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Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Study design, setting and patients Destination: slink1 Item: Title: Interventions Destination: slink2 Item: Title: Endpoints Destination: slink3 Item: Title: Statistical analysis Destination: slink4 Item: Title: Ethics and registration Destination: slink5 Item: Title: Role of the funding source Destination: slink6 Item: Title: Results Destination: flink3 Children: Item: Title: Patients Destination: slink7 Item: Title: Exposure Destination: slink8 Item: Title: Intubation or death Destination: slink9 Item: Title: Other endpoints Destination: slink10 Item: Title: Discussion Destination: flink4 Item: Title: ContributorsFvH, CP, AA, BD and JL designed the meta-trial project. AV, RA, TI, RM, MB, GDN, CS, TW, DS, AW, JS, DC, BM, CC ... Destination: blink1 Item: Title: Data sharing statementThe research protocols for the meta-trial and each individual trial are available in the appendix. De ... Destination: blink2 Item: Title: Declaration of interests Destination: blink3 Item: Title: Acknowledgements Destination: blink4 Item: Title: Appendix A. Supplementary data Destination: flink5 Item: Title: References Destination: blink5 Info: Title: Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies Author: Frank M.P. van Haren Subject: eClinicalMedicine, 88 (2025) 103339. doi:10.1016/j.eclinm.2025.103339 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Sat Oct 18 06:51:48 CEST 2025 ModDate: Sat Oct 18 06:56:10 CEST 2025 ID: 0x37e252e441a089aa5a7e3c26d722c1e7, 0x565642bc8fd8094ba9c42e42fb1ab69c Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: MYEMFP+ScalaLF-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Font: BaseFont: JLCPVG+ScalaLF-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: HKELJD+Shaker-RBI Encoding: Identity-H ToUnicode: true Font: BaseFont: YDBIFI+ScalaLF-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: HQPBKA+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: HQPBKA+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: BIPDFF+Shaker2Lancet-Regular FontSubset: true FirstChar: 1 LastChar: 82 FontDescriptor: FontName: BIPDFF+Shaker2Lancet-Regular Flags: Nonsymbolic FontBBox: -158, -241, 1019, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RBTLGX+Shaker2Lancet-Bold FontSubset: true FirstChar: 1 LastChar: 61 FontDescriptor: FontName: RBTLGX+Shaker2Lancet-Bold Flags: Nonsymbolic, ForceBold FontBBox: -164, -241, 1109, 981 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YTTUIC+Shaker2Lancet-Italic FontSubset: true FirstChar: 1 LastChar: 49 FontDescriptor: FontName: YTTUIC+Shaker2Lancet-Italic Flags: Nonsymbolic, Italic FontBBox: -177, -241, 960, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: MYEMFP+ScalaLF-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MYEMFP+ScalaLF-Regular Flags: Nonsymbolic FontBBox: -64, -256, 1200, 870 FontFile2: true Font: BaseFont: YDBIFI+ScalaLF-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YDBIFI+ScalaLF-Italic Flags: Nonsymbolic FontBBox: -174, -256, 1200, 843 FontFile2: true Font: BaseFont: HKELJD+Shaker-RBI CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HKELJD+Shaker-RBI Flags: Nonsymbolic, Italic FontBBox: -120, -245, 953, 837 FontFile2: true Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true Font: BaseFont: JLCPVG+ScalaLF-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JLCPVG+ScalaLF-Bold Flags: Nonsymbolic, ForceBold FontBBox: -62, -256, 1199, 892 FontFile2: true XMP: application/pdf doi:10.1016/j.eclinm.2025.103339 Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies Frank M.P. van Haren Sarah J. Valle Ary Serpa Neto Marcus J. Schultz John G. Laffey Antonio Artigas Barry Dixon Alicia B. Vilaseca Ruben A. Barbera Tarek I. Ismail Rabab S. Mahrous Mohamed Badr Gilberto DeNucci Carlos Sverdloff Marta Camprubi-Rimblas David W. Cosgrave Bairbre McNicholas Catriona Cody Gerard Curley Thomas L. Smoot Sabrina Staas Khine Sann Caitlin Sas Anusha Belani Christopher Hillman Sidharta Kusuma Manggala Dita Aditianingsih Adhrie Sugiarto Mira Yulianti Herikurniawan Herikurniawan Robert Sinto Aino Nindya Auerkari Septian Adi Permana Ashley Woodcock Mary Carroll Tom Wilkinson Dave Singh Janis Kay Shute Miles Carroll Clive Page COVID-19 ARDS Inhaled heparin Nebulised heparin Unfractionated heparin SARS-CoV-2 Respiratory failure Pandemic Randomised trial Meta-trial Intubation Mortality eClinicalMedicine, 88 (2025) 103339. doi:10.1016/j.eclinm.2025.103339 The Author(s) journal eClinicalMedicine © 2025 The Author(s). Published by Elsevier Ltd. 2589-5370 88 October 2025 103339 103339 10.1016/j.eclinm.2025.103339 https://doi.org/10.1016/j.eclinm.2025.103339 2010-04-23 true 10.1016/j.eclinm.2025.103339 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.eclinm.2025.103339 noindex 2010-04-23 true PStill version 1.84.42 sciencedirect.com elsevier.com Elsevier 2025-10-18T09:51:48+05:30 2025-10-18T09:56:10+05:30 2025-10-18T09:56:10+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json PDFlib+PDI 10.0.2p2 (C++/Win64) uuid:4efb86ed-6818-450a-91b6-f78231da6174 uuid:cf0aa7e2-ad5e-438f-94fb-faf118049844 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 39, 664, 39, 664 Flags: Print Annotation: Subtype: Link Contents: Rect: 107, 566, 107, 568 Flags: Print Annotation: Subtype: Link Contents: Rect: 109, 567, 112, 573 Flags: Print Destination: 2637 Annotation: Subtype: Link Contents: Rect: 113, 567, 116, 575 Flags: Print Destination: 2637 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