a5833ae90b9a27f90f0f946a6cb181c2 12325_2025_Article_3208.pdf afe7be03b3ec6dd5860e5bc029c4016ca94efe42 12325_2025_Article_3208.pdf 870556383317e588b46965d2ffb74ee4d5a9b3600657d7222bbef66f3364a65c 12325_2025_Article_3208.pdf Title: Long-Term Transfusion Independence with Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Lower-Risk Myelodysplastic Syndromes in the COMMANDS Trial Subject: Advances in Therapy, https://doi.org/10.1007/s12325-025-03208-5 Keywords: Anemia; Epoetin alfa; Erythroid-stimulating agents; Luspatercept; Myelodysplastic syndromes; Transfusion-independence Author: Guillermo Garcia-Manero Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Mon May 12 17:47:17 2025 CEST ModDate: Fri Jun 20 12:48:43 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 981891 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LUQGHW+STIX-Regular Type 1C WinAnsi yes yes yes 319 0 NXWBRY+STIX-Regular2 Type 1C WinAnsi yes yes yes 288 0 StoneSerifStd-Semibold Type 1C Custom yes no yes 302 0 StoneSerifStd-Medium Type 1C Custom yes no yes 303 0 StoneSansStd-Medium Type 1C WinAnsi yes no yes 306 0 StoneSerifStd-SemiboldIt Type 1C Custom yes no yes 312 0 GDMTOU+StoneSerifStd-MediumItalic Type 1C WinAnsi yes yes yes 317 0 DBRXOE+Wingdings-Regular Type 1C WinAnsi yes yes yes 316 0 NXWBRY+STIX-Regular2 Type 1C WinAnsi yes yes yes 346 0 SGSDCN+Code2000 CID TrueType Identity-H yes yes yes 145 0 StoneSansStd-Bold Type 1C WinAnsi yes no yes 142 0 KRPOZD+GaramondPremrPro-SmbdIt Type 1C Custom yes yes yes 138 0 TSFEQL+GaramondPremrPro-Smbd Type 1C Custom yes yes yes 170 0 PWPWHT+GaramondPremrPro Type 1C Custom yes yes yes 169 0 UXLUVJ+GaramondPremrPro-It Type 1C WinAnsi yes yes yes 173 0 SMEEON+STIXMath-Regular Type 1C Custom yes yes yes 211 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-20 05:00:09 CET RepresentationInformation: 12325_2025_Article_3208.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-19 16:48:49 CET Size: 981891 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 400 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Long-Term Transfusion Independence with Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Lower-Risk Myelodysplastic Syndromes in the COMMANDS Trial Children: Item: Title: Abstract Children: Item: Title: Introduction: Item: Title: Methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Trial Registration Number: Item: Title: Plain Language Summary Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study Design and Participants Item: Title: Outcomes Item: Title: Results Children: Item: Title: Disposition and Baseline Characteristics Item: Title: Red Blood Cell Transfusion Independence Item: Title: Safety and MDS Disease Progression Item: Title: Discussion Item: Title: Conclusion Item: Title: Acknowledgements Item: Title: References Info: Title: Long-Term Transfusion Independence with Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Lower-Risk Myelodysplastic Syndromes in the COMMANDS Trial Author: Guillermo Garcia-Manero Subject: Advances in Therapy, https://doi.org/10.1007/s12325-025-03208-5 Keywords: Anemia; Epoetin alfa; Erythroid-stimulating agents; Luspatercept; Myelodysplastic syndromes; Transfusion-independence Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Mon May 12 18:17:17 CEST 2025 ModDate: Fri Jun 20 13:18:43 CEST 2025 ID: 0xbbd3b02ec8df4044953b512b7a401d4a, 0xdb3e32fc56149e4c89f50dcb491f46b4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1893 ImageHeight: 1089 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1893 ImageHeight: 1043 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 1001 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 2518 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: SGSDCN+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NXWBRY+STIX-Regular2 FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: NXWBRY+STIX-Regular2 Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: PWPWHT+GaramondPremrPro FontSubset: true FirstChar: 29 LastChar: 169 FontDescriptor: FontName: PWPWHT+GaramondPremrPro Flags: Serif, Nonsymbolic FontBBox: -178, -336, 1405, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KRPOZD+GaramondPremrPro-SmbdIt FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: KRPOZD+GaramondPremrPro-SmbdIt Flags: Serif, Nonsymbolic, Italic FontBBox: -247, -418, 1599, 933 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TSFEQL+GaramondPremrPro-Smbd FontSubset: true FirstChar: 31 LastChar: 117 FontDescriptor: FontName: TSFEQL+GaramondPremrPro-Smbd Flags: Serif, Nonsymbolic FontBBox: -183, -329, 1401, 923 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UXLUVJ+GaramondPremrPro-It FontSubset: true FirstChar: 32 LastChar: 110 FontDescriptor: FontName: UXLUVJ+GaramondPremrPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -229, -424, 1659, 945 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: StoneSerifStd-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-Semibold Flags: Serif, Nonsymbolic FontBBox: -190, -251, 1319, 944 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: StoneSansStd-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSansStd-Bold Flags: Nonsymbolic FontBBox: -158, -250, 1540, 946 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: StoneSerifStd-Medium FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-Medium Flags: Serif, Nonsymbolic FontBBox: -201, -250, 1279, 941 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: StoneSansStd-Medium FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSansStd-Medium Flags: Nonsymbolic FontBBox: -179, -250, 1297, 943 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SMEEON+STIXMath-Regular FontSubset: true FirstChar: 31 LastChar: 34 FontDescriptor: FontName: SMEEON+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: StoneSerifStd-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-SemiboldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -209, -256, 1333, 934 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DBRXOE+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: DBRXOE+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: GDMTOU+StoneSerifStd-MediumItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GDMTOU+StoneSerifStd-MediumItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -210, -257, 1299, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: LUQGHW+STIX-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: LUQGHW+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: SGSDCN+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SGSDCN+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true XMP: 2025-05-12T21:17:17+05:30 Springer 2025-06-20T16:18:43+05:30 2025-06-20T16:18:43+05:30 Acrobat Distiller 10.1.8 (Windows) Anemia; Epoetin alfa; Erythroid-stimulating agents; Luspatercept; Myelodysplastic syndromes; Transfusion-independence False application/pdf https://doi.org/10.1007/s12325-025-03208-5 Springer Healthcare Advances in Therapy, https://doi.org/10.1007/s12325-025-03208-5 Anemia Epoetin alfa Erythroid-stimulating agents Luspatercept Myelodysplastic syndromes Transfusion-independence Long-Term Transfusion Independence with Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Lower-Risk Myelodysplastic Syndromes in the COMMANDS Trial Guillermo Garcia-Manero Valeria Santini Amer M. Zeidan Rami S. Komrokji Veronika Pozharskaya Shelonitda Rose Karen Keeperman Yinzhi Lai Sameer Kalsekar Barkha Aggarwal Dimana Miteva David Valcárcel Pierre Fenaux Jake Shortt Matteo Giovanni Della Porta Uwe Platzbecker 10.1007/s12325-025-03208-5 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s12325-025-03208-5 10.1007/s12325-025-03208-5 1865-8652 journal Advances in Therapy The Author(s) 2010-04-23 true 10.1007/s12325-025-03208-5 noindex springer.com springerlink.com VoR uuid:bc444dde-94d8-4892-bc1a-3ae4facf0879 uuid:c810360b-a034-4f9b-9d37-d08745b30d76 default 1 converted uuid:bc444dde-94d8-4892-bc1a-3ae4facf0879 converted to PDF/A-2b pdfToolbox 2025-05-12T21:18:21+05:30 converted uuid:ebc9bc11-32db-4928-990a-8f56c276916c converted to PDF/A-2b pdfToolbox 2025-05-12T21:18:55+05:30 converted uuid:26135dac-3bd8-458d-9d70-f798148f324a converted to PDF/A-2b pdfToolbox 2025-06-20T16:11:41+05:30 2 B Guillermo Garcia-Manero http://orcid.org/0000-0002-3631-2482 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 3576 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 506, 728, 539, 760 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 175, 563, 187, 575 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 69, 252, 245, 263 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3577 Sequence: 2 Thumb: true Page: Label: 3578 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 279, 92, 285, 104 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 524, 641, 530, 653 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 317, 554, 323, 565 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 329, 554, 334, 565 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 318, 529, 323, 540 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 328, 529, 340, 540 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 425, 479, 437, 490 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 442, 479, 454, 490 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 372, 354, 383, 365 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 441, 103, 452, 115 Flags: Print AppearanceDictionary: true Destination: 112 Thumb: true Page: Label: 3579 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 153, 629, 164, 641 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 116, 450, 128, 462 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 135, 450, 146, 462 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 399, 566, 411, 578 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 472, 125, 484, 137 Flags: Print AppearanceDictionary: true Destination: 119 Thumb: true Page: Label: 3580 Sequence: 5 Thumb: true Page: Label: 3581 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 181, 641, 192, 653 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 198, 641, 209, 653 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 189, 512, 195, 524 Flags: Print AppearanceDictionary: true Destination: 36 Annotation: Subtype: Link Rect: 513, 704, 519, 716 Flags: Print AppearanceDictionary: true Destination: 41 Annotation: Subtype: Link Rect: 455, 479, 467, 491 Flags: Print AppearanceDictionary: true Destination: 112 Thumb: true Page: Label: 3582 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 131, 704, 137, 716 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 141, 479, 152, 491 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 479, 639, 485, 651 Flags: Print AppearanceDictionary: true Destination: 68 Annotation: Subtype: Link Rect: 518, 589, 530, 601 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 451, 514, 457, 526 Flags: Print AppearanceDictionary: true Destination: 68 Thumb: true Page: Label: 3583 Sequence: 8 Thumb: true Page: Label: 3584 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 256, 479, 262, 491 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 391, 616, 397, 628 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 402, 616, 414, 628 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 456, 479, 467, 491 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 463, 441, 475, 453 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 318, 379, 330, 391 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 384, 341, 396, 353 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 468, 291, 480, 303 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 318, 241, 330, 253 Flags: Print AppearanceDictionary: true Destination: 112 Thumb: true Page: Label: 3585 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 134, 341, 146, 353 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 114, 304, 126, 316 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 134, 304, 146, 316 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 261, 229, 274, 241 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 432, 129, 444, 141 Flags: Print AppearanceDictionary: true Destination: 119 Thumb: true Page: Label: 3586 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 91, 629, 104, 641 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 109, 629, 122, 641 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 129, 629, 141, 641 Flags: Print AppearanceDictionary: true Destination: 119 Annotation: Subtype: Link Rect: 197, 554, 209, 566 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 214, 554, 226, 566 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 326, 124, 537, 136 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 314, 112, 537, 124 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 314, 99, 369, 111 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3587 Sequence: 12 Thumb: true Page: Label: 3588 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 200, 529, 291, 541 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 69, 516, 206, 528 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3589 Sequence: 14 Thumb: true Checksum: 807eb3e3 Type: CRC32 Checksum: a5833ae90b9a27f90f0f946a6cb181c2 Type: MD5 Checksum: afe7be03b3ec6dd5860e5bc029c4016ca94efe42 Type: SHA-1 Checksum: 870556383317e588b46965d2ffb74ee4d5a9b3600657d7222bbef66f3364a65c Type: SHA-256