14e244b47803f4fa1c3c3ee9efbb924f 328084.pdf e690ff4f478a4e9966df17207e39a32007cd4740 328084.pdf 6fd1224b7f52bf35c5bf01f69dd80f99bc42a1ce7a995b0e71a7627975009bda 328084.pdf Title: Effect of STW 5‐II (Iberogast‐N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO‐2 Study Subject: Neurogastroenterology Motil 2025.37:e70123 Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Sat Oct 11 06:32:22 2025 CEST ModDate: Mon May 4 12:34:19 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 504409 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JIQAGF+STIXTwoText Type 1C Custom yes yes yes 35 0 TRZJLL+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 38 0 TSMIQL+STIXTwoText-Italic Type 1C WinAnsi yes yes yes 37 0 TEDVLL+ArialRoundedMTBold Type 1C WinAnsi yes yes no 217 0 VNTLNH+STIXTwoText-Bold Type 1C Custom yes yes yes 36 0 SFTPXN+STIX-Regular Type 1C Custom yes yes yes 39 0 Times-Roman Type 1 WinAnsi no no no 5 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-05 04:08:24 CEST RepresentationInformation: 328084.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-05-04 13:22:41 CEST Size: 504409 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study Children: Item: Title: ABSTRACT Item: Title: 1   |   Introduction Item: Title: 2   |   Materials and Methods Children: Item: Title: 2.1   |   Study Participants Item: Title: 2.2   |   Gas Transit Test Children: Item: Title: 2.2.1   |   Gastric Gas Infusion Item: Title: 2.2.2   |   Nutrients Infusion Item: Title: 2.2.3   |   Measurement of Rectal Gas Evacuation Item: Title: 2.2.4   |   Measurement of Gastric Belching Item: Title: 2.3   |   Perception Measurements Item: Title: 2.4   |   Measurements of Abdominal Distension Item: Title: 2.5   |   Procedure Item: Title: 2.6   |   Experimental Design Item: Title: 2.7   |   Data Analysis Item: Title: 2.8   |   Statistical Analysis Item: Title: 3   |   Results Children: Item: Title: 3.1   |   General Aspects Item: Title: 3.2   |   Effect of STW 5-II on Gas Transit During the Gas Challenge Test Item: Title: 3.3   |   Effect of STW 5-II on Belches During the Gas Challenge Test Item: Title: 3.4   |   Effect of STW 5-II on Abdominal Symptoms During the Challenge Test Item: Title: 3.5   |   Effect of STW 5-II on Objective Abdominal Distension During the Gas Challenge Test Item: Title: 4   |   Discussion Item: Title: Author Contributions Item: Title: Acknowledgments Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 995 ImageHeight: 954 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 996 ImageHeight: 1721 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 995 ImageHeight: 1425 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: JIQAGF+STIXTwoText FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: JIQAGF+STIXTwoText Flags: Serif, Nonsymbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VNTLNH+STIXTwoText-Bold FontSubset: true FirstChar: 29 LastChar: 124 FontDescriptor: FontName: VNTLNH+STIXTwoText-Bold Flags: Serif, Nonsymbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TSMIQL+STIXTwoText-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TSMIQL+STIXTwoText-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -362, 1298, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TRZJLL+STIXTwoText-BoldItalic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TRZJLL+STIXTwoText-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SFTPXN+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: SFTPXN+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TEDVLL+ArialRoundedMTBold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: TEDVLL+ArialRoundedMTBold Flags: Nonsymbolic FontBBox: -174, -211, 1185, 946 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1111/nmo.70123 10.1111/nmo.70123https://doi.org/10.1111/nmo.70123 2025-07-20trueonlinelibrary.wiley.com10.1111/nmo.70123 onlinelibrary.wiley.comtrue10.1111/nmo.701232025-07-20 VoR Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 45, 25, 155, 14 Annotation: Subtype: Link Rect: 158, 672, 213, 656 Annotation: Subtype: Link Rect: 109, 582, 122, 569 ActionDest: 146 Annotation: Subtype: Link Rect: 216, 582, 219, 569 ActionDest: 146 Annotation: Subtype: Link Rect: 288, 582, 296, 569 ActionDest: 146 Annotation: Subtype: Link Rect: 357, 582, 365, 569 ActionDest: 146 Annotation: Subtype: Link Rect: 365, 583, 378, 571 Annotation: Subtype: Link Rect: 438, 582, 446, 569 ActionDest: 146 Annotation: Subtype: Link Rect: 125, 571, 133, 558 ActionDest: 146 Annotation: Subtype: Link Rect: 133, 572, 146, 560 Annotation: Subtype: Link Rect: 199, 571, 199, 558 Annotation: Subtype: Link Rect: 199, 571, 207, 558 ActionDest: 146 Annotation: Subtype: Link Rect: 207, 572, 219, 560 Annotation: Subtype: Link Rect: 147, 519, 247, 508 Annotation: Subtype: Link Rect: 489, 188, 503, 175 ActionDest: 126 Annotation: Subtype: Link Rect: 202, 78, 297, 68 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 122, 505, 135, 492 ActionDest: 126 Annotation: Subtype: Link Rect: 48, 459, 62, 446 ActionDest: 126 Annotation: Subtype: Link Rect: 122, 413, 126, 400 ActionDest: 126 Annotation: Subtype: Link Rect: 166, 390, 170, 377 ActionDest: 126 Annotation: Subtype: Link Rect: 89, 333, 106, 320 ActionDest: 126 Annotation: Subtype: Link Rect: 123, 310, 127, 297 ActionDest: 126 Annotation: Subtype: Link Rect: 105, 206, 113, 193 ActionDest: 144 Annotation: Subtype: Link Rect: 205, 183, 228, 170 ActionDest: 144 Annotation: Subtype: Link Rect: 88, 172, 96, 159 ActionDest: 144 Annotation: Subtype: Link Rect: 187, 172, 195, 159 ActionDest: 144 Annotation: Subtype: Link Rect: 261, 68, 277, 55 ActionDest: 126 Annotation: Subtype: Link Rect: 501, 509, 506, 496 ActionDest: 30 Annotation: Subtype: Link Rect: 505, 452, 513, 439 ActionDest: 144 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 113, 245, 151, 232 ActionDest: 144 Annotation: Subtype: Link Rect: 417, 740, 468, 727 ActionDest: 144 Annotation: Subtype: Link Rect: 353, 613, 362, 600 ActionDest: 144 Annotation: Subtype: Link Rect: 355, 543, 367, 531 ActionDest: 72 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 60, 429, 95, 417 ActionDest: 144 Annotation: Subtype: Link Rect: 145, 280, 176, 267 ActionDest: 126 Annotation: Subtype: Link Rect: 188, 176, 206, 164 ActionDest: 126 Annotation: Subtype: Link Rect: 479, 487, 483, 474 ActionDest: 82 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 279, 728, 283, 716 ActionDest: 94 Annotation: Subtype: Link Rect: 75, 280, 79, 267 ActionDest: 94 Annotation: Subtype: Link Rect: 214, 234, 218, 221 ActionDest: 94 Annotation: Subtype: Link Rect: 149, 96, 153, 83 ActionDest: 110 Annotation: Subtype: Link Rect: 360, 256, 364, 244 ActionDest: 110 Annotation: Subtype: Link Rect: 457, 118, 462, 105 ActionDest: 94 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 227, 130, 236, 117 ActionDest: 144 Annotation: Subtype: Link Rect: 115, 61, 120, 48 ActionDest: 126 Annotation: Subtype: Link Rect: 308, 349, 317, 336 ActionDest: 144 Annotation: Subtype: Link Rect: 341, 314, 350, 302 ActionDest: 144 Annotation: Subtype: Link Rect: 419, 245, 428, 233 ActionDest: 144 Annotation: Subtype: Link Rect: 432, 61, 440, 49 ActionDest: 144 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 238, 590, 260, 578 ActionDest: 144 Annotation: Subtype: Link Rect: 202, 567, 210, 555 ActionDest: 144 Annotation: Subtype: Link Rect: 235, 418, 258, 405 ActionDest: 144 Annotation: Subtype: Link Rect: 148, 383, 156, 371 ActionDest: 144 Annotation: Subtype: Link Rect: 248, 372, 257, 359 ActionDest: 144 Annotation: Subtype: Link Rect: 75, 314, 106, 302 ActionDest: 126 Annotation: Subtype: Link Rect: 258, 188, 267, 175 ActionDest: 144 Annotation: Subtype: Link Rect: 242, 176, 250, 164 ActionDest: 144 Page: Sequence: 8 Checksum: 188b3829 Type: CRC32 Checksum: 14e244b47803f4fa1c3c3ee9efbb924f Type: MD5 Checksum: e690ff4f478a4e9966df17207e39a32007cd4740 Type: SHA-1 Checksum: 6fd1224b7f52bf35c5bf01f69dd80f99bc42a1ce7a995b0e71a7627975009bda Type: SHA-256