47d74f3d7624818b89833f6ff61cb4b8 jjaf132.pdf 9fc5ad92c7203ae807ab48a11483eac886efdbd7 jjaf132.pdf c78c5af3465aff37d4dbae67a91ded74cefa4ea9df3ba2605d797871a37be27b jjaf132.pdf Title: Patient-reported outcome measures poorly correlate with objective inflammatory bowel disease activity measures: a systematic review Subject: Doi: 10.1093/ecco-jcc/jjaf132 Journal of Crohn’s and Colitis, 19, 9, 2025 Publication Date: 08/08/2025 Abstract Background and Aims We investigated the correlations between patient-reported outcome measures (PROMs) and other measures of inflammatory bowel disease (IBD) activity.Methods A systematic literature review was performed up to June 2022. Searches were conducted in PubMed, Scopus, and Web of Science. A descriptive analysis was performed. The search protocol was registered in PROSPERO (CRD42022383899).Results Nineteen studies assessed correlations between PROMs and clinical, endoscopic, and laboratory measures of disease activity in IBD. In Crohn’s disease (CD), weak positive correlations were reported for PROMs (eg, the 2 item patient-reported outcome [PRO-2], mobile Health Index [mHI] for CD) and endoscopic scores, more often the Simple Endoscopic Score for CD (SES-CD). In ulcerative colitis (UC), PROMs like PRO-2, the Monitor IBD at Home rectal bleeding item, and the mHI showed weak-to-moderate correlations with the Mayo endoscopic subscore (MES). PROMs also demonstrated limited concordance with laboratory measures such as fecal calprotectin (FCP) and C-reactive protein (CRP) in both CD and UC. The substantial heterogeneity in study designs precluded a structured analysis.Conclusions Although current PROMs offer valuable complementary insights into IBD control from the patient’s perspective, they cannot replace objective measures of IBD activity. Future research should focus on refining PROMs and generating composite indices to improve their accuracy and usefulness. Keywords: PROM; Crohn’s disease; ulcerative colitis Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Tue Oct 21 14:44:38 2025 CEST ModDate: Tue Oct 21 14:45:47 2025 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1787242 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BBOCFG+UniversLTStd-CnObl Type 1C WinAnsi yes yes yes 2367 0 ACZWRI+UniversLTStd-Cn Type 1C Custom yes yes yes 2368 0 YZAKPM+UniversLTStd-Bold Type 1C Custom yes yes yes 2369 0 WWBYNQ+UniversLTStd-BoldCn Type 1C WinAnsi yes yes yes 2370 0 UTXMLU+UniversLTStd-Light Type 1C Custom yes yes yes 2381 0 TPNGXW+SabonLTPro-Roman Type 1C Custom yes yes yes 2386 0 RHWSUA+MyriadPro-Semibold Type 1C WinAnsi yes yes no 2418 0 PCFTTE+UniversLTStd Type 1C WinAnsi yes yes yes 327 0 NZGHRI+UniversLTStd-Obl Type 1C WinAnsi yes yes yes 323 0 MVRBDK+SabonLTPro-Italic Type 1C Custom yes yes yes 331 0 NSWXRI+SabonLTPro-Bold Type 1C Custom yes yes yes 340 0 GAGCXW+SabonLTPro-BoldItalic Type 1C WinAnsi yes yes yes 336 0 ZNUMDK+STIX-Regular Type 1C Custom yes yes yes 346 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-09 04:19:54 CEST RepresentationInformation: jjaf132.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-05-08 16:24:53 CEST Size: 1787242 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Annotation object is not a dictionary ID: PDF-HUL-114 Offset: 7966 MIMEtype: application/pdf PDFMetadata: Objects: 2428 FreeObjects: 1941 IncrementalUpdates: 3 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseNone Language: en-US Outlines: Item: Title: Active Content List Children: Item: Title: 1. Introduction Item: Title: 2. Materials and methods Item: Title: 3. Results Item: Title: 4. Discussion Item: Title: Author contributions Item: Title: Supplementary material Item: Title: Funding Item: Title: Conflicts of interest Item: Title: Data availability Info: Title: Patient-reported outcome measures poorly correlate with objective inflammatory bowel disease activity measures: a systematic review Subject: Doi: 10.1093/ecco-jcc/jjaf132 Journal of Crohn’s and Colitis, 19, 9, 2025 Publication Date: 08/08/2025 Abstract Background and Aims We investigated the correlations between patient-reported outcome measures (PROMs) and other measures of inflammatory bowel disease (IBD) activity.Methods A systematic literature review was performed up to June 2022. Searches were conducted in PubMed, Scopus, and Web of Science. A descriptive analysis was performed. The search protocol was registered in PROSPERO (CRD42022383899).Results Nineteen studies assessed correlations between PROMs and clinical, endoscopic, and laboratory measures of disease activity in IBD. In Crohn’s disease (CD), weak positive correlations were reported for PROMs (eg, the 2 item patient-reported outcome [PRO-2], mobile Health Index [mHI] for CD) and endoscopic scores, more often the Simple Endoscopic Score for CD (SES-CD). In ulcerative colitis (UC), PROMs like PRO-2, the Monitor IBD at Home rectal bleeding item, and the mHI showed weak-to-moderate correlations with the Mayo endoscopic subscore (MES). PROMs also demonstrated limited concordance with laboratory measures such as fecal calprotectin (FCP) and C-reactive protein (CRP) in both CD and UC. The substantial heterogeneity in study designs precluded a structured analysis.Conclusions Although current PROMs offer valuable complementary insights into IBD control from the patient’s perspective, they cannot replace objective measures of IBD activity. Future research should focus on refining PROMs and generating composite indices to improve their accuracy and usefulness. 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-172, -270, 1064, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2025-10-21T18:14:38+05:30 2025-10-21T18:15:47+05:30 2025-10-21T18:15:47+05:30 Adobe InDesign 19.5 (Windows) uuid:992458e4-d4cc-2eae-5e43-e44c80378182 xmp.did:cef66db3-2f7a-6c40-968a-71621d843ea4 xmp.id:1dfae8fc-ae7c-654c-a27d-4b3b2a9d3d7b proof:pdf xmp.iid:ac1c9402-1fbe-2e41-91cf-ecd8c57a18ff xmp.did:efa209a6-1886-7a45-947f-145f29fc14a9 xmp.did:cef66db3-2f7a-6c40-968a-71621d843ea4 default converted from application/x-indesign to application/pdf Adobe InDesign 19.5 (Windows) / 2025-10-21T18:14:38+05:30 application/pdf Patient-reported outcome measures poorly correlate with objective inflammatory bowel disease activity measures: a systematic review Xavier Calvet Maria Giovanna Ferrario Vanessa Marfil Santos Armenteros Manuel Barreiro-de Acosta Doi: 10.1093/ecco-jcc/jjaf132 Journal of Crohn’s and Colitis, 19, 9, 2025 Publication Date: 08/08/2025 Abstract Background and Aims We investigated the correlations between patient-reported outcome measures (PROMs) and other measures of inflammatory bowel disease (IBD) activity.Methods A systematic literature review was performed up to June 2022. Searches were conducted in PubMed, Scopus, and Web of Science. A descriptive analysis was performed. The search protocol was registered in PROSPERO (CRD42022383899).Results Nineteen studies assessed correlations between PROMs and clinical, endoscopic, and laboratory measures of disease activity in IBD. In Crohn’s disease (CD), weak positive correlations were reported for PROMs (eg, the 2 item patient-reported outcome [PRO-2], mobile Health Index [mHI] for CD) and endoscopic scores, more often the Simple Endoscopic Score for CD (SES-CD). In ulcerative colitis (UC), PROMs like PRO-2, the Monitor IBD at Home rectal bleeding item, and the mHI showed weak-to-moderate correlations with the Mayo endoscopic subscore (MES). PROMs also demonstrated limited concordance with laboratory measures such as fecal calprotectin (FCP) and C-reactive protein (CRP) in both CD and UC. The substantial heterogeneity in study designs precluded a structured analysis.Conclusions Although current PROMs offer valuable complementary insights into IBD control from the patient’s perspective, they cannot replace objective measures of IBD activity. Future research should focus on refining PROMs and generating composite indices to improve their accuracy and usefulness. © The Author(s) 2025. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. 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