a9e984af6777bd89fff09d146a7ebc20  327118.pdf
b6384bdc656a31a277b1207df45bee39eadb8862  327118.pdf
18c2270c29329b13e243ed1b7f4767a26ed781ec5bc187af1b69e4ec96288394  327118.pdf

Title:           Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement
Subject:         npj Genomic Medicine, doi:10.1038/s41525-025-00535-y
Keywords:        
Author:          Laura Batlle-Masó
Creator:         Springer
Producer:        iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Mon Nov  3 15:34:05 2025 CET
ModDate:         Fri Nov 28 16:41:04 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           8
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1321856 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EOAJEG+GraphikNaturel-Regular        Type 1C           WinAnsi          yes yes no     358  0
EOAKEJ+AdvOTf0129623+20              Type 1C           WinAnsi          yes yes no      73  0
EOAKEK+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no      55  0
EOAKEL+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes     56  0
EOAKEM+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no      57  0
EOAKEN+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes     58  0
EOAKEO+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no      59  0
EOAJFH+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     359  0
EOAJFI+AdvOT34fe1490.B               Type 1C           WinAnsi          yes yes no      63  0
EOAJFJ+AdvOTf0129623                 Type 1C           WinAnsi          yes yes no      64  0
EOAJLI+AdvOTf94803d4                 Type 1C           WinAnsi          yes yes no      65  0
EOAJLJ+AdvOTfbba3ace.B               Type 1C           WinAnsi          yes yes no     360  0
EOAJLK+AdvOTfbba3ace.B+fb            Type 1C           Custom           yes yes yes    361  0
EOAKDI+AdvOT3a037357.I               Type 1C           WinAnsi          yes yes no     154  0
EOAKEI+AdvOTf0129623+fb              Type 1C           Custom           yes yes yes    155  0
EOAKNM+AdvTT691e30a0                 Type 1C           WinAnsi          yes yes no      60  0
EOAKNN+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      61  0
EOAOOF+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no      62  0
EOAPKC+AdvOT34fe1490.B+20            Type 1C           WinAnsi          yes yes no      74  0
EOAPKD+AdvOTf0129623+03              Type 1C           Custom           yes yes yes     75  0
EOBNMN+AdvOTb65e897d.B+fb            Type 1C           Custom           yes yes yes    104  0
EOBNON+AdvOT1ef757c0+21              Type 1C           WinAnsi          yes yes no     119  0
EOCDOJ+AdvOTb65e897d.B+20            Type 1C           WinAnsi          yes yes no     120  0
EOCDPK+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     152  0
EOCEAK+AdvOT46dcae81+03              Type 1C           Custom           yes yes yes    153  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-03-24 04:09:16 CET
 RepresentationInformation: 327118.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-03-23 12:05:40 CET
  Size: 1321856
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff5' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff2' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff8' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff3' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff12' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff10' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff6' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff4' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff9' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff11' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff7' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff9' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff4' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff12' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff6' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff3' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff8' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff1' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff10' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff5' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff2' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff7' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff11' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found
   ID: PDF-HUL-122
   Offset: 964817
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 447
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Patients
          Destination: B1
         Item: 
          Title: Sanger sequencing
          Destination: B2
         Item: 
          Title: Whole exome sequencing (WES)
          Destination: B3
         Item: 
          Title: NGS-based deep amplicon sequencing (NGS-DAS)
          Destination: B4
         Item: 
          Title: Single cell RNA sequencing (scRNAseq): sample preparation and sequencing
          Destination: B5
         Item: 
          Title: Single cell RNA sequencing (scRNAseq): data analysis
          Destination: B6
       Item: 
        Title: Data availability
        Destination: A4
       Item: 
        Title: Code availability
        Destination: A5
       Item: 
        Title: References
        Destination: A6
       Item: 
        Title: Acknowledgements
        Destination: A7
       Item: 
        Title: Author contributions
        Destination: A8
       Item: 
        Title: Competing interests
        Destination: A9
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement
    Author: Laura Batlle-Masó
    Subject: npj Genomic Medicine, doi:10.1038/s41525-025-00535-y
    Keywords: 
    Creator: Springer
    Producer: iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Mon Nov 03 16:04:05 CET 2025
    ModDate: Fri Nov 28 16:41:04 CET 2025
   ID: 0xc01a57218c5567346d92b56a8042dbc2, 0xde7a4cd1e75dc67506f4e9b2920f98f4
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 739
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1750
      ImageHeight: 2487
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 735
      ImageHeight: 2500
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EOAJFJ+AdvOTf0129623
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: EOAJFJ+AdvOTf0129623
       Flags: Nonsymbolic
       FontBBox: -52, -208, 906, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAJLI+AdvOTf94803d4
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: EOAJLI+AdvOTf94803d4
       Flags: Nonsymbolic
       FontBBox: -41, -218, 937, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKEJ+AdvOTf0129623+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: EOAKEJ+AdvOTf0129623+20
       Flags: Nonsymbolic
       FontBBox: -156, -145, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAPKC+AdvOT34fe1490.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EOAPKC+AdvOT34fe1490.B+20
       Flags: Nonsymbolic
       FontBBox: -156, -166, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAPKD+AdvOTf0129623+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EOAPKD+AdvOTf0129623+03
       Flags: Symbolic
       FontBBox: 0, -197, 666, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOCDPK+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: EOCDPK+AdvOTa20b42a7
       Flags: Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOCEAK+AdvOT46dcae81+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EOCEAK+AdvOT46dcae81+03
       Flags: Symbolic
       FontBBox: -31, -208, 739, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOAKDI+AdvOT3a037357.I
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: EOAKDI+AdvOT3a037357.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKEI+AdvOTf0129623+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EOAKEI+AdvOTf0129623+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOAJEG+GraphikNaturel-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 124
      FontDescriptor: 
       FontName: EOAJEG+GraphikNaturel-Regular
       Flags: Nonsymbolic
       FontBBox: -230, -252, 1092, 1113
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAJFH+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 99
      LastChar: 111
      FontDescriptor: 
       FontName: EOAJFH+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAJLJ+AdvOTfbba3ace.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: EOAJLJ+AdvOTfbba3ace.B
       Flags: Nonsymbolic
       FontBBox: -31, -229, 968, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOBNMN+AdvOTb65e897d.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EOBNMN+AdvOTb65e897d.B+fb
       Flags: Symbolic
       FontBBox: 0, -10, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOAJLK+AdvOTfbba3ace.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EOAJLK+AdvOTfbba3ace.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 583, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOAKEK+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 239
      FontDescriptor: 
       FontName: EOAKEK+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOBNON+AdvOT1ef757c0+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: EOBNON+AdvOT1ef757c0+21
       Flags: Nonsymbolic
       FontBBox: 0, -20, 822, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKEL+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EOAKEL+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOCDOJ+AdvOTb65e897d.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EOCDOJ+AdvOTb65e897d.B+20
       Flags: Nonsymbolic
       FontBBox: -125, -177, 1052, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKEM+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 44
      LastChar: 103
      FontDescriptor: 
       FontName: EOAKEM+AdvOT7d6df7ab.I
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKEN+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EOAKEN+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EOAKEO+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: EOAKEO+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKNM+AdvTT691e30a0
      FontSubset: true
      FirstChar: 42
      LastChar: 42
      FontDescriptor: 
       FontName: EOAKNM+AdvTT691e30a0
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1020, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAKNN+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 43
      FontDescriptor: 
       FontName: EOAKNN+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAOOF+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 45
      LastChar: 124
      FontDescriptor: 
       FontName: EOAOOF+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EOAJFI+AdvOT34fe1490.B
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: EOAJFI+AdvOT34fe1490.B
       Flags: Nonsymbolic
       FontBBox: -52, -208, 937, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
      dc:format="application/pdf"
      dc:identifier="doi:10.1038/s41525-025-00535-y"
      prism:doi="10.1038/s41525-025-00535-y"
      prism:url="http://dx.doi.org/10.1038/s41525-025-00535-y"
      prism:aggregationType="journal"
      prism:publicationName="npj Genomic Medicine"
      prism:copyright="© 2025, The Author(s)"
      prism:issn="2056-7944"
      pdfx:doi="10.1038/s41525-025-00535-y"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="True"
      crossmark:DOI="10.1038/s41525-025-00535-y"
      xmp:CreatorTool="Springer"
      xmp:ModifyDate="2025-11-28T16:41:04+01:00"
      xmp:CreateDate="2025-11-03T20:04:05+05:30"
      xmp:MetadataDate="2025-11-28T16:41:04+01:00"
      xmpRights:Marked="True"
      pdf:Keywords=""
      pdf:Producer="iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      jav:journal_article_version="VoR"
      xmpMM:DocumentID="uuid:9a77494c-831b-47e5-bb44-d664a21c23a7"
      xmpMM:InstanceID="uuid:f7f1d147-2098-4380-af1b-aba6c76a0e83"
      xmpMM:RenditionClass="default"
      xmpMM:VersionID="1"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li>Laura Batlle-Masó</rdf:li>
          <rdf:li>Joan Padrosa Pulido</rdf:li>
          <rdf:li>Anna Esteve-Codina</rdf:li>
          <rdf:li>Janire Perurena-Prieto</rdf:li>
          <rdf:li>Clara Franco-Jarava</rdf:li>
          <rdf:li>Aina Aguiló-Cucurull</rdf:li>
          <rdf:li>Mónica Martínez-Gallo</rdf:li>
          <rdf:li>Cristina Cea</rdf:li>
          <rdf:li>Marta Rodriguez-Aliberas</rdf:li>
          <rdf:li>Pere Soler-Palacín</rdf:li>
          <rdf:li>Ferran Casals</rdf:li>
          <rdf:li>Sara Redondo Velao</rdf:li>
          <rdf:li>Montserrat Torrent</rdf:li>
          <rdf:li>Laia Alsina</rdf:li>
          <rdf:li>Roger Colobran</rdf:li>
        </rdf:Seq>
      </dc:creator>
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Springer US</rdf:li>
        </rdf:Bag>
      </dc:publisher>
      <dc:subject>
        <rdf:Bag/>
      </dc:subject>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">npj Genomic Medicine, doi:10.1038/s41525-025-00535-y</rdf:li>
        </rdf:Alt>
      </dc:description>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:bee8d168-1700-45d5-9bce-4b23d33f6b91"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-11-03T20:05:23+05:30"/>
        </rdf:Seq>
      </xmpMM:History>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A structure containing the characteristics of a font used in a document"
                  pdfaProperty:name="Fonts"
                  pdfaProperty:valueType="Bag Font"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="A structure containing the characteristics of a font used in a document."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Font#"
                  pdfaType:prefix="stFnt"
                  pdfaType:type="Font"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright "
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;"
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;"
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 471, 563, 479, 595
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 555, 120, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 122, 555, 125, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 217, 555, 220, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 222, 555, 225, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 317, 555, 320, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 321, 555, 324, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 425, 555, 428, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 430, 555, 433, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 434, 555, 437, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 439, 555, 442, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 126, 542, 129, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 542, 224, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 542, 229, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 230, 542, 233, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 335, 542, 338, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 339, 542, 342, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 343, 542, 346, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 348, 542, 351, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 408, 542, 411, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 149, 530, 155, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 239, 530, 242, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 243, 530, 249, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 251, 530, 257, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 320, 530, 326, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 328, 530, 334, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 335, 530, 341, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 343, 530, 349, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 530, 446, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 120, 517, 126, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 177, 517, 183, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 184, 517, 190, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 192, 517, 198, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 276, 517, 279, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 281, 517, 284, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 285, 517, 288, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 289, 517, 292, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 294, 517, 297, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 132, 105, 135, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 240, 95, 242, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 505, 255, 507, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 510, 255, 512, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 467, 212, 469, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 470, 212, 473, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 256, 48, 357, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 231, 593, 235, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 273, 593, 277, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 211, 518, 215, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 282, 502, 285, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 237, 470, 239, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 242, 470, 244, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 57, 401, 61, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 281, 405, 283, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 39, 294, 43, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 237, 283, 242, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 461, 716, 463, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 306, 626, 310, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 367, 598, 370, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 427, 561, 431, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 536, 551, 541, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 356, 497, 361, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 547, 433, 551, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 504, 379, 508, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 469, 336, 473, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 476, 315, 480, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 502, 315, 506, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 324, 79, 328, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 58, 240, 63, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 56, 219, 60, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 237, 197, 241, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 154, 116, 157, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 158, 116, 161, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 405, 234, 410, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 541, 234, 546, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 349, 202, 353, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 195, 658, 289, 667
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 636, 178, 645
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 269, 636, 294, 645
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 626, 146, 635
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 604, 294, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 593, 184, 602
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 85, 234, 90, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 59, 191, 64, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 230, 180, 235, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 110, 105, 115, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 508, 630, 513, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 306, 551, 412, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 347, 560, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 337, 342, 345
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 98, 264, 105
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 120, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: e5ccbc25
   Type: CRC32
  Checksum: a9e984af6777bd89fff09d146a7ebc20
   Type: MD5
  Checksum: b6384bdc656a31a277b1207df45bee39eadb8862
   Type: SHA-1
  Checksum: 18c2270c29329b13e243ed1b7f4767a26ed781ec5bc187af1b69e4ec96288394
   Type: SHA-256