0a5acd02553dab89a7bbf082a9adfdea 326513.pdf 2fad4e53582537a52d624586725c1cbca5caad4d 326513.pdf 017c3235e066590a1d4c3b96a9b4c6dbcd7f6c5663bd4de55acc683cd57b17b5 326513.pdf Title: Empagliflozin after myocardial infarction with or without diabetes and chronic kidney disease: Insights from EMPACT‐MI Subject: ESC Heart Failure 2025.12:3940-3952 Keywords: 10.1002/ehf2.15393 and CKD; diabetes; heart failure; myocardial infarction; recommendation; SGLT2i Author: Francesco Fioretti, Javed Butler, Jacob A. Udell, W. Schuyler Jones, Mark C. Petrie, Josephine Harrington, Michaela Mattheus, Johann Bauersachs, Antoni Bayes‐Genis, Shaun G. Goodman, Tomasz Gasior, James L. Januzzi, Renato D. Lopes, Piotr Ponikowski, Xavier Rossello, Morten Schou, Peter Meer, Dragos Vinereanu, Shelley Zieroth, Martina Brueckmann, Mikhail Sumin, Deepak L. Bhatt, Adrian F. Hernandez, Stefan D. Anker Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 24.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Sat Dec 13 04:50:39 2025 CET ModDate: Wed Apr 8 10:26:34 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1454164 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AFKJMN+Calibri+20 Type 1C WinAnsi yes yes no 50 0 AFKJLI+Calibri Type 1C WinAnsi yes yes no 51 0 AFKJLJ+Calibri+fb Type 1C Custom yes yes yes 52 0 AFKJMJ+CalibriItalic Type 1C WinAnsi yes yes no 53 0 AFKJMK+CalibriItalic+20 Type 1C WinAnsi yes yes no 54 0 AFKJML+CalibriItalic+01 Type 1C Custom yes yes yes 346 0 AFKJMM+CalibriBold Type 1C WinAnsi yes yes no 55 0 Times-Roman Type 1 WinAnsi no no no 5 0 AFKMPL+TeXCMMathsItalic Type 1C WinAnsi yes yes no 69 0 AFKMPM+TimesNewRomanUnic+22 Type 1C Custom yes yes yes 70 0 AFKNAN+Humanist777BTUnicBoldB Type 1C WinAnsi yes yes no 83 0 AFKNAO+Humanist777BTUnicRomanB Type 1C WinAnsi yes yes no 84 0 AFKNAP+Humanist777BTUnicItalicB Type 1C WinAnsi yes yes no 85 0 AFKNBA+Humanist777BTUnicRomanB+fb Type 1C Custom yes yes yes 86 0 AFKNDA+Humanist777BTUnicRomanB+20 Type 1C WinAnsi yes yes no 91 0 AFLEPB+CalibriBold+fb Type 1C Custom yes yes yes 125 0 AFLFDG+CharterITCUnic+20 Type 1C WinAnsi yes yes no 152 0 AFLFDH+CharterITCUnic+fb Type 1C Custom yes yes yes 153 0 AFLFCF+CharterITCUnicBold Type 1C WinAnsi yes yes no 154 0 AFLFCD+CharterITCUnic Type 1C WinAnsi yes yes no 155 0 AFLFCE+CharterITCUnicItalic Type 1C WinAnsi yes yes no 156 0 AFLFCB+TeXCMMathsSymbols Type 1C Custom yes yes no 157 0 AFLFCC+AdvTTf696b0bf.B Type 1C WinAnsi yes yes no 158 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-04-09 04:01:31 CEST RepresentationInformation: 326513.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-04-08 10:51:08 CEST Size: 1454164 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Empagliflozin after myocardial infarction with or without diabetes and chronic kidney disease: Insights from EMPACT‐MI Destination: maintitle Item: Title: Abstract Destination: section_abs Item: Title: Impact of empagliflozin in patients with and without T2D or CKD in the EMPACT‐MI trial.Baseline characteristics, HF outcomes and subgroup analysis of efficacy endpoints are shown.# Hazard ratios estimated via Cox proportional hazard model (unless indi... Destination: section_abs Item: Title: Introduction Destination: sectionehf215393-sec-0011 Item: Title: Methods Destination: sectionehf215393-sec-0013 Children: Item: Title: Study design and patient population Destination: sectionehf215393-sec-0014 Item: Title: Outcomes Destination: sectionehf215393-sec-0015 Item: Title: Statistical analysis Destination: sectionehf215393-sec-0016 Item: Title: Results Destination: sectionehf215393-sec-0017 Children: Item: Title: Baseline characteristics of the overall population Destination: sectionehf215393-sec-0018 Item: Title: Characteristics and treatment of patients with and without T2D or CKD Destination: sectionehf215393-sec-0019 Item: Title: Event rates in the placebo arm Destination: sectionehf215393-sec-0020 Item: Title: Outcomes Destination: sectionehf215393-sec-0021 Item: Title: Safety Destination: sectionehf215393-sec-0022 Item: Title: Discussion Destination: sectionehf215393-sec-0023 Children: Item: Title: Limitations Destination: sectionehf215393-sec-0024 Item: Title: Conflict of interest statement Destination: sectionehf215393-sec-0025 Item: Title: Acknowledgements Destination: sectionehf215393-sec-8001 Item: Title: Supporting Information Destination: sectionehf215393-sec-0225 Item: Title: References Destination: ref_title Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1420 ImageHeight: 1355 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2016 ImageHeight: 860 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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