99f50dc7254b3fc184d3a0d34211f869 Dose_escalation_study.pdf 7972824d55cee9badbce47aace71f01c5280318d Dose_escalation_study.pdf 19b000f12fd2ce2cd9bf1e95607d09c8a50d27cce14715de309fff30eeccaaa0 Dose_escalation_study.pdf Title: Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia Subject: BLOOD NEOPLASIA, 2 (2025) 100110. doi:10.1016/j.bneo.2025.100110 Author: Martin Hutchings∗ Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jul 24 13:19:01 2025 CEST ModDate: Thu Jul 24 13:21:15 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 2784381 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- INCJEF+AdvTT51434264 Type 1C WinAnsi 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IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Study design and patient eligibility Destination: slink1 Item: Title: End points Destination: slink2 Item: Title: Statistical analysis Destination: slink3 Item: Title: Results Destination: flink3 Children: Item: Title: Patients Destination: slink4 Item: Title: Safety and tolerability Destination: slink5 Item: Title: Efficacy Destination: slink6 Item: Title: PK and exposure-response analysis Destination: slink7 Item: Title: Immunogenicity Destination: slink8 Item: Title: Pharmacodynamics and molecular correlates of response Destination: slink9 Item: Title: Discussion Destination: flink4 Item: Title: Authorship 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Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: INCJEF+AdvTT51434264 FontSubset: true FirstChar: 35 LastChar: 122 FontDescriptor: FontName: INCJEF+AdvTT51434264 Flags: Serif, Nonsymbolic FontBBox: -10, -239, 1031, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: INCKBO+AdvOT702dc698.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: INCKBO+AdvOT702dc698.I Flags: Nonsymbolic FontBBox: -93, -250, 1104, 947 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.bneo.2025.100110 Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia Martin Hutchings∗ Koorosh Korfi∗ Pau Montesinos Armando Santoro Hsin-An Hou Pilar Martinez-Sanchez Susana Vives Sara Galimberti Tsai-Yun Chen Marco Frigeni Sylvain Garciaz Olga Salamero Garcia Su-Peng Yeh Karen Yee Jordi Esteve Ashish Bajel Shaun Fleming Anne Catherine Bretz Jan Attig Min Sun Sina Nassiri Tobias Rutishauser Christian Klein Y. May Ma Gabriel Schnetzler Stephanie Vauleon Huixin Yu Teresa Barata Muriel Richard Silke Simon Heather Hinton Nino Keshelava Marion Subklewe BLOOD NEOPLASIA, 2 (2025) 100110. doi:10.1016/j.bneo.2025.100110 The American Society of Hematology journal BLOOD NEOPLASIA © 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. 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