f46390a46fefbdba4865dc225b14acaa s41380-025-02910-8_1.pdf bbb75c918be4d1164a1051bbb0cdfc0a45a3cedf s41380-025-02910-8_1.pdf 55f5007bbc38ef73ec1f2c93a188593e9614d38eb2917dae8c8d55cdf3298c05 s41380-025-02910-8_1.pdf Title: Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models Subject: Molecular Psychiatry, doi:10.1038/s41380-025-02910-8 Keywords: Author: Raül Andero Creator: Springer CreationDate: Thu Apr 17 06:43:01 2025 CEST ModDate: Thu Apr 17 06:44:36 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1357581 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JPBIEF+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 407 0 JPBIML+AdvOT46dcae81+fb Type 1C Custom yes yes yes 421 0 JPBIMM+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 422 0 JPBIMN+AdvOT65f8a23b.I+fb Type 1C Custom yes yes yes 423 0 JPBINO+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 437 0 Arial-BoldMT Type 1C WinAnsi yes no no 408 0 JPBIKF+AdvOT46dcae81 Type 1C WinAnsi yes yes no 415 0 JPBIKG+AdvTT6780a46b Type 1C WinAnsi yes yes no 416 0 JPBILG+AdvTT2876772e+27 Type 1C Custom yes yes yes 417 0 JPBIMH+AdvMyriad_I Type 1C WinAnsi yes yes no 424 0 JPBIMI+AdvMyriad_R Type 1C WinAnsi yes yes no 425 0 JPBIMJ+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 426 0 JPBIMK+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 427 0 JPCIHP+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 209 0 JPCILO+AdvOT919a0533.B Type 1C WinAnsi yes yes no 223 0 JPCILP+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 219 0 JPCIMA+AdvTTab7e17fd Type 1C WinAnsi yes yes no 216 0 JPCIMB+AdvTTab7e17fd+22 Type 1C Custom yes yes no 212 0 JPCJAB+AdvOT46dcae81+03 Type 1C Custom yes yes yes 226 0 JPCPJJ+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 231 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-19 04:08:06 CET RepresentationInformation: s41380-025-02910-8_1.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-18 18:18:17 CET Size: 1357581 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 748 FreeObjects: 89 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models Destination: title_link Children: Item: Title: Introduction Destination: A1 Children: Item: Title: Sex differences in stress interacting with fear memories Destination: B1 Item: Title: Hormones influencing stress and fear memory mechanisms Destination: B2 Item: Title: Genetics and epigenetics in stress and pathological fear memory mechanisms Destination: B3 Children: Item: Title: FKBP5 Destination: C1 Item: Title: The PACAP-PAC1R system Destination: C2 Item: Title: Endocannabinoid system Destination: C3 Item: Title: TrkB-BDNF system Destination: C4 Item: Title: Limitations Destination: A2 Item: Title: Conclusions Destination: A3 Item: Title: Acknowledgements Destination: A4 Item: Title: Author contributions Destination: A5 Item: Title: Competing interests Destination: A6 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models Author: Raül Andero Subject: Molecular Psychiatry, doi:10.1038/s41380-025-02910-8 Keywords: Creator: Springer CreationDate: Thu Apr 17 07:13:01 CEST 2025 ModDate: Thu Apr 17 07:14:36 CEST 2025 ID: 0x91d2eae685107c5ed8c242804a03332a, 0xe4e7918d7c8f0149963d60d1141a5751 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1930 ImageHeight: 2500 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1750 ImageHeight: 936 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: JPBIKG+AdvTT6780a46b FontSubset: true FirstChar: 40 LastChar: 252 FontDescriptor: FontName: JPBIKG+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBILG+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JPBILG+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPCJAB+AdvOT46dcae81+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JPCJAB+AdvOT46dcae81+03 Flags: Symbolic FontBBox: -31, -208, 739, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPBIML+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JPBIML+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPBIMM+AdvOT65f8a23b.I FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: JPBIMM+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIMN+AdvOT65f8a23b.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JPBIMN+AdvOT65f8a23b.I+fb Flags: Symbolic FontBBox: 0, 0, 781, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPCPJJ+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: JPCPJJ+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIMH+AdvMyriad_I FontSubset: true FirstChar: 77 LastChar: 121 FontDescriptor: FontName: JPBIMH+AdvMyriad_I Flags: Nonsymbolic FontBBox: -104, -239, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIMI+AdvMyriad_R FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: JPBIMI+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIMJ+AdvOT3b30f6db.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: JPBIMJ+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIMK+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JPBIMK+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCIHP+AdvOT7d2ebc01 FontSubset: true FirstChar: 48 LastChar: 55 FontDescriptor: FontName: JPCIHP+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCIMB+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: JPCIMB+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JPBINO+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 121 FontDescriptor: FontName: JPBINO+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPBIEF+AdvTT5afe5d37.B FontSubset: true FirstChar: 69 LastChar: 88 FontDescriptor: FontName: JPBIEF+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCIMA+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: JPCIMA+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCILP+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JPCILP+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPBIKF+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: JPBIKF+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCILO+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 105 FontDescriptor: FontName: JPCILO+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41380-025-02910-8 Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models Raül Andero Springer US Molecular Psychiatry, doi:10.1038/s41380-025-02910-8 10.1038/s41380-025-02910-8 http://dx.doi.org/10.1038/s41380-025-02910-8 journal Molecular Psychiatry © 2025, The Author(s), under exclusive licence to Springer Nature Limited 1476-5578 10.1038/s41380-025-02910-8 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-025-02910-8 springer.com springerlink.com Springer 2025-04-17T10:14:36+05:30 2025-04-17T10:13:01+05:30 2025-04-17T10:14:36+05:30 True VoR uuid:5be3ba02-a318-4797-9f65-168c7aa469c6 uuid:ad75d686-8418-4d4f-a684-6617459a6167 default 1 converted uuid:449cedd7-dd6c-497c-a64c-94d8c0ab7eca converted to PDF/A-2b pdfToolbox 2025-04-17T10:14:35+05:30 2 B Raül Andero http://orcid.org/0000-0003-3641-8903 http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the ORCID of an author. orcid URI Gives the name of an author. name Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 2219 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 84, 604, 85, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 84, 604, 85, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 93, 604, 96, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 604, 93, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 93, 604, 94, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 209, 406, 375, 415 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 100, 320, 104, 329 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 77, 261, 81, 269 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 251, 221, 256, 230 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 120, 171, 125, 180 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 275, 161, 279, 170 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 451, 280, 456, 289 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 518, 251, 522, 259 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 470, 221, 474, 230 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 415, 151, 419, 160 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 60, 80, 119, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2220 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 168, 63, 177, 72 Flags: Print AppearanceDictionary: true Destination: 166 Thumb: true Page: Label: 2221 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 128, 549, 137, 558 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 233, 519, 242, 528 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 228, 480, 238, 488 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 144, 440, 153, 449 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 83, 250, 92, 259 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 249, 240, 258, 249 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 268, 220, 273, 229 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Rect: 188, 191, 197, 200 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 154, 151, 163, 160 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 73, 121, 82, 130 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 170, 101, 179, 110 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 174, 61, 184, 70 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 427, 529, 436, 538 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 533, 499, 542, 508 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 515, 480, 524, 488 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 371, 400, 380, 409 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 516, 400, 525, 409 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 474, 370, 483, 379 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 487, 370, 497, 379 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 439, 330, 448, 339 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 454, 330, 463, 339 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 433, 290, 442, 299 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 347, 211, 357, 220 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 361, 211, 370, 220 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 495, 191, 504, 200 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 509, 191, 518, 200 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 322, 161, 332, 170 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 317, 101, 322, 110 Flags: Print AppearanceDictionary: true Destination: 49 Annotation: Subtype: Link Rect: 492, 81, 501, 90 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 507, 81, 516, 90 Flags: Print AppearanceDictionary: true Destination: 181 Thumb: true Page: Label: 2222 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 185, 391, 194, 400 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 110, 331, 119, 340 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 153, 331, 162, 340 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 63, 311, 72, 320 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 47, 301, 56, 310 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 180, 271, 189, 280 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 194, 271, 203, 280 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 141, 261, 150, 270 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 243, 241, 253, 250 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 215, 191, 224, 200 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 47, 151, 56, 161 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 186, 142, 195, 151 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 231, 122, 241, 131 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 258, 102, 267, 111 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 68, 62, 77, 71 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 480, 411, 489, 420 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 494, 411, 503, 420 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 507, 411, 517, 420 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 333, 381, 342, 390 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 349, 381, 358, 390 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 346, 351, 356, 360 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 360, 351, 369, 360 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 436, 221, 445, 230 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 455, 171, 464, 180 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 343, 122, 352, 131 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 497, 92, 506, 101 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 313, 62, 322, 71 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 328, 62, 337, 71 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 546, 482, 555, 491 Flags: Print AppearanceDictionary: true Destination: 181 Thumb: true Page: Label: 2223 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 142, 713, 151, 722 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 247, 703, 256, 712 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 209, 673, 219, 682 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 160, 613, 169, 622 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 165, 593, 174, 602 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 89, 514, 98, 523 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 60, 484, 69, 493 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 194, 444, 203, 453 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 183, 414, 192, 423 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 197, 414, 206, 423 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 72, 384, 81, 393 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 87, 384, 96, 393 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 270, 334, 279, 343 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 261, 314, 270, 323 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 178, 284, 187, 293 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 137, 245, 146, 254 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 185, 235, 194, 244 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 270, 215, 279, 224 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 161, 145, 171, 154 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 177, 145, 186, 154 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 61, 115, 71, 124 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 362, 653, 371, 662 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 509, 633, 518, 642 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 512, 434, 521, 443 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 434, 414, 443, 423 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 411, 374, 420, 383 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 425, 374, 434, 383 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 537, 354, 545, 363 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 509, 324, 518, 333 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 304, 265, 313, 274 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 407, 205, 416, 214 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 338, 75, 348, 84 Flags: Print AppearanceDictionary: true Destination: 181 Thumb: true Page: Label: 2224 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 150, 723, 159, 732 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 165, 723, 174, 732 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 279, 703, 289, 712 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 92, 673, 101, 682 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 186, 643, 195, 652 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 218, 573, 227, 582 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 47, 414, 56, 423 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 150, 404, 159, 413 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 69, 384, 78, 393 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 83, 384, 92, 393 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 89, 354, 98, 363 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 103, 354, 112, 363 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 208, 334, 217, 343 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 109, 275, 118, 284 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 47, 225, 56, 234 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 61, 225, 70, 234 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 269, 205, 278, 214 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 246, 175, 255, 184 Flags: Print AppearanceDictionary: true Destination: 181 Annotation: Subtype: Link Rect: 261, 175, 270, 184 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 146, 75, 155, 84 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 346, 703, 356, 712 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 368, 623, 377, 632 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 381, 593, 390, 602 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 348, 494, 358, 503 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 475, 434, 485, 443 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 382, 275, 391, 284 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 484, 245, 493, 254 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 313, 215, 322, 224 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 479, 215, 488, 224 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 455, 185, 464, 194 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 468, 185, 482, 194 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 451, 155, 460, 164 Flags: Print AppearanceDictionary: true Destination: 166 Annotation: Subtype: Link Rect: 426, 115, 440, 124 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 382, 75, 395, 84 Flags: Print AppearanceDictionary: true Destination: 188 Thumb: true Page: Label: 2225 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 102, 723, 115, 732 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 217, 683, 230, 692 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 157, 653, 170, 662 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 243, 464, 256, 473 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 86, 225, 99, 234 Flags: Print AppearanceDictionary: true Destination: 188 Annotation: Subtype: Link Rect: 317, 688, 530, 694 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 480, 616, 549, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 607, 405, 614 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2226 Sequence: 8 Thumb: true Page: Label: 2227 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 51, 490, 253, 497 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 661, 512, 668 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 353, 549, 360 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 344, 324, 351 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 173, 549, 180 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 164, 431, 171 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 34ddee73 Type: CRC32 Checksum: f46390a46fefbdba4865dc225b14acaa Type: MD5 Checksum: bbb75c918be4d1164a1051bbb0cdfc0a45a3cedf Type: SHA-1 Checksum: 55f5007bbc38ef73ec1f2c93a188593e9614d38eb2917dae8c8d55cdf3298c05 Type: SHA-256