a5e8296e8fd12104d4888fd63f995982 fimmu-15-1445553_1.pdf c508c8486a57047f69ae27285e8add2cce5fcc82 fimmu-15-1445553_1.pdf aa845a961616d585c1e96814763b6bdba157f27da0422a3a334fb77486d6d6ad fimmu-15-1445553_1.pdf Keywords: ELISPOT, infection risk, immunocompromised, pre-transplant, serology, CMV cell-mediated immunity, humoral immune response Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 698305 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FAFNOH+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 573 0 FAFNOI+AdvPSA18C Type 1C WinAnsi yes yes no 574 0 FAFNOJ+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 575 0 FAFNOK+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 576 0 FAFNOL+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 577 0 FAFNOM+AdvPSA323 Type 1C WinAnsi yes yes no 583 0 FAFNON+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 584 0 FAFNOO+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 585 0 FAGBMH+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 593 0 FAGBOH+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 595 0 FAGCCI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 200 0 FAGCCJ+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 208 0 FAGCCH+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 205 0 FAGCEJ+AdvOTd877c31c Type 1C WinAnsi yes yes no 211 0 FAGCEK+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 216 0 FAGCEL+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 214 0 FAGCHL+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 221 0 FAGCHM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 222 0 FAGCIM+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 224 0 FAGHHP+AdvTT58d178b9+03 Type 1C Custom yes yes yes 235 0 FAGLDJ+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 238 0 FAGLHJ+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 239 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-28 03:09:46 CEST RepresentationInformation: fimmu-15-1445553_1.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-05-27 14:28:24 CEST Size: 698305 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 656 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation Destination: bmark_-79015807 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Study design and population Destination: s2_1 Item: Title: 2.2 ELISPOT assay determination and categorization Destination: s2_2 Item: Title: 2.3 CMV serologic IgG status Destination: s2_3 Item: Title: 2.4 Statistical analysis Destination: s2_4 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Patient characteristics Destination: s3_1 Item: Title: 3.2 CMV-specific cellular response Destination: s3_2 Item: Title: 3.3 Agreement between CMV IgG and CMV ELISPOT assay results Destination: s3_3 Item: Title: 3.4 Patient classification based on CMV-specific cellular response Destination: s3_4 Item: Title: 4 Discussion Destination: s4 Item: Title: 5 Conclusions Destination: s5 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: ELISPOT, infection risk, immunocompromised, pre-transplant, serology, CMV cell-mediated immunity, humoral immune response ID: 0xf9fb9f76fcad3133420eebfc908965e6, 0x86d4449a262d9c418352342018d05c11 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1181 ImageHeight: 779 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2279 ImageHeight: 787 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2290 ImageHeight: 791 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: FAFNOK+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: FAFNOK+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCIM+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FAGCIM+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAFNOL+AdvTT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FAFNOL+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAFNOM+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: FAFNOM+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAFNON+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: FAFNON+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCCI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: FAGCCI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAFNOO+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FAFNOO+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAGHHP+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: FAGHHP+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAGCCH+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: FAGCCH+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGLDJ+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FAGLDJ+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGLHJ+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: FAGLHJ+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FAGCCJ+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FAGCCJ+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAGBMH+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: FAGBMH+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FAGBOH+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: FAGBOH+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCEJ+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: FAGCEJ+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCEL+AdvTT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FAGCEL+AdvTT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAGCEK+AdvOT3f84ef53 FontSubset: true FirstChar: 103 LastChar: 103 FontDescriptor: FontName: FAGCEK+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAFNOH+AdvTTd3a5f740 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: FAFNOH+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCHL+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FAGCHL+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FAFNOI+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: FAFNOI+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAGCHM+AdvOT7d6df7ab.I FontSubset: true FirstChar: 60 LastChar: 120 FontDescriptor: FontName: FAGCHM+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FAFNOJ+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: FAFNOJ+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding XMP: Meritxell Boada-Pérez Cristina Berastegui Marta Erro Piedad Ussetti Elena Crespo Laura Donadeu Oriol Bestard Gabriel Anguera Amparo Solé Ricardo Ponz Mir Brian Molloy Eva Revilla-López Víctor Monforte Susana Gómez-Ollés Boada-Pérez M, Berastegui C, Erro M, Ussetti P, Crespo E, Donadeu L, Bestard O, Anguera G, Solé A, Ponz Mir R, Molloy B, Revilla-López E, Monforte V and Gómez-Ollés S (2024) Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation. Front. Immunol. 15:1445553 Copyright © 2025 Boada-Pérez, Berastegui, Erro, Ussetti, Crespo, Donadeu, Bestard, Anguera, Solé, Ponz Mir, Molloy, Revilla-López, Monforte and Gómez-Ollés. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ELISPOT infection risk immunocompromised pre-transplant serology CMV cell-mediated immunity humoral immune response Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation ELISPOT, infection risk, immunocompromised, pre-transplant, serology, CMV cell-mediated immunity, humoral immune response True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 520, 706 Annotation: Subtype: Link Rect: 221, 660, 523, 681 Annotation: Subtype: Link Rect: 221, 635, 523, 656 Annotation: Subtype: Link Rect: 221, 610, 473, 631 Annotation: Subtype: Link Rect: 221, 585, 503, 606 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 546, 159, 553 Annotation: Subtype: Link Rect: 49, 397, 159, 404 Annotation: Subtype: Link Rect: 155, 338, 180, 345 Annotation: Subtype: Link Rect: 49, 329, 168, 336 Annotation: Subtype: Link Rect: 450, 802, 506, 809 Annotation: Subtype: Link Rect: 466, 793, 519, 800 Annotation: Subtype: Link Rect: 446, 783, 539, 790 Annotation: Subtype: Link Rect: 49, 789, 233, 806 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 272, 518, 276, 527 Destination: 123 Annotation: Subtype: Link Rect: 281, 518, 285, 527 Destination: 123 Annotation: Subtype: Link Rect: 274, 493, 278, 502 Destination: 123 Annotation: Subtype: Link Rect: 283, 493, 287, 502 Destination: 123 Annotation: Subtype: Link Rect: 229, 481, 237, 490 Destination: 123 Annotation: Subtype: Link Rect: 242, 481, 251, 490 Destination: 123 Annotation: Subtype: Link Rect: 215, 443, 223, 452 Destination: 123 Annotation: Subtype: Link Rect: 135, 431, 144, 440 Destination: 123 Annotation: Subtype: Link Rect: 97, 393, 105, 402 Destination: 123 Annotation: Subtype: Link Rect: 110, 393, 119, 402 Destination: 123 Annotation: Subtype: Link Rect: 139, 331, 148, 340 Destination: 123 Annotation: Subtype: Link Rect: 277, 256, 285, 265 Destination: 123 Annotation: Subtype: Link Rect: 221, 206, 225, 215 Destination: 123 Annotation: Subtype: Link Rect: 229, 206, 238, 215 Destination: 123 Annotation: Subtype: Link Rect: 241, 206, 250, 215 Destination: 123 Annotation: Subtype: Link Rect: 190, 156, 198, 165 Destination: 123 Annotation: Subtype: Link Rect: 260, 118, 268, 127 Destination: 123 Annotation: Subtype: Link Rect: 175, 81, 184, 90 Destination: 123 Annotation: Subtype: Link Rect: 463, 481, 471, 490 Destination: 123 Annotation: Subtype: Link Rect: 476, 481, 485, 490 Destination: 158 Annotation: Subtype: Link Rect: 481, 256, 509, 265 Destination: 28 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 459, 131, 468, 140 Destination: 158 Annotation: Subtype: Link Rect: 472, 131, 481, 140 Destination: 158 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 143, 681, 152, 690 Destination: 158 Annotation: Subtype: Link Rect: 156, 681, 165, 690 Destination: 158 Annotation: Subtype: Link Rect: 211, 656, 219, 665 Destination: 158 Annotation: Subtype: Link Rect: 224, 656, 233, 665 Destination: 158 Annotation: Subtype: Link Rect: 237, 246, 246, 255 Destination: 158 Annotation: Subtype: Link Rect: 436, 744, 463, 753 Destination: 28 Annotation: Subtype: Link Rect: 452, 581, 501, 590 Destination: 54 Annotation: Subtype: Link Rect: 437, 556, 466, 565 Destination: 54 Annotation: Subtype: Link Rect: 307, 369, 334, 378 Destination: 67 Annotation: Subtype: Link Rect: 342, 369, 390, 378 Destination: 67 Annotation: Subtype: Link Rect: 370, 131, 397, 140 Destination: 84 Annotation: Subtype: Link Rect: 350, 81, 434, 90 Destination: 123 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 121, 459, 130, 468 Destination: 123 Annotation: Subtype: Link Rect: 135, 459, 144, 468 Destination: 158 Annotation: Subtype: Link Rect: 149, 459, 158, 468 Destination: 158 Annotation: Subtype: Link Rect: 326, 509, 335, 518 Destination: 158 Annotation: Subtype: Link Rect: 514, 409, 523, 418 Destination: 158 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 239, 608, 248, 617 Destination: 158 Annotation: Subtype: Link Rect: 94, 595, 103, 604 Destination: 123 Annotation: Subtype: Link Rect: 148, 558, 156, 567 Destination: 123 Annotation: Subtype: Link Rect: 101, 445, 110, 454 Destination: 158 Annotation: Subtype: Link Rect: 112, 370, 120, 379 Destination: 158 Annotation: Subtype: Link Rect: 209, 320, 218, 329 Destination: 158 Annotation: Subtype: Link Rect: 166, 308, 174, 317 Destination: 158 Annotation: Subtype: Link Rect: 371, 483, 380, 492 Destination: 123 Annotation: Subtype: Link Rect: 435, 308, 443, 317 Destination: 158 Annotation: Subtype: Link Rect: 308, 295, 316, 304 Destination: 158 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 164, 453, 173, 462 Destination: 158 Annotation: Subtype: Link Rect: 259, 428, 268, 437 Destination: 158 Annotation: Subtype: Link Rect: 52, 328, 61, 337 Destination: 158 Annotation: Subtype: Link Rect: 162, 303, 170, 312 Destination: 158 Annotation: Subtype: Link Rect: 250, 228, 258, 237 Destination: 158 Annotation: Subtype: Link Rect: 263, 228, 271, 237 Destination: 158 Annotation: Subtype: Link Rect: 197, 215, 205, 224 Destination: 158 Annotation: Subtype: Link Rect: 210, 215, 218, 224 Destination: 158 Annotation: Subtype: Link Rect: 279, 215, 287, 224 Destination: 158 Annotation: Subtype: Link Rect: 52, 140, 61, 149 Destination: 158 Annotation: Subtype: Link Rect: 260, 103, 268, 112 Destination: 158 Annotation: Subtype: Link Rect: 379, 578, 387, 587 Destination: 158 Annotation: Subtype: Link Rect: 400, 503, 408, 512 Destination: 158 Annotation: Subtype: Link Rect: 532, 440, 540, 449 Destination: 158 Annotation: Subtype: Link Rect: 385, 240, 394, 249 Destination: 158 Annotation: Subtype: Link Rect: 380, 228, 388, 237 Destination: 158 Annotation: Subtype: Link Rect: 395, 115, 403, 124 Destination: 158 Annotation: Subtype: Link Rect: 408, 115, 416, 124 Destination: 158 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 52, 756, 61, 765 Destination: 123 Annotation: Subtype: Link Rect: 67, 756, 75, 765 Destination: 158 Annotation: Subtype: Link Rect: 81, 756, 90, 765 Destination: 158 Annotation: Subtype: Link Rect: 94, 706, 103, 715 Destination: 158 Annotation: Subtype: Link Rect: 163, 644, 171, 653 Destination: 123 Annotation: Subtype: Link Rect: 177, 644, 185, 653 Destination: 158 Annotation: Subtype: Link Rect: 191, 644, 200, 653 Destination: 158 Annotation: Subtype: Link Rect: 124, 319, 132, 328 Destination: 123 Annotation: Subtype: Link Rect: 275, 244, 285, 253 Destination: 123 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 315, 503, 545, 512 Annotation: Subtype: Link Rect: 304, 491, 403, 500 Annotation: Subtype: Link Rect: 62, 362, 139, 369 Annotation: Subtype: Link Rect: 62, 327, 134, 334 Annotation: Subtype: Link Rect: 163, 308, 257, 315 Annotation: Subtype: Link Rect: 97, 273, 202, 280 Annotation: Subtype: Link Rect: 209, 254, 274, 261 Annotation: Subtype: Link Rect: 123, 227, 199, 234 Annotation: Subtype: Link Rect: 157, 200, 231, 207 Annotation: Subtype: Link Rect: 173, 173, 267, 180 Annotation: Subtype: Link Rect: 163, 138, 261, 145 Annotation: Subtype: Link Rect: 111, 122, 155, 129 Annotation: Subtype: Link Rect: 186, 98, 272, 105 Annotation: Subtype: Link Rect: 172, 71, 253, 78 Annotation: Subtype: Link Rect: 519, 362, 545, 369 Annotation: Subtype: Link Rect: 304, 354, 372, 361 Annotation: Subtype: Link Rect: 519, 335, 545, 342 Annotation: Subtype: Link Rect: 304, 327, 349, 334 Annotation: Subtype: Link Rect: 410, 292, 486, 299 Annotation: Subtype: Link Rect: 522, 265, 545, 272 Annotation: Subtype: Link Rect: 304, 257, 375, 264 Annotation: Subtype: Link Rect: 317, 222, 392, 229 Annotation: Subtype: Link Rect: 415, 179, 496, 186 Annotation: Subtype: Link Rect: 459, 152, 545, 159 Annotation: Subtype: Link Rect: 404, 133, 453, 140 Annotation: Subtype: Link Rect: 452, 106, 519, 113 Annotation: Subtype: Link Rect: 437, 71, 490, 78 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 181, 742, 263, 749 Annotation: Subtype: Link Rect: 197, 715, 279, 722 Annotation: Subtype: Link Rect: 263, 680, 290, 687 Annotation: Subtype: Link Rect: 49, 672, 113, 679 Annotation: Subtype: Link Rect: 62, 637, 123, 644 Annotation: Subtype: Link Rect: 62, 602, 111, 609 Annotation: Subtype: Link Rect: 97, 567, 153, 574 Annotation: Subtype: Link Rect: 163, 548, 210, 555 Annotation: Subtype: Link Rect: 114, 529, 202, 536 Annotation: Subtype: Link Rect: 62, 494, 154, 501 Annotation: Subtype: Link Rect: 62, 459, 111, 466 Annotation: Subtype: Link Rect: 160, 424, 238, 431 Annotation: Subtype: Link Rect: 94, 389, 156, 396 Annotation: Subtype: Link Rect: 226, 362, 288, 369 Annotation: Subtype: Link Rect: 247, 335, 290, 342 Annotation: Subtype: Link Rect: 49, 327, 101, 334 Annotation: Subtype: Link Rect: 211, 292, 263, 299 Annotation: Subtype: Link Rect: 421, 742, 508, 749 Annotation: Subtype: Link Rect: 484, 715, 533, 722 Annotation: Subtype: Link Rect: 317, 680, 412, 687 Annotation: Subtype: Link Rect: 356, 645, 443, 652 Annotation: Subtype: Link Rect: 374, 610, 453, 617 Annotation: Subtype: Link Rect: 447, 567, 534, 574 Annotation: Subtype: Link Rect: 520, 540, 545, 547 Annotation: Subtype: Link Rect: 304, 532, 365, 539 Annotation: Subtype: Link Rect: 380, 497, 471, 504 Annotation: Subtype: Link Rect: 455, 478, 521, 485 Annotation: Subtype: Link Rect: 424, 451, 492, 458 Annotation: Subtype: Link Rect: 317, 416, 412, 423 Annotation: Subtype: Link Rect: 502, 389, 545, 396 Annotation: Subtype: Link Rect: 304, 381, 356, 388 Annotation: Subtype: Link Rect: 415, 346, 517, 353 Annotation: Subtype: Link Rect: 353, 319, 442, 326 Annotation: Subtype: Link Rect: 366, 292, 449, 299 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: c00636c4 Type: CRC32 Checksum: a5e8296e8fd12104d4888fd63f995982 Type: MD5 Checksum: c508c8486a57047f69ae27285e8add2cce5fcc82 Type: SHA-1 Checksum: aa845a961616d585c1e96814763b6bdba157f27da0422a3a334fb77486d6d6ad Type: SHA-256