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Title:           Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection
Subject:         Aran A, Lázaro G, Marco V, Peg V, Faus M, Garrigós L, Pérez-García J, Cortés J and Martí M (2025) Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection. Front. Immunol. 16:1699262. doi: 10.3389/fimmu.2025.1699262
Keywords:        breast cancer; TIL; tumor-infiltrating lymphocytes; immunotherapy; TCR repertoire
Author:          Andrea Aran
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      Title: Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection
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       Item: 
        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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        Children: 
         Item: 
          Title: 2.1 Breast cancer biopsies
          Destination: s2_1
         Item: 
          Title: 2.2 Immunohistochemistry
          Destination: s2_2
         Item: 
          Title: 2.3 T cell cultures
          Destination: s2_3
         Item: 
          Title: 2.4 Flow cytometry
          Destination: s2_4
         Item: 
          Title: 2.5 Cytokine analysis
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         Item: 
          Title: 2.6 TCR library preparation
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         Item: 
          Title: 2.7 TCR repertoire analysis
          Destination: s2_7
         Item: 
          Title: 2.8 Statistical analysis and figures
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       Item: 
        Title: 3 Results
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        Children: 
         Item: 
          Title: 3.1 The percentage of CD3+ TILs in early explant cultures reflects IHC-based high versus low infiltration but is not associated with specific CD4+ or CD8+ subpopulations
          Destination: s3_1
         Item: 
          Title: 3.2 The percentage of CD4+ TILs in early explant cultures is inversely related to the presence of secreted molecules with cytotoxic functions, especially under low infiltration levels
          Destination: s3_2
         Item: 
          Title: 3.3 Characterization of the TCR repertoire of TILs in the early explant cultures
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         Item: 
          Title: 3.4 CD4+ TIL percentages in early explant cultures are inversely related to TCR repertoire diversity
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       Item: 
        Title: 4 Discussion
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       Item: 
        Title: Data availability statement
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       Item: 
        Title: Ethics statement
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: Generative AI statement
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        Title: Publisher’s note
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       Item: 
        Title: Supplementary material
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        Title: References
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    Title: Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection
    Author: Andrea Aran
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  Checksum: 3cd12ae6
   Type: CRC32
  Checksum: f79ec11dcad64e73b1207d533b2a8f3b
   Type: MD5
  Checksum: 25b54abea21bd03c35871f4d7c8ed906a2cf53ad
   Type: SHA-1
  Checksum: 8ddfbc29c3b52cfd6c2357385a25b8604a10515e50e583427da57a257e778034
   Type: SHA-256