5140b3ae8611a8b0944fba3417d6f96c MIO_a2025m11v14p70167.pdf d7056d0fffe32bf5f0ec5b160ca3ce483a033fdd MIO_a2025m11v14p70167.pdf 83238558faa22e3dfa51bbaf2ca9cd70e5ff8d91a11ca54e839b9b0279731f60 MIO_a2025m11v14p70167.pdf Title: Lactic Acid Influences Iron Assimilation by a Fungal Pathogen via the Iron Reductive Uptake Pathway Subject: MicrobiologyOpen 2025.14:e70167 Keywords: Candida albicans; fungal pathogenesis; iron homeostasis; lactate Author: Creator: John Wiley & Sons Producer: iText 4.2.0 by 1T3XT CreationDate: Sat Nov 29 07:48:47 2025 CET ModDate: Fri Mar 27 11:59:01 2026 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1706706 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OOGBNA+AdvOTa9c75b03.BI Type 1C 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application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Lactic Acid Influences Iron Assimilation by a Fungal Pathogen via the Iron Reductive Uptake Pathway Destination: mk:titleTitle1 Children: Item: Title: 1 Introduction Destination: mk:titleH12 Item: Title: 2 Materials and Methods Destination: mk:titleH13 Children: Item: Title: 2.1 Yeast Strains and Growth Conditions Destination: mk:titleH24 Item: Title: 2.2 RNA Extraction, Sequencing, and Analysis Destination: mk:titleH25 Item: Title: 2.3 Quantitative Real-Time Reverse Transcription Polymerase Chain Reaction (qRT-PCR) Destination: mk:titleH26 Item: Title: 2.4 Determination of Iron Concentration Destination: mk:titleH27 Item: Title: 2.5 Growth Analysis Destination: mk:titleH28 Item: Title: 2.6 Statistics and Reproducibility Destination: mk:titleH29 Item: Title: 3 Results and Discussion Destination: mk:titleH110 Children: Item: Title: 3.1 pH-Dependent Transcriptional Regulation of Metal Ion Transport in Response to Lactate Destination: mk:titleH211 Item: Title: 3.2 Interplay Between PKA Signaling and Iron Homeostasis in the Lactate-Induced Transcriptional Response Destination: mk:titleH212 Item: Title: 3.3 Lactate Promotes Intracellular Iron Accumulation in an Ftr1-dependent Manner Destination: mk:titleH213 Item: Title: 4 Conclusion Destination: mk:titleH114 Item: Title: Author Contributions Destination: mk:titleH115 Item: Title: Acknowledgments Destination: mk:titleH116 Item: Title: Ethics Statement Destination: mk:titleH117 Item: Title: Conflicts of Interest Destination: mk:titleH118 Item: Title: Data Availability Statement Destination: mk:titleH119 Item: Title: References Destination: mk:titleH120 Item: Title: Supporting Information Destination: mk:titleH121 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 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