89b4ae9f45102cb87e02e3d2cad25020 41479_2025_Article_181.pdf 6d1bb78e5b97307089a2d0ad668cd063b2c781cf 41479_2025_Article_181.pdf 77b22e145b0b6709cf7c34f72d393aea6bbaa5a12fc7de4bc1a9e014f9cc7d94 41479_2025_Article_181.pdf Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Wed Oct 8 04:52:08 2025 CEST ModDate: Thu Oct 16 09:32:50 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1599879 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Light Type 1C Custom yes no yes 31 0 MyriadPro-Bold Type 1C Custom yes no yes 28 0 MyriadPro-Regular Type 1C Custom yes no yes 27 0 MyriadPro-It Type 1C WinAnsi yes no yes 85 0 MyriadPro-Semibold Type 1C WinAnsi yes no yes 30 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 2630 0 WarnockPro-Regular Type 1C Custom yes no yes 29 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 34 0 MyriadPro-It Type 1C WinAnsi yes no yes 37 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 164 0 MyriadPro-It Type 1C WinAnsi yes no yes 165 0 WarnockPro-It Type 1C WinAnsi yes no yes 66 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 67 0 JYIMOL+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 68 0 MyriadPro-SemiboldIt Type 1C WinAnsi yes no yes 77 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-10 04:12:06 CET RepresentationInformation: 41479_2025_Article_181.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-09 16:11:24 CET Size: 1599879 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2652 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Immunosuppressed patients with COVID-19 pneumonia in ICU: clinical characteristics and factors influencing outcomes Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Study design and participants Item: Title: Study population characteristics Item: Title: Primary and secondary outcomes Item: Title: Subgroup analyses Item: Title: Statistical analysis Item: Title: Results Info: Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Wed Oct 08 04:52:08 CEST 2025 ModDate: Thu Oct 16 09:32:50 CEST 2025 ID: 0x7af71f036e4c8a499a7a6a7efc53337e, 0x0bd578352aa2017387b6f560a7710e0b Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1156 ImageHeight: 1606 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric ImageMask: true Decode: 0, 1 Name: X Fonts: Type1: Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -222, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -175, -250, 1007, 933 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: JYIMOL+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: JYIMOL+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: springer.com springerlink.com springer.com springerlink.com Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 508, 73, 538, 65 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 65, 279, 57 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 750, 204, 740 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 682, 540, 649 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 250, 419, 255, 406 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 137, 383, 142, 370 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 148, 383, 153, 370 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 165, 347, 169, 334 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 174, 347, 179, 334 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 283, 287, 288, 274 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 56, 275, 61, 262 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 59, 227, 64, 214 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 70, 227, 80, 214 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 248, 107, 258, 94 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 149, 71, 159, 58 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 423, 419, 428, 406 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 432, 419, 442, 406 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 428, 347, 437, 334 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 356, 203, 365, 190 Flags: Print AppearanceDictionary: true Destination: 125 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 194, 647, 204, 634 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 59, 611, 69, 598 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 263, 407, 272, 394 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 138, 167, 143, 154 Flags: Print AppearanceDictionary: true Destination: 86 Annotation: Subtype: Link Rect: 453, 563, 463, 550 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 469, 563, 479, 550 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 389, 443, 399, 430 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 459, 251, 469, 238 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 407, 203, 417, 190 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 525, 179, 535, 166 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 409, 143, 419, 130 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 380, 95, 390, 82 Flags: Print AppearanceDictionary: true Destination: 125 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 238, 611, 248, 598 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 407, 647, 412, 634 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 395, 575, 400, 562 Flags: Print AppearanceDictionary: true Destination: 72 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 330, 95, 335, 82 Flags: Print AppearanceDictionary: true Destination: 86 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 216, 107, 221, 94 Flags: Print AppearanceDictionary: true Destination: 93 Annotation: Subtype: Link Rect: 485, 131, 490, 118 Flags: Print AppearanceDictionary: true Destination: 58 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 148, 287, 153, 274 Flags: Print AppearanceDictionary: true Destination: 86 Annotation: Subtype: Link Rect: 172, 239, 177, 226 Flags: Print AppearanceDictionary: true Destination: 93 Annotation: Subtype: Link Rect: 280, 179, 285, 166 Flags: Print AppearanceDictionary: true Destination: 86 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 150, 83, 155, 70 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 160, 83, 170, 70 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 448, 551, 453, 538 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 367, 443, 372, 430 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 498, 383, 507, 370 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 425, 71, 435, 58 Flags: Print AppearanceDictionary: true Destination: 125 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 248, 431, 287, 422 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 422, 149, 413 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Thumb: true Page: Sequence: 12 Thumb: true Checksum: 5da0f27c Type: CRC32 Checksum: 89b4ae9f45102cb87e02e3d2cad25020 Type: MD5 Checksum: 6d1bb78e5b97307089a2d0ad668cd063b2c781cf Type: SHA-1 Checksum: 77b22e145b0b6709cf7c34f72d393aea6bbaa5a12fc7de4bc1a9e014f9cc7d94 Type: SHA-256