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Title:           Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome
Subject:         DOI: 10.1093/brain/awaf102; Brain, 148, 11, 2025-03-17.; Abstract: Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside antibodies are thought to play a key role in the clinical diversity of the disease and can be helpful in clinical practice. Extensive research into clinical associations of individual anti-ganglioside antibody specificities has been performed. Recent research has highlighted glycolipid complexes, glycolipid combinations that may alter antibody binding, as targets. In this study, we investigated antibody reactivity patterns to glycolipids and glycolipid complexes using combinatorial array, in relation to clinical features in Guillain-Barré syndrome.In total, 1413 patients from the observational International Guillain-Barré syndrome Outcome Study (0–91 years, 60.3% male) and 1061 controls (healthy, family, infe
Keywords:        peripheral neuropathy; autoantibody
Author:          Robin C. M. Thomma
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     Item: 
      Title: Large-scale profiling of antibody reactivity to
glycolipids in patients with Guillain-Barré
syndrome
     Item: 
      Title: Introduction
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     Item: 
      Title: Materials and methods
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        Title: Study population
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       Item: 
        Title: Antibody testing in glyco-array
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       Item: 
        Title: Statistical analyses
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         Item: 
          Title: Comparative analyses
          Destination: secawaf102-s2.3.1
         Item: 
          Title: Assessment of the diagnostic value
          Destination: secawaf102-s2.3.2
         Item: 
          Title: Clustering and heat map generation
          Destination: secawaf102-s2.3.3
         Item: 
          Title: Associations of complex interactions with electrophysiological subtypes
          Destination: secawaf102-s2.3.4
         Item: 
          Title: Assessment of prognostic value
          Destination: secawaf102-s2.3.5
         Item: 
          Title: Data processing and software
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     Item: 
      Title: Results
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      Children: 
       Item: 
        Title: Anti-glycolipid (complex) antibodies discriminate patients from controls
        Destination: secawaf102-s3.1
       Item: 
        Title: Associations of anti-glycolipid (complex) antibodies with preceding infections and clinical features
        Destination: secawaf102-s3.2
       Item: 
        Title: Cluster analysis of anti-glycolipid (complex) antibodies and clinical associations of clusters
        Destination: secawaf102-s3.3
       Item: 
        Title: Distinction of electrophysiological subtypes based on anti-glycolipid (complex) antibodies
        Destination: secawaf102-s3.4
       Item: 
        Title: Prognostic value of anti-glycolipid (complex) antibodies
        Destination: secawaf102-s3.5
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      Title: Discussion
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     Item: 
      Title: Data availability
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      Title: Acknowledgements
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      Title: Funding
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     Item: 
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        Title: Members of the IGOS consortium
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  Checksum: 21fc91dd
   Type: CRC32
  Checksum: 64a1fa59faad598ad325cdfc20632cd9
   Type: MD5
  Checksum: e68e1f30df7b10f7d091baddbb3554294d7fbedb
   Type: SHA-1
  Checksum: 66b6720d2b820355a831f69182ab07b94f95e14b962729a811bdf9a6dc9752d7
   Type: SHA-256