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Title:           Potential Biomarkers of Therapeutic Response to ECP in Solid Organ Transplantation
Subject:         DOI: 10.1097/TXD.0000000000001817
Transplantation Direct, Volume. 11, Issue. 9, 2 September 2025
Abstract. One of the major hurdles in solid organ transplantation is graft rejection, which must be prevented with lifelong general immunosuppression. However, modern maintenance immunosuppression is accompanied by serious side effects, such as an increased risk of infection and malignancies. The search for alternative therapies specifically controlling allogeneic responses is fueling renewed interest in extracorporeal photopheresis (ECP). Despite guideline indications for ECP in cardiothoracic transplantation, potential applications in liver and kidney transplantation have not been adequately investigated. Presently, limited understanding of the pharmacodynamic effects of ECP and lack of consensus biomarkers are hindering the development of standardized multiparametric assays to assess patient responses. This review explores current knowledge about immune responses after ECP in transplant recipients and collates a set of biomarkers associated with favorable treatment responses.
Author:          Hendrik Veltman 
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        Title: COMPOSITION OF PHERESATES AND ITS SYSTEMIC EFFECTS
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        Title: IMMUNE MODULATORY EFFECTS OF ECP IN SOT
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        Title: COMPOSITION OF PHERESATES AND ITS SYSTEMIC EFFECTS
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       Contents: Figure 1). To these WBCs,  8-methoxypsoralen (8-MOP) is then added, which binds intercalates into DNA, sensitizing cells to U嘀䄀 氀椀最栀琀⸀ 伀渀 唀嘀䄀 椀爀爀愀搀椀愀琀椀漀渀Ⰰ 㠀ⴀ䴀伀倀 昀漀爀洀猀 挀漀瘀愀氀攀渀琀 䐀一䄀 愀搀搀甀挀琀猀 琀栀愀琀 爀攀猀甀氀琀 椀渀 搀漀甀戀氀攀ⴀ猀琀爀愀渀搀攀搀 䐀一䄀 戀爀攀愀欀猀Ⰰ 眀栀椀挀栀 琀爀椀最最攀爀 愀瀀漀瀀琀漀猀s in treated cells. The resulting mixture of living and dying leuko-cytes, as well as the conditioned plasma in which they are 猀甀猀ⴀ瀀攀渀搀攀搀Ⰰ 椀猀 挀愀氀氀攀搀 愀†ᰀ瀀栀漀琀漀瀀栀攀爀攀猀愀琀攀⸠ᴀ 吀栀椀猀 椀洀洀甀渀漀氀漀最椀挀愀氀氀礀 挀漀洀瀀氀攀砀 瀀爀漀搀甀挀琀 椀猀 琀栀攀渀 爀攀椀渀昀甀猀攀搀 椀渀琀漀 瀀愀琀椀攀渀琀猀⸀㌩⽄敳琨㈲彔塄ⴲ〲㐭〲㘵⹩湤携䅮捨潲‸㨳〹
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       Contents: Figure 1). To these WBCs,  8-methoxypsoralen (8-MOP) is then added, which binds intercalates into DNA, sensitizing cells to U嘀䄀 氀椀最栀琀⸀ 伀渀 唀嘀䄀 椀爀爀愀搀椀愀琀椀漀渀Ⰰ 㠀ⴀ䴀伀倀 昀漀爀洀猀 挀漀瘀愀氀攀渀琀 䐀一䄀 愀搀搀甀挀琀猀 琀栀愀琀 爀攀猀甀氀琀 椀渀 搀漀甀戀氀攀ⴀ猀琀爀愀渀搀攀搀 䐀一䄀 戀爀攀愀欀猀Ⰰ 眀栀椀挀栀 琀爀椀最最攀爀 愀瀀漀瀀琀漀猀s in treated cells. The resulting mixture of living and dying leuko-cytes, as well as the conditioned plasma in which they are 猀甀猀ⴀ瀀攀渀搀攀搀Ⰰ 椀猀 挀愀氀氀攀搀 愀†ᰀ瀀栀漀琀漀瀀栀攀爀攀猀愀琀攀⸠ᴀ 吀栀椀猀 椀洀洀甀渀漀氀漀最椀挀愀氀氀礀 挀漀洀瀀氀攀砀 瀀爀漀搀甀挀琀 椀猀 琀栀攀渀 爀攀椀渀昀甀猀攀搀 椀渀琀漀 瀀愀琀椀攀渀琀猀⸀㌩⽄敳琨㈲彔塄ⴲ〲㐭〲㘵⹩湤携䅮捨潲‹㨳㄰
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  Checksum: f9bbe8ee
   Type: CRC32
  Checksum: 8ab928d83d200680d68ca42463e9e6d1
   Type: MD5
  Checksum: b595d3936f4df92b76a5ded0c5d73d5f46b9df85
   Type: SHA-1
  Checksum: 7c11520c875e001366e3f980b4df8844318cfee3c90392ce0cba73a9ee78f1ae
   Type: SHA-256