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Destination: slink6 Item: Title: Increased MYC transcriptional signature predicts poor response to PARPis in patients with metastatic breast cancer Destination: slink7 Item: Title: Discussion Destination: flink8 Children: Item: Title: Limitations of the study Destination: slink9 Item: Title: Resource availability Destination: flink10 Children: Item: Title: Lead contact Destination: slink11 Item: Title: Materials availability Destination: slink12 Item: Title: Data and code availability Destination: slink13 Item: Title: Acknowledgments Destination: flink14 Item: Title: Author contributions Destination: flink15 Item: Title: Declaration of interests Destination: flink16 Item: Title: Supplemental information Destination: falink17 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink18 Children: Item: Title: Key resources table Destination: slink19 Item: Title: Experimental model and study participant details Destination: slink20 Children: Item: Title: Cell lines Destination: tlink1 Item: Title: Animal studies Destination: tlink2 Item: Title: Human samples Destination: tlink3 Item: Title: Method details Destination: slink21 Children: Item: Title: Microarray analysis and RNA sequencing Destination: tlink4 Item: Title: Western blots Destination: tlink5 Item: Title: Flow cytometry Destination: tlink6 Item: Title: Drug sensitivity and synergy analysis Destination: tlink7 Item: Title: Immunofluorescence Destination: tlink8 Item: Title: RAD51 and BRCA1 c-terminus score Destination: tlink9 Item: Title: Digital spatial profiling Destination: tlink10 Item: Title: Quantification and statistical analysis Destination: slink22 Info: Title: MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer Author: Fabio Giuntini Subject: CellReports, 44 (2025) 116604. doi:10.1016/j.celrep.2025.116604 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Sun Dec 21 12:20:59 CET 2025 ModDate: Mon Dec 22 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application/pdf doi:10.1016/j.celrep.2025.116604 MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer Fabio Giuntini Íñigo González-Larreategui Andrea Herencia-Ropero Silvia Casacuberta-Serra Mariano F. Zacarías-Fluck Magdalena Arnal Flaminia Pedretti Sandra Martínez-Martín Hugo Thabussot Virginia Castillo Cano Judit Grueso Laia Foradada Erika Serrano Sergio López-Estévez Olga Rodriguez Marta Guzman Adela Rodriguez-Hernandez Fara Brasó-Maristany Alba Llop-Guevara Judith Balmaña Lara Nonell Aleix Prat Violeta Serra Marie-Eve Beaulieu Jonathan R. Whitfield Daniel Massó-Vallés Laura Soucek Omomyc TNBC PARPi DNA damage therapy resistance CellReports, 44 (2025) 116604. doi:10.1016/j.celrep.2025.116604 The Authors journal CellReports © 2025 The Authors. Published by Elsevier Inc. 2211-1247 44 12 23 December 2025 2025-12-23 116604 116604 10.1016/j.celrep.2025.116604 https://doi.org/10.1016/j.celrep.2025.116604 2010-04-23 true 10.1016/j.celrep.2025.116604 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.celrep.2025.116604 noindex true 2010-04-23 true PStill version 1.84.42 sciencedirect.com elsevier.com Elsevier 2025-12-21T16:20:59+05:30 2025-12-22T15:39:47+05:30 2025-12-22T15:39:47+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json PDFlib+PDI 10.0.2p2 (C++/Win64) uuid:cbd04e37-9dad-4a4b-bb1e-c020cc072164 uuid:637a3ccb-2d71-4885-916b-378ccc0269ea http://creativecommons.org/licenses/by/4.0/ Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 354, 503, 435, 513 Flags: Print Annotation: Subtype: Link Contents: Rect: 100, 48, 273, 56 Flags: Print Annotation: Subtype: Link Contents: Rect: 53, 58, 69, 74 Flags: Print Page: Sequence: 2 Annotations: Annotation: Subtype: Link Contents: Rect: 53, 681, 53, 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