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Title:           Constitutional epimutations in LTBP4, a component of the TGF-β signaling, and in BRCA1, as potential drivers of early-onset colorectal cancer
Subject:         Clinical Epigenetics, https://doi.org/10.1186/s13148-025-01924-x
Keywords:        Hereditary cancer; Promoter methylation; Constitutional epimutation; Early-onset colorectal cancer; LTBP4; BRCA1
Author:          Mariona Terradas 
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     Item: 
      Title: Constitutional epimutations in LTBP4, a component of the TGF-β signaling, and in BRCA1, as potential drivers of early-onset colorectal cancer
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Patients
         Item: 
          Title: Genome-wide methylation profiling
         Item: 
          Title: Whole-genome sequencing
         Item: 
          Title: Somatic LTBP4 CpG methylation in colorectal cancer and paired normal colon mucosa, and correlation of LTBP4 methylation with LTBP4 expression in tumors
         Item: 
          Title: Methylation-specific PCR-based sequencing
         Item: 
          Title: BRCA1 promoter methylation evaluation by pyrosequencing
         Item: 
          Title: LTBP4 mutational status
         Item: 
          Title: Prediction of HRD from H&E tumor histology slides
         Item: 
          Title: Tumor multi-gene panel analysis
          Children: 
           Item: 
            Title: Mutational signature analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Constitutional genome-wide methylation analysis in genetically unexplained familial  andor early-onset CRC patients
         Item: 
          Title: Constitutional methylation of CpG island 102 in LTBP4 in an early-onset CRC patient
         Item: 
          Title: CpG island 102 somatic methylation correlates with LTBP4 downregulation in colorectal cancers
         Item: 
          Title: Constitutional LTBP4 CpG island 102 methylation and germline LTBP4 variants in unsolved familial andor early-onset colorectal cancer patients
         Item: 
          Title: Low-level constitutional methylation of the BRCA1 promoter in an early-onset CRC patient
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: References
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    Title: Constitutional epimutations in LTBP4, a component of the TGF-β signaling, and in BRCA1, as potential drivers of early-onset colorectal cancer
    Author: Mariona Terradas 
    Subject: Clinical Epigenetics, https://doi.org/10.1186/s13148-025-01924-x
    Keywords: Hereditary cancer; Promoter methylation; Constitutional epimutation; Early-onset colorectal cancer; LTBP4; BRCA1
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   Type: CRC32
  Checksum: 7f326065e78eff5326c336a025fc7d8f
   Type: MD5
  Checksum: c9be16a6312cdcc3e6220a6805d2aea55fdd2d62
   Type: SHA-1
  Checksum: e5aa14990f1f61d85e33711dc601ca3959f3a1fecee063975e855e18ab0c1532
   Type: SHA-256