85d91eb5584cab033bb61a85d15f7177  12974_2025_Article_3608.pdf
3c4d5392f88dd4475eb7a745e565f719934621db  12974_2025_Article_3608.pdf
8803193642dbe95d62f969e61bba07d450e318eff043ec1b7657447205772a40  12974_2025_Article_3608.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Tue Nov  4 03:05:34 2025 CET
ModDate:         Tue Nov  4 12:43:23 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           24
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       7388866 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     48  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     46  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     45  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     73  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     49  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes   2013  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     47  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     52  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     55  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     72  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    428  0
MyriadPro-It                         Type 1C           Custom           yes no  yes    431  0
JTAZPG+CambriaMath                   CID TrueType      Identity-H       yes yes yes     96  0
UUNNNK+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    109  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes    128  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-04-28 03:09:14 CEST
 RepresentationInformation: 12974_2025_Article_3608.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-04-27 19:25:17 CEST
  Size: 7388866
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 2071
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: A molecular convergence in the triad of parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Postmortem human brain samples
         Item: 
          Title: Mice
         Item: 
          Title: Mouse model of PD with depressive-like phenotype (DD-PD)
         Item: 
          Title: Corticosterone-induced stress mouse model
         Item: 
          Title: Behavioral analysis
         Item: 
          Title: Gut transit test
         Item: 
          Title: RNA isolation
         Item: 
          Title: First-strand cDNA synthesis
         Item: 
          Title: Analysis of MiRNAs and mRNAs by qPCR
         Item: 
          Title: In Silico MiRNA target gene prediction
         Item: 
          Title: Prediction-based functional pathways and gene ontology analysis
         Item: 
          Title: Immunofluorescence
         Item: 
          Title: Confocal fluorescence microscopy
         Item: 
          Title: Imaris 3D surface rendering
         Item: 
          Title: Statistical analyses
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Identification of common dysregulated MiRNAs linked to IBD in postmortem brains of PD and DD
         Item: 
          Title: Altered inflammatory response markers in postmortem brain samples from patients with PD and DD
         Item: 
          Title: Pathological overexpression of α-Syn in Raphe 5-HT neurons in mice triggers a global glial response, a depressive phenotype and GI dysfunction
         Item: 
          Title: Dysregulation of selected MiRNA expression and inflammatory signaling pathways in the brain areas and ileum in DD-PD mice
         Item: 
          Title: Changes in the expression of selected MiRNAs and inflammatory marker mRNAs in the mPFC and cpu in a mouse model of corticosterone-induced depression
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Limitations and future directions
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Tue Nov 04 03:05:34 CET 2025
    ModDate: Tue Nov 04 12:43:23 CET 2025
   ID: 0x33fbf34ba955e54f9ca9dd535996f0a2, 0x2e648b874a75b7d905480d607e508939
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1904
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1889
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1147
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1953
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1909
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1802
      ImageHeight: 2540
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: JTAZPG+CambriaMath
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -153, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -175, -250, 1007, 933
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: UUNNNK+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: UUNNNK+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: JTAZPG+CambriaMath
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: JTAZPG+CambriaMath
       Flags: Serif, Symbolic
       FontBBox: -1475, -2464, 2868, 3117
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
      xmpMM:InstanceID="uuid:897a4289-737b-4eba-9293-58205b67d3fd"
      xmpMM:OriginalDocumentID="adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31"
      xmpMM:DocumentID="xmp.id:c78945f7-5957-e840-8b2f-99f4ec6bada9"
      xmpMM:RenditionClass="proof:pdf"
      xmpMM:VersionID="1"
      xmp:CreateDate="2025-11-04T03:05:34+01:00"
      xmp:ModifyDate="2025-11-04T12:43:23+01:00"
      xmp:MetadataDate="2025-11-04T12:43:23+01:00"
      xmp:CreatorTool="Adobe InDesign 18.3 (Windows)"
      prism:aggregationType="journal"
      crossmark:DOI="10.1186/s12974-025-03608-y"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1186/s12974-025-03608-y"
      jav:journal_article_version="VoR"
      dc:format="application/pdf"
      pdf:Producer="Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Trapped="False"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <xmpMM:DerivedFrom
        stRef:instanceID="xmp.iid:0a9c117a-70ba-6045-aa43-7147c83c497e"
        stRef:documentID="xmp.did:3e20b67b-651a-2d49-abbe-827f7bf9d73e"
        stRef:renditionClass="default"/>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:parameters="from application/x-indesign to application/pdf"
            stEvt:softwareAgent="Adobe InDesign 18.3 (Windows)"
            stEvt:when="2025-11-04T03:05:35+01:00"/>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:ff549f38-31e6-46b3-8db7-a5035a3f407e"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-11-04T03:53:20+01:00"/>
        </rdf:Seq>
      </xmpMM:History>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="An unordered array of references to resources that were incorporated, by inclusion or reference, into this document."
                  pdfaProperty:name="Ingredients"
                  pdfaProperty:valueType="Bag ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 508, 73, 538, 65
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 65, 279, 57
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 750, 204, 740
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 242, 503, 247, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 252, 503, 257, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 191, 431, 195, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 201, 431, 206, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 151, 299, 156, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 162, 299, 172, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 104, 227, 114, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 278, 179, 288, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 56, 167, 66, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 72, 167, 82, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 95, 143, 104, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 195, 95, 205, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 331, 563, 341, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 347, 563, 356, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 381, 527, 386, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 391, 527, 401, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 407, 527, 417, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 508, 503, 518, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 523, 503, 533, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 459, 395, 469, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 475, 395, 484, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 526, 299, 536, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 304, 287, 314, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 462, 263, 472, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 478, 263, 488, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 427, 239, 436, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 442, 239, 452, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 507, 143, 517, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 523, 143, 533, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 473, 95, 483, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 489, 95, 499, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 365, 71, 375, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 380, 71, 390, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 683, 140, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 144, 683, 154, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 382, 635, 387, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 513, 443, 518, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 526, 335, 536, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 304, 323, 314, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 320, 323, 330, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 244, 539, 254, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 260, 539, 269, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 275, 539, 285, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 134, 275, 144, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 150, 275, 160, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 84, 143, 94, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 99, 143, 109, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 494, 647, 504, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 509, 647, 518, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 433, 95, 442, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 424, 275, 533, 262
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 523, 275, 533, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 331, 179, 340, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 433, 431, 443, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 448, 431, 458, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 480, 419, 490, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 405, 395, 414, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 455, 299, 460, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 327, 251, 332, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 365, 227, 370, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 378, 191, 382, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 412, 143, 417, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 418, 107, 423, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 434, 71, 439, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 209, 695, 214, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 258, 683, 263, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 170, 659, 175, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 129, 575, 134, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 223, 515, 228, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 257, 335, 262, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 95, 191, 100, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 259, 155, 264, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 325, 563, 329, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 326, 491, 331, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 325, 299, 330, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 539, 217, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 100, 503, 105, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 125, 467, 130, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 175, 419, 180, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 234, 407, 239, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 103, 359, 108, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 257, 323, 262, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 145, 311, 150, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 220, 299, 225, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 157, 275, 162, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 75, 263, 80, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 102, 251, 107, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 75, 227, 80, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 201, 227, 206, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 102, 71, 107, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 400, 563, 405, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 508, 527, 513, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 416, 491, 421, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 502, 491, 507, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 398, 467, 403, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 328, 455, 333, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 350, 431, 355, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 374, 371, 379, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 363
      Annotation: 
       Subtype: Link
       Rect: 386, 371, 395, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 478, 335, 483, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 376, 323, 381, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 528, 299, 533, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 347, 287, 352, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 461, 287, 466, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 519, 287, 524, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 444, 107, 453, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 611, 112, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 97, 575, 102, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 239, 575, 249, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 254, 575, 264, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 59, 503, 69, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 75, 503, 85, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 134, 479, 139, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 249, 443, 254, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 56, 335, 61, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 130, 251, 135, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 239, 227, 244, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 232, 155, 237, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 78, 119, 83, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 107, 83, 112, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 458, 587, 463, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 506, 515, 516, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 523, 515, 533, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 304, 467, 309, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 420, 431, 425, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 418, 395, 428, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 445, 167, 450, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 359, 155, 364, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 385, 131, 390, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 359, 107, 364, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 505, 107, 510, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 522, 95, 527, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 180, 515, 185, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 191, 503, 196, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 213, 491, 218, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 113, 419, 118, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 214, 419, 219, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 214, 407, 219, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 243, 395, 248, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 257, 359, 262, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 157, 347, 162, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 274, 335, 279, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 277, 323, 282, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 114, 275, 119, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 221, 275, 226, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 113, 263, 118, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 181, 251, 185, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 77, 227, 81, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 203, 155, 208, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 367, 419, 376, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 390, 383, 394, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 483, 311, 488, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 322, 263, 327, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 430, 263, 435, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 522, 263, 527, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 415, 251, 420, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 373, 215, 377, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 324, 203, 329, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 373, 191, 378, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 325, 107, 330, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 326, 71, 331, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 330, 681, 338, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 16
     Thumb: true
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 126, 419, 136, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 142, 419, 152, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 186, 107, 196, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 202, 107, 211, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 358, 491, 368, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 373, 491, 382, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 387, 491, 397, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 366, 395, 375, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 380, 395, 390, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 455, 311, 465, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 363, 263, 373, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 497, 179, 507, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 343, 119, 353, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
     Thumb: true
    Page: 
     Sequence: 18
     Thumb: true
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 587, 287, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 275, 575, 285, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 133, 491, 142, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 150, 491, 159, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 165, 491, 175, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 59, 407, 69, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 76, 407, 85, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 129, 383, 138, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 122, 239, 132, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 241, 119, 251, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 340, 575, 350, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 523, 491, 533, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 357, 431, 367, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 481, 215, 490, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 525, 167, 535, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 463, 155, 472, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 445, 119, 455, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 365, 691, 373, 681
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 707, 232, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 135, 671, 145, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 151, 671, 160, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 215, 587, 225, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 183, 563, 193, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 199, 563, 208, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 196, 527, 206, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 59, 491, 69, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 228, 491, 238, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 233, 383, 243, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 157, 191, 167, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 172, 191, 182, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 187, 167, 197, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 202, 167, 212, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 342, 671, 352, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 358, 671, 368, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 468, 647, 477, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 483, 647, 493, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 323, 551, 333, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 307, 479, 317, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 502, 335, 512, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 518, 335, 533, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 379, 275, 394, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 400, 275, 414, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 394, 239, 408, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 377
      Annotation: 
       Subtype: Link
       Rect: 391, 107, 401, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 410, 107, 420, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 429, 107, 438, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
     Thumb: true
    Page: 
     Sequence: 21
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 443, 197, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 168, 251, 178, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 373
      Annotation: 
       Subtype: Link
       Rect: 280, 83, 285, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 496, 287, 535, 278
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 278, 397, 269
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 22
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 306, 252, 297
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 280, 279, 288, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 270, 167, 261
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 23
     Thumb: true
    Page: 
     Sequence: 24
     Thumb: true
  Checksum: bd8bf5d6
   Type: CRC32
  Checksum: 85d91eb5584cab033bb61a85d15f7177
   Type: MD5
  Checksum: 3c4d5392f88dd4475eb7a745e565f719934621db
   Type: SHA-1
  Checksum: 8803193642dbe95d62f969e61bba07d450e318eff043ec1b7657447205772a40
   Type: SHA-256