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Destination: mk:title Children: Item: Title: INTRODUCTION Destination: mk:H1_1 Item: Title: MATERIALS AND METHODS Destination: mk:H1_2 Children: Item: Title: Cells lines and cultures Destination: mk:H2_1 Item: Title: CRISPR/Cas9 Destination: mk:H2_2 Item: Title: In vivo mice models Destination: mk:H2_3 Item: Title: Studies with patients Destination: mk:H2_4 Item: Title: 3D Cultures Destination: mk:H2_5 Item: Title: In vivo chicken embryo model Destination: mk:H2_6 Item: Title: Generation of conditioned media Destination: mk:H2_7 Item: Title: Immunoprecipitation assay Destination: mk:H2_8 Item: Title: RNA-Seq data processing and analysis Destination: mk:H2_9 Item: Title: Principal component and differential gene expression analysis Destination: mk:H2_10 Item: Title: Gene ontology overrepresentation analyses Destination: mk:H2_11 Item: Title: Gene set enrichment analysis Destination: mk:H2_12 Item: Title: Adhesion assays Destination: mk:H2_13 Item: Title: Statistical analysis Destination: mk:H2_14 Item: Title: RESULTS Destination: mk:H1_3 Children: Item: Title: NRP2 Promotes proliferation and cell cycle progression concomitantly with downregulation of dormancy and cell cycle regulators Destination: mk:H2_15 Item: Title: NRP2 Deletion inhibits tumor-initiation capacity in vitro and blocks tumor growth in vivo Destination: mk:H2_16 Item: Title: NRP2 upregulation in lung DTCs drives lung micro-metastases emergence Destination: mk:H2_17 Item: Title: Lung fibroblasts and macrophages-derived TGFβ1 induces DTCs NRP2 expression Destination: mk:H2_18 Item: Title: NRP2 deletion triggers quiescence in lung DTCs in vivo and inhibits lung metastases Destination: mk:H2_19 Item: Title: NRP2 deletion in head and neck cancer cells upregulates cell cycle regulators expression and inhibits adhesion to the extra ... Destination: mk:H2_20 Item: Title: High levels of NRP2 negatively correlate with BrCa and HNSCC patients’ distant metastases free survival Destination: mk:H2_21 Item: Title: DISCUSSION Destination: mk:H1_4 Item: Title: Data and materials availability Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Acknowledgements Destination: mk:HH1_3 Item: Title: Supplementary materials Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth Author: L Recalde-Percaz Subject: Neoplasia, 68 (2025) 101220. doi:10.1016/j.neo.2025.101220 Keywords: Neuropilins,dormancy,disseminated tumor cells,TGF?,metastasis,breast cancer,head and neck cancer Creator: Elsevier Producer: Acrobat 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Neoplasia, 68 (2025) 101220. doi:10.1016/j.neo.2025.101220 Neuropilins dormancy disseminated tumor cells TGF? metastasis breast cancer head and neck cancer Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth L Recalde-Percaz I de la Guia-Lopez P Linzoain-Agos A Noguera-Castells M Rodrigo-Faus P Jauregui A Lopez-Plana P Fernández-Nogueira M Iniesta-González M Cueto-Remacha S Manzano R Alonso N Moragas C Baquero N Palao E Dalla FX Avilés-Jurado I Vilaseca X León-Vintró M Camacho G Fuster J Alcaraz J Aguirre-Ghiso P Gascón A Porras A Gutiérrez-Uzquiza N Carbó P Bragado VoR 25th February 2026 Acrobat Distiller 8.1.0 (Windows) Neuropilins,dormancy,disseminated tumor cells,TGF?,metastasis,breast cancer,head and neck cancer 25th February 2026 sciencedirect.com elsevier.com true 2010-04-23 7.0.1 10.1016/j.neo.2025.101220 noindex journal © 2025 The Authors. 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