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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Methods Destination: mk:H1_2 Children: Item: Title: 2.1 Participants Destination: mk:H2_1 Children: Item: Title: 2.1.1 Magnetic resonance imaging acquisition Destination: mk:H3_2 Item: Title: 2.1.2 Genotyping, genetic quality control and imputation Destination: mk:H3_3 Item: Title: 2.1.3 Genetic predisposition to Alzheimer’s disease Destination: mk:H3_4 Item: Title: 2.2 Statistical analysis Destination: mk:H2_5 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Descriptives Destination: mk:H2_6 Children: Item: Title: 3.1.1 Baseline analysis Destination: mk:H3_7 Item: Title: 3.2 Longitudinal analysis of hippocampal trajectories Destination: mk:H2_8 Children: Item: Title: 3.2.1 Characterization of annual volume changes in the hippocampus Destination: mk:H3_9 Item: Title: 3.2.2 Impact of genetic predisposition to AD on hippocampal trajectories Destination: mk:H3_10 Item: Title: 3.2.3 Diagnostic group-related differences in genetic effect on hippocampal trajectories Destination: mk:H3_11 Item: Title: 3.2.4 Sex-related differences in genetic effect on hippocampal trajectories Destination: mk:H3_12 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Acknowledgements Destination: mk:HH1_4 Item: Title: Appendix A Supplementary data Destination: mk:H1_7 Item: Title: Data availability Destination: datalink5 Item: Title: References Destination: mk:HH2_1 Info: Title: Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment Author: for the ADNI Subject: NeuroImage: Clinical, 48 (2025) 103889. doi:10.1016/j.nicl.2025.103889 Keywords: APOE,Genetic risk,Hippocampal atrophy,Mild cognitive 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NeuroImage: Clinical, 48 (2025) 103889. doi:10.1016/j.nicl.2025.103889 APOE Genetic risk Hippocampal atrophy Mild cognitive impairment Protein quantitative trait loci Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment for the ADNI Natalia Vilor-Tejedor Albert Rodrigo Patricia Genius Blanca Rodríguez-Fernández Federica Anastasi Wiesje Pelkmans Arcadi Navarro Hieab H. Adams Laura Wisse Juan D. Gispert Tavia E. Evans VoR 14th October 2025 Acrobat Distiller 8.1.0 (Windows) APOE,Genetic risk,Hippocampal atrophy,Mild cognitive impairment,Protein quantitative trait loci 14th October 2025 7.0.1 10.1016/j.nicl.2025.103889 noindex journal © 2025 The Author(s). Published by Elsevier Inc. 2025-01-01 14 October 2025 10.1016/j.nicl.2025.103889 2213-1582 103889 NeuroImage: Clinical 103889 https://doi.org/10.1016/j.nicl.2025.103889 48 https://www.elsevier.com/tdm/tdmrep-policy.json 1 2025-09-22T20:53:21 Elsevier 2025-10-14T13:40:42 2025-10-14T13:40:42 uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 138, 576, 142, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 145, 576, 149, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 152, 576, 155, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 158, 576, 162, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 165, 576, 169, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 247, 576, 251, 587 Flags: Print Destination: 2573 Annotation: Subtype: Link Rect: 254, 576, 258, 587 Flags: Print Destination: 2573 Annotation: 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