Link Rect: 403, 155, 412, 143 ActionDest: 132 Annotation: Subtype: Link Rect: 117, 506, 120, 493 ActionDest: 82 Annotation: Subtype: Link Rect: 117, 466, 120, 453 ActionDest: 82 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 277, 210, 286, 197 ActionDest: 132 Annotation: Subtype: Link Rect: 103, 130, 112, 117 ActionDest: 132 Annotation: Subtype: Link Rect: 179, 130, 188, 117 ActionDest: 132 Annotation: Subtype: Link Rect: 308, 245, 317, 232 ActionDest: 132 Annotation: Subtype: Link Rect: 329, 751, 332, 739 ActionDest: 104 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 264, 268, 273, 255 ActionDest: 132 Annotation: Subtype: Link Rect: 47, 96, 69, 83 ActionDest: 132 Annotation: Subtype: Link Rect: 67, 61, 76, 48 ActionDest: 132 Annotation: Subtype: Link Rect: 331, 130, 339, 117 ActionDest: 232 Annotation: Subtype: Link Rect: 379, 96, 402, 83 ActionDest: 232 Page: Sequence: 10 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 203, 715, 289, 704 Annotation: Subtype: Link Rect: 45, 705, 106, 694 Annotation: Subtype: Link Rect: 188, 670, 289, 658 Annotation: Subtype: Link Rect: 45, 660, 86, 648 Annotation: Subtype: Link Rect: 182, 624, 289, 613 Annotation: Subtype: Link Rect: 45, 614, 76, 603 Annotation: Subtype: Link Rect: 129, 579, 271, 568 Annotation: Subtype: Link Rect: 251, 544, 289, 532 Annotation: Subtype: Link Rect: 45, 534, 176, 522 Annotation: Subtype: Link Rect: 227, 488, 289, 477 Annotation: Subtype: Link Rect: 45, 478, 144, 467 Annotation: Subtype: Link Rect: 45, 423, 205, 412 Annotation: Subtype: Link Rect: 189, 378, 289, 366 Annotation: Subtype: Link Rect: 45, 368, 103, 356 Annotation: Subtype: Link Rect: 127, 332, 273, 321 Annotation: Subtype: Link Rect: 237, 307, 289, 296 Annotation: Subtype: Link Rect: 45, 297, 132, 286 Annotation: Subtype: Link Rect: 178, 262, 289, 251 Annotation: Subtype: Link Rect: 45, 252, 129, 241 Annotation: Subtype: Link Rect: 167, 217, 289, 205 Annotation: Subtype: Link Rect: 45, 207, 68, 195 Annotation: Subtype: Link Rect: 208, 161, 289, 150 Annotation: Subtype: Link Rect: 45, 151, 82, 140 Annotation: Subtype: Link Rect: 78, 106, 230, 95 Annotation: Subtype: Link Rect: 227, 71, 289, 59 Annotation: Subtype: Link Rect: 45, 61, 132, 49 Annotation: Subtype: Link Rect: 449, 721, 549, 710 Annotation: Subtype: Link Rect: 306, 711, 364, 700 Annotation: Subtype: Link Rect: 512, 686, 549, 675 Annotation: Subtype: Link Rect: 306, 676, 384, 665 Annotation: Subtype: Link Rect: 339, 651, 549, 640 Annotation: Subtype: Link Rect: 306, 641, 485, 630 Annotation: Subtype: Link Rect: 512, 606, 549, 595 Annotation: Subtype: Link Rect: 306, 596, 385, 585 Annotation: Subtype: Link Rect: 512, 561, 549, 550 Annotation: Subtype: Link Rect: 306, 551, 407, 540 Annotation: Subtype: Link Rect: 383, 496, 545, 485 Annotation: Subtype: Link Rect: 469, 451, 549, 440 Annotation: Subtype: Link Rect: 306, 441, 385, 430 Annotation: Subtype: Link Rect: 338, 386, 491, 375 Annotation: Subtype: Link Rect: 326, 341, 466, 330 Annotation: Subtype: Link Rect: 488, 296, 549, 285 Annotation: Subtype: Link Rect: 306, 286, 371, 275 Annotation: Subtype: Link Rect: 364, 241, 506, 230 Annotation: Subtype: Link Rect: 449, 196, 549, 185 Annotation: Subtype: Link Rect: 306, 186, 347, 175 Annotation: Subtype: Link Rect: 338, 141, 479, 130 Annotation: Subtype: Link Rect: 512, 96, 549, 85 Annotation: Subtype: Link Rect: 306, 86, 410, 75 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 263, 731, 289, 720 Annotation: Subtype: Link Rect: 45, 721, 188, 710 Annotation: Subtype: Link Rect: 237, 686, 289, 675 Annotation: Subtype: Link Rect: 45, 676, 143, 665 Annotation: Subtype: Link Rect: 120, 631, 269, 620 Annotation: Subtype: Link Rect: 166, 596, 289, 585 Annotation: Subtype: Link Rect: 45, 586, 85, 575 Checksum: ee7978e5 Type: CRC32 Checksum: 55c93e4ced0b17f5a5f2e3eb699608c1 Type: MD5 Checksum: 1d05efe1565c9c599578b8c15a8b16fde7249970 Type: SHA-1 Checksum: 977069f7f9a46dab3987a4b30ab780b2777f98e3aee0735f372b2eee9a486c78 Type: SHA-256