050a2bb1adef0b6f0929317bee869a75 ENE-32-e70227.pdf bd93dbc4446e38d78be1221c2a8d84d860618ac9 ENE-32-e70227.pdf aaffe626dccd33072315c4fa58177d5c30f2f04b0fbf9f830e28f11cd5ba8c90 ENE-32-e70227.pdf Title: The Variant rs7665090 Is Associated With Interferon‐Beta Response in Multiple Sclerosis Patients Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Wed Jul 16 03:18:27 2025 CEST ModDate: Wed Jul 16 03:18:29 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 573855 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SDSXWT+STIXTwoText Type 1C Custom yes yes yes 338 0 MCOIQF+STIXTwoText-Italic Type 1C WinAnsi yes yes yes 339 0 QVPGUX+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 340 0 ASNJED+STIXTwoText-Bold Type 1C Custom yes yes yes 341 0 AALJED+ArialRoundedMTBold Type 1C WinAnsi yes yes no 275 0 ZBBDQF+STIX-Regular Type 1C Custom yes yes yes 22 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-23 04:22:05 CEST RepresentationInformation: ENE-32-e70227.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-05-22 14:46:05 CEST Size: 573855 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 356 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: The Variant rs7665090 Is Associated With Interferon-Beta Response in Multiple Sclerosis Patients Children: Item: Title: ABSTRACT Item: Title: 〱   ぼ   ぉのぴひはつふっぴどはの Item: Title: 〲   ぼ   きちぴづひどちぬび〠ちのつ〠きづぴとはつび Children: Item: Title: 〲〮〱   ぼ   ぐちぴどづのぴび〠ちのつ〠ぃひどぴづひどち〠はて〠ごひづちぴねづのぴ〠げづびばはのびづ Item: Title: 〲〮〲   ぼ   ぇづのはぴべばどので Item: Title: 〲〮〳   ぼ   こぴちぴどびぴどっちぬ〠ぁのちぬべびどび Item: Title: 〲〮〴   ぼ   ぅぴとどっちぬ〠ぉびびふづび Item: Title: 〳   ぼ   げづびふぬぴび Children: Item: Title: 〳〮〱   ぼ   ひび〷〶〶〵〰〹〰〠ぐはぬべねはひばとどびね Item: Title: 〳〮〲   ぼ   ぁびびはっどちぴどはの〠あづぴぷづづの〠ぴとづ〠ひび〷〶〶〵〰〹〰〠ざちひどちのぴ〠ちのつ〠ぴとづ〠げづびばはのびづ〠ぴは〠ごとづひちばどづび Item: Title: 〴   ぼ   いどびっふびびどはの Item: Title: Author Contributions Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Info: Title: The Variant rs7665090 Is Associated With Interferon‐Beta Response in Multiple Sclerosis Patients Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Wed Jul 16 03:48:27 CEST 2025 ModDate: Wed Jul 16 03:48:29 CEST 2025 ID: 0x7012562b9fd07741872cb06fec8eb29a, 0xe474603ed506d674ef49d27aca6ef74e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1997 ImageHeight: 2269 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1473 ImageHeight: 1823 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: SDSXWT+STIXTwoText FontSubset: true FirstChar: 25 LastChar: 252 FontDescriptor: FontName: SDSXWT+STIXTwoText Flags: Serif, Nonsymbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AALJED+ArialRoundedMTBold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: AALJED+ArialRoundedMTBold Flags: Nonsymbolic FontBBox: -174, -211, 1185, 946 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MCOIQF+STIXTwoText-Italic FontSubset: true FirstChar: 32 LastChar: 233 FontDescriptor: FontName: MCOIQF+STIXTwoText-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -362, 1298, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: QVPGUX+STIXTwoText-BoldItalic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: QVPGUX+STIXTwoText-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ASNJED+STIXTwoText-Bold FontSubset: true FirstChar: 30 LastChar: 243 FontDescriptor: FontName: ASNJED+STIXTwoText-Bold Flags: Serif, Nonsymbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZBBDQF+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: ZBBDQF+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: VoR 10.1111/ene.70227 10.1111/ene.70227 10.1111/(ISSN)1468-1331 3 The Variant rs7665090 Is Associated With Interferon‐Beta Response in Multiple Sclerosis Patients Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 45, 26, 145, 16 Annotation: Subtype: Link Rect: 158, 672, 213, 656 Annotation: Subtype: Link Rect: 109, 582, 112, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 112, 583, 125, 571 Annotation: Subtype: Link Rect: 190, 582, 193, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 267, 582, 270, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 338, 582, 341, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 421, 582, 424, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 519, 582, 522, 569 ActionDest: 227 Annotation: Subtype: Link Rect: 522, 583, 535, 571 Annotation: Subtype: Link Rect: 111, 571, 115, 558 ActionDest: 227 Annotation: Subtype: Link Rect: 180, 571, 183, 558 ActionDest: 227 Annotation: Subtype: Link Rect: 274, 571, 277, 558 ActionDest: 227 Annotation: Subtype: Link Rect: 384, 571, 387, 558 ActionDest: 227 Annotation: Subtype: Link Rect: 482, 571, 485, 558 ActionDest: 227 Annotation: Subtype: Link Rect: 119, 560, 122, 547 ActionDest: 227 Annotation: Subtype: Link Rect: 214, 560, 217, 547 ActionDest: 227 Annotation: Subtype: Link Rect: 338, 560, 341, 547 ActionDest: 227 Annotation: Subtype: Link Rect: 400, 560, 403, 547 ActionDest: 227 Annotation: Subtype: Link Rect: 512, 560, 516, 547 ActionDest: 227 Annotation: Subtype: Link Rect: 97, 549, 100, 536 ActionDest: 227 Annotation: Subtype: Link Rect: 173, 549, 176, 536 ActionDest: 227 Annotation: Subtype: Link Rect: 236, 549, 239, 536 ActionDest: 227 Annotation: Subtype: Link Rect: 239, 550, 252, 538 Annotation: Subtype: Link Rect: 331, 549, 334, 536 ActionDest: 227 Annotation: Subtype: Link Rect: 334, 550, 346, 538 Annotation: Subtype: Link Rect: 417, 549, 421, 536 ActionDest: 227 Annotation: Subtype: Link Rect: 128, 538, 131, 525 ActionDest: 227 Annotation: Subtype: Link Rect: 131, 539, 144, 527 Annotation: Subtype: Link Rect: 202, 538, 205, 525 ActionDest: 227 Annotation: Subtype: Link Rect: 250, 538, 258, 525 ActionDest: 227 Annotation: Subtype: Link Rect: 258, 539, 271, 527 Annotation: Subtype: Link Rect: 351, 538, 359, 525 ActionDest: 227 Annotation: Subtype: Link Rect: 443, 538, 443, 525 Annotation: Subtype: Link Rect: 443, 538, 451, 525 ActionDest: 227 Annotation: Subtype: Link Rect: 451, 539, 464, 527 Annotation: Subtype: Link Rect: 172, 475, 265, 464 Annotation: Subtype: Link Rect: 443, 161, 447, 148 ActionDest: 110 Annotation: Subtype: Link Rect: 202, 78, 349, 68 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 136, 728, 140, 716 ActionDest: 110 Annotation: Subtype: Link Rect: 79, 705, 83, 693 ActionDest: 110 Annotation: Subtype: Link Rect: 175, 648, 179, 635 ActionDest: 110 Annotation: Subtype: Link Rect: 108, 602, 112, 589 ActionDest: 110 Annotation: Subtype: Link Rect: 231, 556, 235, 543 ActionDest: 110 Annotation: Subtype: Link Rect: 184, 533, 188, 520 ActionDest: 110 Annotation: Subtype: Link Rect: 77, 475, 81, 463 ActionDest: 110 Annotation: Subtype: Link Rect: 91, 337, 106, 325 ActionDest: 110 Annotation: Subtype: Link Rect: 145, 291, 150, 279 ActionDest: 110 Annotation: Subtype: Link Rect: 150, 257, 159, 244 ActionDest: 110 Annotation: Subtype: Link Rect: 68, 211, 72, 198 ActionDest: 110 Annotation: Subtype: Link Rect: 216, 188, 224, 175 ActionDest: 110 Annotation: Subtype: Link Rect: 80, 153, 84, 141 ActionDest: 110 Annotation: Subtype: Link Rect: 190, 107, 194, 95 ActionDest: 110 Annotation: Subtype: Link Rect: 103, 73, 112, 60 ActionDest: 110 Annotation: Subtype: Link Rect: 441, 648, 450, 635 ActionDest: 110 Annotation: Subtype: Link Rect: 517, 556, 526, 543 ActionDest: 110 Annotation: Subtype: Link Rect: 467, 406, 475, 394 ActionDest: 110 Annotation: Subtype: Link Rect: 536, 61, 544, 49 ActionDest: 110 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 48, 130, 185, 118 Annotation: Subtype: Link Rect: 76, 119, 80, 106 ActionDest: 74 Annotation: Subtype: Link Rect: 225, 96, 233, 83 ActionDest: 110 Annotation: Subtype: Link Rect: 382, 671, 387, 658 ActionDest: 80 Annotation: Subtype: Link Rect: 333, 556, 337, 543 ActionDest: 94 Annotation: Subtype: Link Rect: 414, 498, 418, 486 ActionDest: 80 Annotation: Subtype: Link Rect: 331, 475, 336, 463 ActionDest: 94 Annotation: Subtype: Link Rect: 423, 429, 428, 417 ActionDest: 94 Annotation: Subtype: Link Rect: 543, 314, 547, 302 ActionDest: 94 Annotation: Subtype: Link Rect: 334, 303, 338, 290 ActionDest: 104 Annotation: Subtype: Link Rect: 543, 222, 547, 210 ActionDest: 94 Annotation: Subtype: Link Rect: 334, 211, 338, 198 ActionDest: 104 Annotation: Subtype: Link Rect: 518, 119, 527, 106 ActionDest: 110 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 380, 61, 389, 48 ActionDest: 110 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 62, 245, 71, 232 ActionDest: 110 Annotation: Subtype: Link Rect: 65, 210, 74, 197 ActionDest: 110 Annotation: Subtype: Link Rect: 175, 153, 184, 140 ActionDest: 110 Annotation: Subtype: Link Rect: 187, 118, 196, 105 ActionDest: 110 Annotation: Subtype: Link Rect: 332, 256, 340, 243 ActionDest: 110 Annotation: Subtype: Link Rect: 484, 187, 493, 174 ActionDest: 110 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 98, 328, 107, 315 ActionDest: 110 Annotation: Subtype: Link Rect: 88, 248, 97, 235 ActionDest: 110 Annotation: Subtype: Link Rect: 252, 202, 276, 189 ActionDest: 110 Annotation: Subtype: Link Rect: 480, 733, 484, 720 ActionDest: 94 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 436, 294, 440, 283 ActionDest: 94 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 203, 652, 289, 641 Annotation: Subtype: Link Rect: 45, 642, 105, 631 Annotation: Subtype: Link Rect: 45, 607, 211, 596 Annotation: Subtype: Link Rect: 187, 582, 289, 571 Annotation: Subtype: Link Rect: 45, 572, 94, 561 Annotation: Subtype: Link Rect: 208, 547, 289, 536 Annotation: Subtype: Link Rect: 45, 537, 115, 526 Annotation: Subtype: Link Rect: 237, 512, 289, 501 Annotation: Subtype: Link Rect: 45, 502, 140, 491 Annotation: Subtype: Link Rect: 251, 467, 289, 456 Annotation: Subtype: Link Rect: 45, 457, 177, 446 Annotation: Subtype: Link Rect: 251, 422, 289, 411 Annotation: Subtype: Link Rect: 45, 412, 115, 401 Annotation: Subtype: Link Rect: 251, 377, 289, 366 Annotation: Subtype: Link Rect: 45, 367, 143, 356 Annotation: Subtype: Link Rect: 45, 322, 193, 311 Annotation: Subtype: Link Rect: 86, 267, 232, 256 Annotation: Subtype: Link Rect: 119, 232, 254, 221 Annotation: Subtype: Link Rect: 177, 197, 289, 186 Annotation: Subtype: Link Rect: 45, 187, 84, 176 Annotation: Subtype: Link Rect: 168, 117, 289, 106 Annotation: Subtype: Link Rect: 45, 107, 69, 96 Annotation: Subtype: Link Rect: 103, 72, 262, 61 Annotation: Subtype: Link Rect: 306, 721, 435, 710 Annotation: Subtype: Link Rect: 424, 686, 549, 675 Annotation: Subtype: Link Rect: 306, 676, 346, 665 Annotation: Subtype: Link Rect: 464, 596, 549, 585 Annotation: Subtype: Link Rect: 306, 586, 380, 575 Annotation: Subtype: Link Rect: 447, 551, 549, 540 Annotation: Subtype: Link Rect: 306, 541, 345, 530 Annotation: Subtype: Link Rect: 306, 496, 445, 485 Annotation: Subtype: Link Rect: 306, 441, 437, 430 Annotation: Subtype: Link Rect: 322, 406, 472, 395 Annotation: Subtype: Link Rect: 497, 361, 549, 350 Annotation: Subtype: Link Rect: 306, 351, 402, 340 Annotation: Subtype: Link Rect: 392, 306, 544, 295 Checksum: de9e0b5b Type: CRC32 Checksum: 050a2bb1adef0b6f0929317bee869a75 Type: MD5 Checksum: bd93dbc4446e38d78be1221c2a8d84d860618ac9 Type: SHA-1 Checksum: aaffe626dccd33072315c4fa58177d5c30f2f04b0fbf9f830e28f11cd5ba8c90 Type: SHA-256