be0f01bbc71c4751b772b5c972a46d24  COMBIO_a2025n8p1643.pdf
a6324d3005df7dabdd136dd07bafa454b81f3262  COMBIO_a2025n8p1643.pdf
bdbaf67462378210b2520c2e3c39b5509077dc8c70783723a38083cfc5c2536d  COMBIO_a2025n8p1643.pdf

Title:           Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters
Subject:         Communications Biology, doi:10.1038/s42003-025-09034-3
Keywords:        
Author:          Núria Pedreño-López
Creator:         Springer
Producer:        iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Fri Oct 24 20:21:45 2025 CEST
ModDate:         Mon Nov 24 14:54:06 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           17
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1840389 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
BOAFNL+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no     904  0
BOAJCA+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no      49  0
BOAJCB+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes     50  0
BOAJCC+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no      51  0
BOAJDC+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes     52  0
BOAJDD+AdvOTf0129623+20              Type 1C           WinAnsi          yes yes no      53  0
BOAFNM+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     905  0
BOAFNN+AdvOT0f7080ee                 Type 1C           WinAnsi          yes yes no     906  0
BOAFNO+AdvOT34fe1490.B               Type 1C           WinAnsi          yes yes no      56  0
BOAFNP+AdvOTf0129623                 Type 1C           WinAnsi          yes yes no      57  0
BOAGDN+AdvOTf94803d4                 Type 1C           WinAnsi          yes yes no      58  0
BOAGDO+AdvOTfbba3ace.B               Type 1C           WinAnsi          yes yes no     907  0
BOAJBO+AdvOTf0129623+fb              Type 1C           Custom           yes yes yes    385  0
BOAJBP+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no      59  0
BOAJKC+AdvOT34fe1490.B+fb            Type 1C           Custom           yes yes yes     54  0
BOAJLC+AdvOT6601a1b9.BI              Type 1C           WinAnsi          yes yes no      55  0
BOAJMD+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no      71  0
BOAJME+AdvOTb65e897d.B+fb            Type 1C           Custom           yes yes yes     72  0
BOAJOE+Verdana                       Type 1C           WinAnsi          yes yes no      73  0
BOAJOF+ArialMT                       Type 1C           Custom           yes yes yes     74  0
BOAKIC+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      99  0
BOBBCL+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     364  0
BOBBCM+AdvOTf94803d4+fb              Type 1C           Custom           yes yes yes    365  0
BOBBEM+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     382  0
BOBBEN+AdvOT3a037357.I               Type 1C           WinAnsi          yes yes no     383  0
BOBBFN+AdvOT46dcae81+03              Type 1C           Custom           yes yes yes    384  0
BOBBGO+AdvOT46dcae81+01              Type 1C           Custom           yes yes yes    401  0
BOBBIO+AdvOT34fe1490.B+20            Type 1C           WinAnsi          yes yes no     419  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-07-02 04:08:55 CEST
 RepresentationInformation: COMBIO_a2025n8p1643.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-07-01 13:31:17 CEST
  Size: 1840389
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1054
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Cohort description
          Destination: B1
         Item: 
          Title: Severe COVID-19 is associated with greater levels of SARS-CoV-2-specific antibodies compared to mild disease
          Destination: B2
         Item: 
          Title: The avidity of the anti-SARS-CoV-2 humoral response varies depending on the antigen, and is not associated with disease severity
          Destination: B3
         Item: 
          Title: Enhanced Fc-dependent activity of RBD- and S2-specific antibodies in individuals with severe COVID-19 may result from elevated plasma antibody levels
          Destination: B4
         Item: 
          Title: Infusion of purified RBD-depleted human IgG and IgA from COVID-19 patients induce an early transient weight loss in SARS-CoV-2-challenged golden Syrian hamsters followed by a faster disease recovery
          Destination: B5
         Item: 
          Title: S2 vaccination induced an early and transient weight loss in male GSHs after SARS-CoV-2 challenge but protected animals against disease
          Destination: B6
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Materials and methods
        Destination: A3
        Children: 
         Item: 
          Title: Study design and participants
          Destination: B7
         Item: 
          Title: Antigen-specific human IgG, IgA, and IgM ELISA
          Destination: B8
         Item: 
          Title: Antigen-specific human IgG and IgA Avidity ELISA
          Destination: B9
         Item: 
          Title: Pseudovirus-based neutralization assay
          Destination: B10
         Item: 
          Title: Antibody-dependent cellular phagocytosis
          Destination: B11
         Item: 
          Title: Antibody-dependent NK cell activation
          Destination: B12
         Item: 
          Title: Macrophage cytokine and chemokine measurement
          Destination: B13
         Item: 
          Title: Animal studies
          Destination: B14
          Children: 
           Item: 
            Title: S2 immunization
            Destination: C1
           Item: 
            Title: S2 production and purification
            Destination: C2
           Item: 
            Title: Human antibody administration
            Destination: C3
           Item: 
            Title: Sequential human Ig purification and RBD-specific Ig depletion
            Destination: C4
           Item: 
            Title: Antigen-specific GSH IgG ELISA
            Destination: C5
           Item: 
            Title: Quantification of human IgG- or IgA-specific antibodies in GSH
            Destination: C6
           Item: 
            Title: Measurement of viral RNA load (RT-qPCR)
            Destination: C7
           Item: 
            Title: Pathology and immunohistochemistry
            Destination: C8
         Item: 
          Title: Statistics and reproducibility
          Destination: B15
         Item: 
          Title: Reporting summary
          Destination: B16
       Item: 
        Title: Data availability
        Destination: A4
       Item: 
        Title: References
        Destination: A5
       Item: 
        Title: Acknowledgements
        Destination: A6
       Item: 
        Title: Author contributions
        Destination: A7
       Item: 
        Title: Competing interests
        Destination: A8
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters
    Author: Núria Pedreño-López
    Subject: Communications Biology, doi:10.1038/s42003-025-09034-3
    Keywords: 
    Creator: Springer
    Producer: iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Fri Oct 24 20:51:45 CEST 2025
    ModDate: Mon Nov 24 14:54:06 CET 2025
   ID: 0x9b4e101239463198771cacd21b57feac, 0xa4357496f2ef49095224a18e5e3a13ff
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1659
      ImageHeight: 388
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1599
      ImageHeight: 357
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: BOBBFN+AdvOT46dcae81+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BOBBFN+AdvOT46dcae81+03
       Flags: Symbolic
       FontBBox: -31, -208, 739, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJBO+AdvOTf0129623+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BOAJBO+AdvOTf0129623+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJMD+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 44
      LastChar: 124
      FontDescriptor: 
       FontName: BOAJMD+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAFNL+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 97
      LastChar: 117
      FontDescriptor: 
       FontName: BOAFNL+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJME+AdvOTb65e897d.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BOAJME+AdvOTb65e897d.B+fb
       Flags: Symbolic
       FontBBox: 0, -10, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAFNM+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 98
      LastChar: 121
      FontDescriptor: 
       FontName: BOAFNM+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJOE+Verdana
      FontSubset: true
      FirstChar: 32
      LastChar: 115
      FontDescriptor: 
       FontName: BOAJOE+Verdana
       Flags: Nonsymbolic
       FontBBox: -560, -303, 1523, 1051
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAFNN+AdvOT0f7080ee
      FontSubset: true
      FirstChar: 108
      LastChar: 108
      FontDescriptor: 
       FontName: BOAFNN+AdvOT0f7080ee
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJOF+ArialMT
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: BOAJOF+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAGDO+AdvOTfbba3ace.B
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: BOAGDO+AdvOTfbba3ace.B
       Flags: Nonsymbolic
       FontBBox: -31, -229, 968, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBGO+AdvOT46dcae81+01
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BOBBGO+AdvOT46dcae81+01
       Flags: Symbolic
       FontBBox: -41, -218, 854, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAKIC+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 43
      FontDescriptor: 
       FontName: BOAKIC+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBIO+AdvOT34fe1490.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: BOBBIO+AdvOT34fe1490.B+20
       Flags: Nonsymbolic
       FontBBox: -156, -166, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBCL+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: BOBBCL+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBCM+AdvOTf94803d4+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BOBBCM+AdvOTf94803d4+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJCA+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 50
      LastChar: 121
      FontDescriptor: 
       FontName: BOAJCA+AdvOT7d6df7ab.I
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJCB+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: BOAJCB+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJCC+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: BOAJCC+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJDC+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: BOAJDC+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJDD+AdvOTf0129623+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: BOAJDD+AdvOTf0129623+20
       Flags: Nonsymbolic
       FontBBox: -156, -145, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJKC+AdvOT34fe1490.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BOAJKC+AdvOT34fe1490.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 552, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BOAJLC+AdvOT6601a1b9.BI
      FontSubset: true
      FirstChar: 110
      LastChar: 110
      FontDescriptor: 
       FontName: BOAJLC+AdvOT6601a1b9.BI
       Flags: Nonsymbolic
       FontBBox: -125, -208, 1020, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAFNO+AdvOT34fe1490.B
      FontSubset: true
      FirstChar: 38
      LastChar: 250
      FontDescriptor: 
       FontName: BOAFNO+AdvOT34fe1490.B
       Flags: Nonsymbolic
       FontBBox: -52, -208, 937, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAFNP+AdvOTf0129623
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: BOAFNP+AdvOTf0129623
       Flags: Nonsymbolic
       FontBBox: -52, -208, 906, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAGDN+AdvOTf94803d4
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: BOAGDN+AdvOTf94803d4
       Flags: Nonsymbolic
       FontBBox: -41, -218, 937, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOAJBP+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 215
      FontDescriptor: 
       FontName: BOAJBP+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBEM+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: BOBBEM+AdvOTa20b42a7
       Flags: Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BOBBEN+AdvOT3a037357.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: BOBBEN+AdvOT3a037357.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
        xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
        xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#"
      dc:format="application/pdf"
      dc:identifier="doi:10.1038/s42003-025-09034-3"
      prism:doi="10.1038/s42003-025-09034-3"
      prism:url="http://dx.doi.org/10.1038/s42003-025-09034-3"
      prism:aggregationType="journal"
      prism:publicationName="Communications Biology"
      prism:copyright="© 2025, The Author(s)"
      prism:issn="2399-3642"
      pdfx:doi="10.1038/s42003-025-09034-3"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="True"
      crossmark:DOI="10.1038/s42003-025-09034-3"
      xmp:CreatorTool="Springer"
      xmp:ModifyDate="2025-11-24T14:54:06+01:00"
      xmp:CreateDate="2025-10-24T23:51:45+05:30"
      xmp:MetadataDate="2025-11-24T14:54:06+01:00"
      xmpRights:Marked="True"
      pdf:Keywords=""
      pdf:Producer="iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      jav:journal_article_version="VoR"
      xmpMM:DocumentID="uuid:586eacbe-92e1-4d4d-b23a-5104fe4f3199"
      xmpMM:InstanceID="uuid:35802cae-0058-436e-9154-3330649054df"
      xmpMM:RenditionClass="default"
      xmpMM:VersionID="1"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li>Núria Pedreño-López</rdf:li>
          <rdf:li>Ferran Tarrés-Freixas</rdf:li>
          <rdf:li>Carla Usai</rdf:li>
          <rdf:li>Dalia Raïch-Regué</rdf:li>
          <rdf:li>Susana Benet</rdf:li>
          <rdf:li>Erola Ainsua-Enrich</rdf:li>
          <rdf:li>Julieta Carabelli</rdf:li>
          <rdf:li>Edwards Pradenas</rdf:li>
          <rdf:li>Carlos Ávila-Nieto</rdf:li>
          <rdf:li>Núria Roca</rdf:li>
          <rdf:li>Guillermo Cantero</rdf:li>
          <rdf:li>Mònica Pérez</rdf:li>
          <rdf:li>Maria Luisa Rodríguez de la Concepción</rdf:li>
          <rdf:li>Marina Matilla</rdf:li>
          <rdf:li>Boris Revollo</rdf:li>
          <rdf:li>Agnes Hernández</rdf:li>
          <rdf:li>Jorge Abad-Capa</rdf:li>
          <rdf:li>Beatriz Mothe</rdf:li>
          <rdf:li>Jose Moltó</rdf:li>
          <rdf:li>Lourdes Mateu</rdf:li>
          <rdf:li>Marta Massanella</rdf:li>
          <rdf:li>Nuria Izquierdo-Useros</rdf:li>
          <rdf:li>Julià Blanco</rdf:li>
          <rdf:li>Bonaventura Clotet</rdf:li>
          <rdf:li>Joaquim Segalés</rdf:li>
          <rdf:li>Júlia Vergara-Alert</rdf:li>
          <rdf:li>Jorge Carrillo</rdf:li>
        </rdf:Seq>
      </dc:creator>
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Springer US</rdf:li>
        </rdf:Bag>
      </dc:publisher>
      <dc:subject>
        <rdf:Bag/>
      </dc:subject>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Communications Biology, doi:10.1038/s42003-025-09034-3</rdf:li>
        </rdf:Alt>
      </dc:description>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:ba72b362-4ea9-4823-9703-543eebda3906"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-10-24T23:52:59+05:30"/>
        </rdf:Seq>
      </xmpMM:History>
      <sn:authorInfo>
        <rdf:Bag>
          <rdf:li
            author:name="Carla Usai"
            author:orcid="http://orcid.org/0000-0002-6373-2765"/>
          <rdf:li
            author:name="Dalia Raïch-Regué"
            author:orcid="http://orcid.org/0000-0001-7656-5700"/>
          <rdf:li
            author:name="Edwards Pradenas"
            author:orcid="http://orcid.org/0000-0001-5162-8920"/>
          <rdf:li
            author:name="Maria Luisa Rodríguez de la Concepción"
            author:orcid="http://orcid.org/0000-0002-6944-3462"/>
          <rdf:li
            author:name="Beatriz Mothe"
            author:orcid="http://orcid.org/0000-0001-9975-407X"/>
          <rdf:li
            author:name="Marta Massanella"
            author:orcid="http://orcid.org/0000-0002-3326-151X"/>
          <rdf:li
            author:name="Nuria Izquierdo-Useros"
            author:orcid="http://orcid.org/0000-0002-1039-1821"/>
          <rdf:li
            author:name="Julià Blanco"
            author:orcid="http://orcid.org/0000-0002-2225-0217"/>
          <rdf:li
            author:name="Bonaventura Clotet"
            author:orcid="http://orcid.org/0000-0003-3232-4598"/>
          <rdf:li
            author:name="Joaquim Segalés"
            author:orcid="http://orcid.org/0000-0002-1539-7261"/>
          <rdf:li
            author:name="Júlia Vergara-Alert"
            author:orcid="http://orcid.org/0000-0001-7484-444X"/>
          <rdf:li
            author:name="Jorge Carrillo"
            author:orcid="http://orcid.org/0000-0003-0221-5948"/>
        </rdf:Bag>
      </sn:authorInfo>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A structure containing the characteristics of a font used in a document"
                  pdfaProperty:name="Fonts"
                  pdfaProperty:valueType="Bag Font"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="A structure containing the characteristics of a font used in a document."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Font#"
                  pdfaType:prefix="stFnt"
                  pdfaType:type="Font"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright "
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;"
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;"
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn"
              pdfaSchema:schema="Springer Nature ORCID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."
                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li>
                  <rdf:Description
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author."
                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:type="AuthorInformation">
                  <pdfaType:field>
                    <rdf:Seq>
                      <rdf:li
                        pdfaField:description="Gives the name of an author."
                        pdfaField:name="name"
                        pdfaField:valueType="Text"/>
                      <rdf:li
                        pdfaField:description="Gives the ORCID of an author."
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"/>
                    </rdf:Seq>
                  </pdfaType:field>
                  </rdf:Description>
                </rdf:li>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 471, 563, 479, 595
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 130, 555, 133, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 229, 555, 232, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 233, 555, 236, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 238, 555, 241, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 289, 552, 290, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 289, 552, 290, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 298, 550, 300, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 290, 550, 298, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 298, 550, 299, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 299, 555, 302, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 303, 555, 306, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 390, 552, 391, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 552, 391, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 550, 401, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 550, 399, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 550, 400, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 555, 403, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 466, 555, 469, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 470, 555, 473, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 123, 542, 126, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 200, 542, 203, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 288, 539, 289, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 539, 289, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 297, 538, 299, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 289, 538, 297, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 297, 538, 298, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 298, 542, 301, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 383, 542, 386, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 438, 542, 441, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 442, 542, 445, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 117, 530, 120, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 121, 530, 124, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 187, 530, 190, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 192, 530, 195, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 371, 526, 373, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 526, 373, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 525, 383, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 373, 525, 380, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 525, 382, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 530, 385, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 450, 530, 453, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 95, 517, 98, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 100, 517, 103, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 183, 517, 186, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 266, 517, 269, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 334, 514, 335, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 334, 514, 335, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 343, 512, 345, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 335, 512, 343, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 343, 512, 344, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 517, 347, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 348, 517, 351, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 353, 517, 356, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 408, 517, 411, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 412, 517, 415, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 417, 517, 420, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 421, 517, 424, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 103, 504, 106, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 108, 504, 111, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 112, 504, 115, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 117, 504, 120, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 200, 501, 202, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 200, 501, 202, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 499, 212, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 499, 209, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 499, 211, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 211, 504, 214, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 215, 504, 218, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 322, 501, 323, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 501, 323, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 331, 499, 333, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 499, 331, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 331, 499, 332, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 332, 504, 335, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 336, 504, 339, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 341, 504, 344, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 400, 501, 402, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 501, 402, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 499, 412, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 499, 409, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 499, 411, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 411, 504, 414, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 415, 504, 418, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 420, 504, 423, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 424, 504, 427, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 122, 488, 123, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 122, 488, 123, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 131, 487, 133, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 123, 487, 131, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 131, 487, 132, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 492, 135, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 136, 492, 139, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 141, 492, 144, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 145, 492, 148, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 226, 488, 227, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 226, 488, 227, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 235, 487, 237, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 228, 487, 235, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 235, 487, 236, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 236, 492, 239, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 241, 492, 247, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 331, 488, 332, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 331, 488, 332, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 487, 342, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 333, 487, 340, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 487, 341, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 341, 492, 344, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 346, 492, 349, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 428, 488, 429, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 488, 429, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 487, 439, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 430, 487, 437, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 487, 438, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 492, 441, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 443, 492, 446, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 447, 492, 450, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 244, 234, 247, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 249, 234, 252, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 55, 202, 57, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 60, 202, 62, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 109, 180, 111, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 112, 180, 115, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 116, 180, 118, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 174, 170, 176, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 178, 170, 180, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 181, 170, 186, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 363, 266, 367, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 370, 266, 374, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 432, 234, 436, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 439, 234, 443, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 547, 223, 552, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 554, 223, 559, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 418, 212, 422, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 423, 212, 428, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 510, 212, 515, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 351, 202, 356, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 357, 202, 361, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 362, 202, 367, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 345, 191, 350, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 351, 191, 355, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 356, 191, 361, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 431, 138, 436, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 332, 48, 400, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 48, 471, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 281, 737, 285, 743
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 288, 737, 292, 743
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 64, 694, 69, 700
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 281, 684, 285, 689
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 288, 684, 292, 689
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 273, 662, 278, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 198, 652, 201, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 202, 652, 206, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 254, 641, 259, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 217, 630, 221, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 95, 587, 99, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 102, 587, 106, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 499, 443, 504, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 388, 358, 392, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 442, 261, 446, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 552, 144, 556, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 465, 122, 469, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 346, 101, 350, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 320, 47, 324, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 154, 141, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 280, 144, 284, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 159, 122, 163, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 83, 116, 88, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 224, 58, 228, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 219, 47, 223, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 325, 79, 329, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 443, 116, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 95, 379, 99, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 56, 240, 60, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 170, 197, 174, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 512, 486, 516, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 465, 401, 469, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 528, 315, 532, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 495, 272, 499, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 380, 208, 384, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 532, 122, 536, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 323, 79, 328, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 89, 134, 97
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 208, 61, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 218, 133, 222, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 119, 90, 123, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 514, 336, 518, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 405, 272, 410, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 323, 240, 327, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 378, 197, 382, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 546, 144, 550, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 446, 122, 451, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 323, 101, 327, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 451, 69, 455, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 162, 399, 259, 407
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 201, 219, 205, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 176, 186, 180, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 255, 165, 259, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 79, 133, 83, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 143, 69, 147, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 128, 47, 132, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 439, 176, 443, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 340, 101, 344, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 280, 73, 285, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 287, 73, 292, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 465, 138, 470, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 471, 138, 476, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 495, 105, 500, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 501, 105, 506, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 507, 105, 512, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 513, 105, 518, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 523, 63, 525, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 526, 63, 529, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 530, 63, 535, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 536, 63, 541, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 542, 63, 547, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 548, 63, 553, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 554, 63, 559, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 181, 684, 186, 689
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 196, 652, 198, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 199, 652, 204, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 280, 630, 285, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 189, 619, 194, 625
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 153, 609, 158, 614
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 271, 598, 276, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 187, 577, 192, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 66, 555, 71, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 72, 555, 77, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 94, 502, 99, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 101, 502, 106, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 287, 491, 292, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 159, 480, 164, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 120, 320, 125, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 255, 309, 260, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 178, 202, 183, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 198, 191, 203, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 268, 95, 273, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 274, 95, 279, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 233, 84, 236, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 237, 84, 242, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 243, 84, 248, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 471, 694, 476, 700
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 478, 641, 483, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 449, 619, 454, 625
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 338, 491, 343, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 543, 491, 546, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 447, 437, 452, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 379, 427, 384, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 535, 320, 540, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 514, 148, 519, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 165, 737, 170, 743
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 104, 272, 109, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 556, 673, 561, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 384, 470, 386, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 368, 138, 373, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 251, 252, 260
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 694, 137, 700
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 239, 512, 244, 518
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 252, 427, 258, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 391
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 490, 80, 494, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 511, 80, 515, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 572, 194, 580
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 722, 414, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 530, 560, 538
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 519, 342, 527
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 19, 130, 27
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: f729d541
   Type: CRC32
  Checksum: be0f01bbc71c4751b772b5c972a46d24
   Type: MD5
  Checksum: a6324d3005df7dabdd136dd07bafa454b81f3262
   Type: SHA-1
  Checksum: bdbaf67462378210b2520c2e3c39b5509077dc8c70783723a38083cfc5c2536d
   Type: SHA-256