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Title:           Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
Subject:         Nature Communications, doi:10.1038/s41467-025-65490-9
Keywords:        
Author:          Rita Reig-Viader
Creator:         Springer
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      Title: Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
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        Title: Results
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         Item: 
          Title: Isolation of synaptic proteins from microscopic brain regions
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         Item: 
          Title: High similarity in the composition of trisynaptic circuit synapses
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         Item: 
          Title: Identification and validation of differentially expressed synaptic proteins
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         Item: 
          Title: Contribution of gene expression to synaptic proteome diversity
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         Item: 
          Title: High diversity in the molecular mechanism operating at different synapses
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         Item: 
          Title: AMPAR trafficking, actin dynamics and energy metabolism regulated in CA3-CA1 synapses
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         Item: 
          Title: Control over metabotropic signaling, translation and neurofilaments in DG-CA3 synapses
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         Item: 
          Title: A unique extracellular matrix at EC-DG synapses
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         Item: 
          Title: Different neuronal expression of genes related to glutamate receptors
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         Item: 
          Title: Genes related to glutamatergic signaling drive neuronal classifications
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        Title: Discussion
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       Item: 
        Title: Methods
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          Title: Animal handling
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         Item: 
          Title: Mouse brain dissection
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         Item: 
          Title: Laser-capture microdissection of hippocampal neuropile
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         Item: 
          Title: Isolation of synaptic fractions from laser-capture microdissected tissue
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         Item: 
          Title: Isolation of synaptic fractions from hippocampal subfields
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         Item: 
          Title: Isolation of synaptic fractions by differential ultracentrifugation
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          Title: Protein electrophoresis and immunoblot
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         Item: 
          Title: Sample processing for mass spectrometry
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         Item: 
          Title: Mass spectrometry analysis of tryptic peptides
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          Title: Database search of mass spectrometry data
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         Item: 
          Title: Criteria for protein identification by mass spectrometry data
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          Title: Peptide and protein quantification
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          Title: Tissue processing for double immunofluorescence analysis
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          Title: Double immunofluorescence in adult mouse brain sections
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          Title: Slice preparation for whole-cell electrophysiological recordings
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         Item: 
          Title: Whole-cell recordings
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         Item: 
          Title: Allen Brain Atlas RNA in situ hybridization (ISH) data analysis
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         Item: 
          Title: Pathway enrichment analysis
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         Item: 
          Title: Analysis of single cell RNA-sequencing data from the Allen Brain Cell Atlas
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          Title: General statistics
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         Item: 
          Title: Permutation test
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         Item: 
          Title: Uniform Manifold Approximation and Projection (U-MAPS)
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         Item: 
          Title: Gene classification using machine learning
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          Title: Reporting summary
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        Title: Data availability
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       Item: 
        Title: Code availability
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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       Item: 
        Title: Competing interests
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    Title: Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
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