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Neurosci. 18:1681079. doi: 10.3389/fnmol.2025.1681079 Keywords: apolipoprotein E; ApoE; aggregates; autophagy; amyloid β; cholesterol; plaques; polyglutamine Author: Priscila Pereira Sena Creator: LaTeX with hyperref package + hypdvips Producer: pikepdf 9.10.2 CreationDate: Thu Oct 23 05:06:08 2025 CEST ModDate: Wed Mar 11 17:26:20 2026 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 1242255 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AHHCOD+MuseoSans-700 Type 1C Custom yes yes yes 1268 0 AHHCPE+MuseoSans-300 Type 1C Custom yes yes yes 1271 0 AHHDDE+MuseoSans-300Italic Type 1C Custom yes yes yes 1274 0 AHHDEE+MinionPro-Regular Type 1C Custom yes yes yes 1277 0 AHHDEF+MuseoSans-500 Type 1C Custom yes yes yes 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exploring common druggable targets across sporadic and monogenic disorders Destination: ariclecounter.1 Children: Item: Title: 1 Introduction Destination: section*.2 Item: Title: 2 Neurodegenerative disorders Destination: section*.3 Children: Item: Title: 2.1 Sporadic neurodegenerative disorders Destination: section*.4 Children: Item: Title: 2.1.1 Alzheimer's disease (AD) Destination: section*.5 Item: Title: 2.1.2 Cerebral amyloid angiopathy (CAA) Destination: section*.6 Item: Title: 2.2 Inherited neurodegenerative disorders Destination: section*.7 Children: Item: Title: 2.2.1 Polyglutamine (polyQ) disorders Destination: section*.8 Item: Title: 2.2.2 Spinocerebellar ataxia type 2 (SCA2) Destination: section*.9 Item: Title: 2.2.3 Spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) Destination: section*.10 Item: Title: 2.2.4 Huntington's disease (HD) Destination: section*.11 Item: Title: 3 Potential points of intervention Destination: section*.12 Item: Title: 4 Conclusion Destination: section*.13 Item: Title: Author contributions Destination: section*.14 Item: Title: Funding Destination: section*.15 Item: Title: Acknowledgments Destination: section*.16 Item: Title: Conflict of interest Destination: section*.17 Item: Title: Generative AI statement Destination: section*.18 Item: Title: Publisher's note Destination: section*.19 Item: Title: References Destination: section*.20 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2123 ImageHeight: 2782 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Interpolate: true Fonts: Type1: Font: BaseFont: AHHDEF+MuseoSans-500 FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: AHHDEF+MuseoSans-500 Flags: Symbolic FontBBox: -121, -210, 1088, 892 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AHHDFG+RMTMIB FontSubset: true FirstChar: 2 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Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders. Front. Mol. Neurosci. 18:1681079. doi: 10.3389/fnmol.2025.1681079 Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders Priscila Pereira Sena Lea Friedrich Alcibiades Villarreal Florian Fath Liubovi Sopco Mar Hern´andez-Guillamon Maria Luiza Saraiva-Pereira Gabrielle Britton Jonasz Jeremiasz Weber Thorsten Schmidt Copyright © 2025 Pereira Sena, Friedrich, Villarreal, Fath, Sopco, Hernandez, Saraiva-Pereira, Britton, Weber and Schmidt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. apolipoprotein E ApoE aggregates autophagy amyloid β cholesterol plaques polyglutamine pikepdf 9.10.2 apolipoprotein E; ApoE; aggregates; autophagy; amyloid β; cholesterol; plaques; polyglutamine uuid:debb089f-2605-4d25-b58d-e786b9c37cfd uuid:380b603e-0a14-4506-b7ae-a19e7db63996 True https://www.frontiersin.org/legal/copyright-statement Copyright © 2025 Pereira Sena, Friedrich, Villarreal, Fath, Sopco, Hernandez, Saraiva-Pereira, Britton, Weber and Schmidt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 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Subtype: Link Rect: 400, 74, 486, 81 Annotation: Subtype: Link Rect: 48, 34, 165, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 449, 800, 546, 807 Annotation: Subtype: Link Rect: 141, 736, 221, 743 Annotation: Subtype: Link Rect: 61, 708, 140, 715 Annotation: Subtype: Link Rect: 190, 679, 241, 687 Annotation: Subtype: Link Rect: 61, 651, 116, 659 Annotation: Subtype: Link Rect: 164, 615, 231, 623 Annotation: Subtype: Link Rect: 151, 588, 207, 595 Annotation: Subtype: Link Rect: 147, 559, 203, 567 Annotation: Subtype: Link Rect: 61, 531, 133, 540 Annotation: Subtype: Link Rect: 61, 505, 152, 512 Annotation: Subtype: Link Rect: 61, 467, 149, 476 Annotation: Subtype: Link Rect: 172, 441, 268, 448 Annotation: Subtype: Link Rect: 155, 405, 235, 412 Annotation: Subtype: Link Rect: 61, 368, 162, 376 Annotation: Subtype: Link Rect: 216, 341, 278, 348 Annotation: Subtype: Link Rect: 120, 313, 200, 320 Annotation: Subtype: Link Rect: 182, 284, 235, 292 Annotation: Subtype: Link Rect: 315, 728, 398, 735 Annotation: Subtype: Link Rect: 389, 698, 463, 707 Annotation: Subtype: Link Rect: 452, 672, 535, 679 Annotation: Subtype: Link Rect: 396, 644, 458, 651 Annotation: Subtype: Link Rect: 315, 615, 389, 623 Annotation: Subtype: Link Rect: 379, 595, 451, 604 Annotation: Subtype: Link Rect: 380, 576, 459, 583 Annotation: Subtype: Link Rect: 453, 548, 535, 555 Annotation: Subtype: Link Rect: 425, 528, 496, 536 Annotation: Subtype: Link Rect: 336, 507, 406, 516 Annotation: Subtype: Link Rect: 315, 471, 370, 480 Annotation: Subtype: Link Rect: 407, 443, 475, 451 Annotation: Subtype: Link Rect: 315, 408, 390, 415 Annotation: Subtype: Link Rect: 390, 378, 443, 387 Annotation: Subtype: Link Rect: 302, 342, 547, 359 Annotation: Subtype: Link Rect: 388, 323, 446, 330 Annotation: Subtype: Link Rect: 302, 284, 547, 303 Annotation: Subtype: Link Rect: 48, 34, 165, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Checksum: fd4bd08c Type: CRC32 Checksum: f0169f8b0be7c3ac053e285cd1a0cfde Type: MD5 Checksum: cb7080d5b51dbb2f7512ec232a09664b5acedc81 Type: SHA-1 Checksum: 519aaad308398dd5b84533b72d6c5c422a6baffe5c0fc8d87c0a83ec00f868ec Type: SHA-256