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Title:           Analysis of pfhrp2 and pfhrp3 gene deletions, and the structure and variability of PfHRP2 and PfHRP3 proteins: implications for the performance of malaria rapid diagnostic tests in Cubal, Angola
Subject:         Malaria Journal, https://doi.org/10.1186/s12936-025-05523-2
Keywords:        Malaria diagnosis; Angola; pfhrp2; pfhrp3; Rapid diagnostic test; Deletion; Antigenic variability; Amino acid repeats; Epitopes
Author:          Alejandro Mediavilla 
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      Title: Analysis of pfhrp2 and pfhrp3 gene deletions, and the structure and variability of PfHRP2 and PfHRP3 proteins: implications for the performance of malaria rapid diagnostic tests in Cubal, Angola
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study population and sample collection
         Item: 
          Title: Rapid diagnostic test
         Item: 
          Title: Analysis of deletions in the pfhrp2 and pfhrp3 genes
         Item: 
          Title: Protein study
          Children: 
           Item: 
            Title: Sequencing of exon 2 of pfhrp2 and pfhrp3
           Item: 
            Title: Amino acid sequence analysis
           Item: 
            Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Characteristics of the study population
         Item: 
          Title: Malaria diagnosis and identification of Plasmodium falciparum
         Item: 
          Title: Deletions in pfhrp2 and pfhrp3
          Children: 
           Item: 
            Title: Deletions of exons 1–2 and 2
           Item: 
            Title: Characteristics of the exon 1–2 deletions of pfhrp2 and pfhrp3
         Item: 
          Title: Analysis of the protein sequences of PfHRP2 and PfHRP3
          Children: 
           Item: 
            Title: Nucleotide and amino acid sequences
           Item: 
            Title: Histidine-rich repeat patterns
            Children: 
             Item: 
              Title: PfHRP2 
             Item: 
              Title: PfHRP3 
             Item: 
              Title: RDT sensitivity 
           Item: 
            Title: Candidate epitopes to be recognized by the MAbs used in RDTs
            Children: 
             Item: 
              Title: PfHRP2 
             Item: 
              Title: PfHRP3 
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Deletions in pfhrp2 and pfhrp3
         Item: 
          Title: Analysis of PfHRP2 and PfHRP3 variability and its relationship to RDT sensitivity
          Children: 
           Item: 
            Title: Histidine-rich repeats patterns
           Item: 
            Title: Candidate epitopes to be recognized by the MAbs used in RDT
       Item: 
        Title: Limitations of this study
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
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    Subject: Malaria Journal, https://doi.org/10.1186/s12936-025-05523-2
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   Type: CRC32
  Checksum: 78dcbcc861c664e23574bd3034df23d4
   Type: MD5
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