80fc9d81633befbeb58a6f846ae24bca wjg-31-45-112618.pdf 4146cea8d6541e5ca0172710180f31f1f52a7569 wjg-31-45-112618.pdf edb6d78c475689574fb8833d41fd4941e58ee53109db1723e97e62fc75cb0b7e wjg-31-45-112618.pdf Title: Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease Author: Albert Boronat-Toscano, Maria Isabel Queipo-Ortuño, Diandra Monfort-Ferré, Roger Suau, Irene Vañó-Segarra, Gemma Valldosera, Claudia Cepero, Brenno Astiarraga, Laura Clua-Ferré, Isaac Plaza-Andrade, Lucía Aranega-Martín, Lidia Cabrinety, Carme Abadia de Barbarà, Daniel Castellano-Castillo, Alicia Moliné, Aleidis Caro, Eugeni Domènech, Jose Francisco Sánchez-Herrero, Robert Benaiges-Fernandez, Sonia Fernández-Veledo, Joan Vendrell, Iris Ginés, Lauro Sumoy, Josep Manyé, Margarita Menacho, Carolina Serena Creator: Baishideng Publishing Group Inc. 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Rel. 1.12.4 (2023-03-16) LastModified: 2026-04-20 16:13:25 CEST Size: 4103147 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Study design and patients Item: Title: Isolation of peripheral blood mononuclear cells Item: Title: Real time quantitative polymerase chain reaction gene expression profiling Item: Title: Validation design of an independent post-surgical recurrence cohort Item: Title: Fecal microbiome analysis Item: Title: Bioinformatics analysis Item: Title: Circulating succinate measurement Item: Title: Sample stratification by Dialister or Phascolarctobacterium succinotypes Item: Title: Statistical analysis Item: Title: RESULTS Children: Item: Title: Alterations in microbial diversity and composition in active and inactive CD patients Item: Title: Circulating succinate levels are elevated in CD patients and associate with inflammation Item: Title: Circulating succinate levels correlates with a specific microbial signature Item: Title: Dialister-succinotypes correlate with circulating succinate levels associate with disease activity Item: Title: Dialister presence in the intestinal mucosa may be POR indicator in CD patients Item: Title: Functional analysis identifies succinate as a key player in CD Item: Title: DISCUSSION Item: Title: CONCLUSION Item: Title: ACKNOWLEDGEMENTS Item: Title: FOOTNOTES Item: Title: REFERENCES Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 563 ImageHeight: 367 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 675 ImageHeight: 675 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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