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     Item: 
      Title: Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Samples
         Item: 
          Title: Variant quality control
         Item: 
          Title: Variant annotation
       Item: 
        Title: Prioritization of rare missense variants
        Children: 
         Item: 
          Title: Rare variant association with Alzheimer’s disease
         Item: 
          Title: Age at onset curves
         Item: 
          Title: Effect of APOE
       Item: 
        Title: Results
       Item: 
        Title: PTV, protein truncating variants
       Item: 
        Title: HPV, high-priority missense variants
        Children: 
         Item: 
          Title: VPS10p-domain (res 82–617) and 10CC-domain (res 618–753)
         Item: 
          Title: YWTD-domain (res 754–1013) and EGF-domain (res 1014–1074)
         Item: 
          Title: CR-domain (res 1075–1550): calcium-cage and cysteines
         Item: 
          Title: 3Fn-domain (res 1551–2121)
         Item: 
          Title: Transmembrane and tail domain (res 2161–2214)
       Item: 
        Title: Effect of APOE-ε4 allele
       Item: 
        Title: MPVs, LPVs, NPVs and variants with MAF > 0.05%
       Item: 
        Title: Comparison of prioritization scheme vs using only REVEL scores or AlphaMissense
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        Title: Discussion
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        Title: Conclusion
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        Title: References
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