873096b15d3e1c963950b486c288c73b A_New_Prognostic_Score_Based.pdf cb42038ed64521d08640a81230c17eb5af705180 A_New_Prognostic_Score_Based.pdf b80efcc282c3fcae41961448d1b89287825e615f1fb8e5baba2c283183e6b405 A_New_Prognostic_Score_Based.pdf Title: A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation Subject: Kidney International Reports, 10 (2025) 3044-3057. doi:10.1016/j.ekir.2025.06.056 Author: Delphine Kervella Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Aug 19 15:17:21 2025 CEST ModDate: Sat Aug 30 06:49:56 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1370446 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AKBGLH+AdvOT3bf1a849.B Type 1C WinAnsi yes yes no 670 0 AKBGMI+AdvOT0de51fd2 Type 1C WinAnsi yes yes no 672 0 AKBGNI+AdvOT0de51fd2+20 Type 1C WinAnsi yes yes no 676 0 AKBGNJ+AdvPS3F4C13 Type 1C WinAnsi yes yes no 681 0 AKBGNK+AdvOT0de51fd2+fb Type 1C Custom yes yes yes 679 0 AKBHCA+AdvP4C4E74 Type 1C Custom yes yes yes 294 0 AKBHCB+AdvOTa84cfff1.I+20 Type 1C WinAnsi yes yes no 295 0 AKBHAK+AdvOTa84cfff1.I Type 1C WinAnsi yes yes no 272 0 AKBHAL+AdvP4C4E51 Type 1C WinAnsi yes yes no 290 0 AKBHAM+AdvPSSym Type 1C WinAnsi yes yes no 291 0 AKBHAN+AdvOT7bedbc7e Type 1C WinAnsi yes yes no 278 0 AKBHBO+AdvOT7bedbc7e+fb Type 1C Custom yes yes yes 281 0 AKBHBP+AdvOT7bedbc7e+20 Type 1C WinAnsi yes yes no 298 0 AKBHDC+AdvOT372b1957.I Type 1C WinAnsi yes yes no 312 0 AKBINI+AdvOT0a81dd96.B Type 1C WinAnsi yes yes no 304 0 AKBINJ+AdvOTb4959fff Type 1C WinAnsi yes yes no 302 0 AKBIOK+AdvOT0c7211e1.I Type 1C WinAnsi yes yes no 306 0 AKBJAK+AdvOTaf810ba6 Type 1C WinAnsi yes yes no 333 0 AKBJAL+AdvPS3FDD77 Type 1C WinAnsi yes yes no 331 0 AKBJAM+AdvPS44A44B Type 1C WinAnsi yes yes no 324 0 AKBJAN+AdvOT2c6df7a6 Type 1C WinAnsi yes yes no 327 0 AKBJAO+AdvOT2c6df7a6+20 Type 1C WinAnsi yes yes no 335 0 AKBJAP+AdvOT863180fb+02 Type 1C MacRoman yes yes no 336 0 AKBJCA+AdvOT2c6df7a6+fb Type 1C Custom yes yes yes 316 0 AKBJGP+Arial-BoldMT CID TrueType Identity-H yes yes yes 351 0 AKBJHA+Calibri-Bold CID TrueType Identity-H yes yes yes 352 0 AKBJHB+TimesNewRomanPS-BoldMT CID TrueType Identity-H yes yes yes 355 0 AKBJIC+ArialMT CID TrueType Identity-H yes yes yes 366 0 AKBJKC+AdvOTb4959fff+20 Type 1C WinAnsi yes yes no 367 0 AKBJKD+AdvOTb4959fff+fb Type 1C Custom yes yes yes 373 0 AKBKAD+Calibri CID TrueType Identity-H yes yes yes 389 0 AKBJOC+AdvOTd40fda3b.B Type 1C WinAnsi yes yes no 378 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-28 03:09:41 CEST RepresentationInformation: A_New_Prognostic_Score_Based.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-05-27 15:23:40 CEST Size: 1370446 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 767 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation Destination: titlink1 Children: Item: Title: Methods Destination: flink1 Children: Item: Title: Study Design and Patients Destination: slink1 Children: Item: Title: Derivation Cohorts Destination: thirlink1 Item: Title: Validation Cohort Destination: thirlink2 Item: Title: CMV-CMI Destination: slink2 Item: Title: Definition of Main CMV Outcomes Destination: slink3 Item: Title: Development of the CMV-CMI Risk Score Destination: slink4 Item: Title: Types of CMV Preventive Therapies Destination: slink5 Item: Title: Statistical Analysis Destination: slink6 Item: Title: Results Destination: flink2 Children: Item: Title: Characteristics of the Derivation Cohort Destination: slink7 Item: Title: Frequencies of CMV-CMI, Absolute Lymphocyte Counts and CMV Infection Rates in the Derivation Cohort Destination: slink8 Item: Title: Development of a CMV-CMI Risk-Score for Immune Stratification Destination: slink9 Item: Title: Performance of the CMV-CMI Risk-Score in Distinct Clinical Settings and Derivation Cohorts Destination: slink10 Item: Title: Prospective Validation of the CMV-CMI Risk-Score Destination: slink11 Item: Title: Integrative Prognostic Model for the Risk of CSI Destination: slink12 Item: Title: Discussion Destination: flink3 Item: Title: Disclosure Destination: flink4 Item: Title: Acknowledgments Destination: flink5 Children: Item: Title: Funding Destination: slink13 Item: Title: Data Availability Statement Destination: flink6 Item: Title: Supplementary Material Destination: flink7 Item: Title: References Destination: blink1 Info: Title: A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation Author: Delphine Kervella Subject: Kidney International Reports, 10 (2025) 3044-3057. doi:10.1016/j.ekir.2025.06.056 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Aug 19 15:47:21 CEST 2025 ModDate: Sat Aug 30 07:19:56 CEST 2025 ID: 0x8cf8fb3b7a7f5dff2429239923fa57be, 0xd8363e2f493d1941a287cd7c2dd9f32d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2048 ImageHeight: 928 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 6 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 9 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 9 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 141 ImageHeight: 445 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 556 ImageHeight: 445 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 742 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 984 ImageHeight: 298 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 563 ImageHeight: 446 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 563 ImageHeight: 446 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 142 ImageHeight: 298 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2093 ImageHeight: 1134 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: AKBJHA+Calibri-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: AKBJHB+TimesNewRomanPS-BoldMT Encoding: Identity-H ToUnicode: true Font: BaseFont: AKBKAD+Calibri Encoding: Identity-H ToUnicode: true Font: BaseFont: AKBJIC+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: AKBJGP+Arial-BoldMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: AKBJAM+AdvPS44A44B FontSubset: true FirstChar: 68 LastChar: 76 FontDescriptor: FontName: AKBJAM+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJAN+AdvOT2c6df7a6 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: AKBJAN+AdvOT2c6df7a6 Flags: Nonsymbolic FontBBox: -41, -208, 822, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJAL+AdvPS3FDD77 FontSubset: true FirstChar: 91 LastChar: 91 FontDescriptor: FontName: AKBJAL+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJAK+AdvOTaf810ba6 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: AKBJAK+AdvOTaf810ba6 Flags: Nonsymbolic FontBBox: -41, -218, 833, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJAO+AdvOT2c6df7a6+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: AKBJAO+AdvOT2c6df7a6+20 Flags: Nonsymbolic FontBBox: -166, -114, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHAK+AdvOTa84cfff1.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: AKBHAK+AdvOTa84cfff1.I Flags: Nonsymbolic FontBBox: -41, -270, 1135, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJAP+AdvOT863180fb+02 FontSubset: true FirstChar: 255 LastChar: 255 FontDescriptor: FontName: AKBJAP+AdvOT863180fb+02 Flags: Nonsymbolic FontBBox: 0, -208, 375, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: AKBHAN+AdvOT7bedbc7e FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: AKBHAN+AdvOT7bedbc7e Flags: Serif, Nonsymbolic FontBBox: -62, -291, 937, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHBO+AdvOT7bedbc7e+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AKBHBO+AdvOT7bedbc7e+fb Flags: Symbolic FontBBox: 0, 0, 781, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AKBGLH+AdvOT3bf1a849.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: AKBGLH+AdvOT3bf1a849.B Flags: Nonsymbolic FontBBox: -31, -250, 989, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBGMI+AdvOT0de51fd2 FontSubset: true FirstChar: 34 LastChar: 252 FontDescriptor: FontName: AKBGMI+AdvOT0de51fd2 Flags: Nonsymbolic FontBBox: -10, -250, 989, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHAL+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: AKBHAL+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHAM+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: AKBHAM+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBGNI+AdvOT0de51fd2+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AKBGNI+AdvOT0de51fd2+20 Flags: Nonsymbolic FontBBox: -166, -125, 979, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHCA+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: AKBHCA+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AKBGNK+AdvOT0de51fd2+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AKBGNK+AdvOT0de51fd2+fb Flags: Symbolic FontBBox: 0, 0, 520, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AKBHCB+AdvOTa84cfff1.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: AKBHCB+AdvOTa84cfff1.I+20 Flags: Nonsymbolic FontBBox: -166, -125, 1031, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBGNJ+AdvPS3F4C13 FontSubset: true FirstChar: 99 LastChar: 103 FontDescriptor: FontName: AKBGNJ+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBHBP+AdvOT7bedbc7e+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AKBHBP+AdvOT7bedbc7e+20 Flags: Nonsymbolic FontBBox: -135, -343, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBINJ+AdvOTb4959fff FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: AKBINJ+AdvOTb4959fff Flags: Nonsymbolic FontBBox: -31, -250, 875, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJKC+AdvOTb4959fff+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AKBJKC+AdvOTb4959fff+20 Flags: Nonsymbolic FontBBox: -156, -104, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBINI+AdvOT0a81dd96.B FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: AKBINI+AdvOT0a81dd96.B Flags: Nonsymbolic FontBBox: -72, -250, 885, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBIOK+AdvOT0c7211e1.I FontSubset: true FirstChar: 45 LastChar: 110 FontDescriptor: FontName: AKBIOK+AdvOT0c7211e1.I Flags: Nonsymbolic FontBBox: -41, -260, 1031, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJKD+AdvOTb4959fff+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: AKBJKD+AdvOTb4959fff+fb Flags: Symbolic FontBBox: 0, 0, 500, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AKBHDC+AdvOT372b1957.I FontSubset: true FirstChar: 80 LastChar: 116 FontDescriptor: FontName: AKBHDC+AdvOT372b1957.I Flags: Nonsymbolic FontBBox: -93, -270, 1031, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJOC+AdvOTd40fda3b.B FontSubset: true FirstChar: 41 LastChar: 41 FontDescriptor: FontName: AKBJOC+AdvOTd40fda3b.B Flags: Nonsymbolic FontBBox: -62, -208, 979, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AKBJCA+AdvOT2c6df7a6+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: AKBJCA+AdvOT2c6df7a6+fb Flags: Symbolic FontBBox: 0, 0, 364, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: AKBJIC+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKBJIC+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true Font: BaseFont: AKBKAD+Calibri CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKBKAD+Calibri Flags: Symbolic FontBBox: -503, -313, 1240, 1026 FontFile2: true Font: BaseFont: AKBJHA+Calibri-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKBJHA+Calibri-Bold Flags: Symbolic FontBBox: -519, -349, 1263, 1039 FontFile2: true Font: BaseFont: AKBJHB+TimesNewRomanPS-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKBJHB+TimesNewRomanPS-BoldMT Flags: Serif, Symbolic FontBBox: -558, -328, 2000, 1056 FontFile2: true Font: BaseFont: AKBJGP+Arial-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKBJGP+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile2: true XMP: application/pdf doi:10.1016/j.ekir.2025.06.056 A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation Delphine Kervella Franc Casanova-Ferrer Camille N. Kotton Laura Donadeu Deepali Kumar Silvia Pineda Elena Crespo Maria Meneghini José González-Costelo Elena García-Romero Laura Lladó Alba Cachero Edoardo Melilli Irina B. Torres Anna Martínez-Lacalle Zaira Castañeda Mónica Martinez-Gallo Oscar Len Ibai Los-Arcos Enric Trilla-Herrera Enric Miret Magali Giral Sophie Brouard François R. Girardin Jean Villard Klemens Budde Carmen Lefaucheur Alexandre Loupy Francesc Moreso Oriol Bestard cell-mediated immunity CMV infection monitoring solid organ transplantation Kidney International Reports, 10 (2025) 3044-3057. doi:10.1016/j.ekir.2025.06.056 International Society of Nephrology journal Kidney International Reports © 2025 International Society of Nephrology. Published by Elsevier Inc. 2468-0249 10 9 September 2025 3044-3057 3044 3057 10.1016/j.ekir.2025.06.056 https://doi.org/10.1016/j.ekir.2025.06.056 2010-04-23 true 10.1016/j.ekir.2025.06.056 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.ekir.2025.06.056 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2025-08-19T18:47:21+05:30 2025-08-30T10:19:56+05:30 2025-08-30T10:19:56+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:3bbb6213-ed45-4c1a-93ef-3ff8c183b1ba uuid:e54b3f98-84e4-46a1-8965-51f84dbe7052 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 3044 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 162, 617, 162, 619 Annotation: Subtype: Link Rect: 162, 620, 167, 631 Destination: 541 Annotation: Subtype: Link Rect: 169, 620, 174, 631 Destination: 541 Annotation: Subtype: Link Rect: 176, 620, 181, 631 Destination: 541 Annotation: Subtype: Link Rect: 304, 617, 304, 619 Annotation: Subtype: Link Rect: 304, 620, 308, 631 Destination: 541 Annotation: Subtype: Link Rect: 310, 620, 315, 631 Destination: 541 Annotation: Subtype: Link Rect: 413, 617, 413, 619 Annotation: Subtype: Link Rect: 413, 620, 417, 631 Destination: 541 Annotation: Subtype: Link Rect: 503, 617, 503, 619 Annotation: Subtype: Link Rect: 503, 620, 507, 631 Destination: 541 Annotation: Subtype: Link Rect: 510, 620, 514, 631 Destination: 541 Annotation: Subtype: Link Rect: 148, 603, 148, 605 Annotation: Subtype: Link Rect: 148, 606, 153, 617 Destination: 541 Annotation: Subtype: Link Rect: 226, 603, 226, 605 Annotation: Subtype: Link Rect: 226, 606, 231, 617 Destination: 541 Annotation: Subtype: Link Rect: 305, 603, 305, 605 Annotation: Subtype: Link Rect: 305, 606, 310, 617 Destination: 541 Annotation: Subtype: Link Rect: 312, 606, 317, 617 Destination: 541 Annotation: Subtype: Link Rect: 411, 603, 411, 605 Annotation: Subtype: Link Rect: 411, 606, 416, 617 Destination: 541 Annotation: Subtype: Link Rect: 418, 606, 422, 617 Destination: 541 Annotation: Subtype: Link Rect: 425, 606, 429, 617 Destination: 541 Annotation: Subtype: Link Rect: 188, 589, 188, 591 Annotation: Subtype: Link Rect: 188, 592, 192, 603 Destination: 541 Annotation: Subtype: Link Rect: 308, 589, 308, 591 Annotation: Subtype: Link Rect: 308, 592, 313, 603 Destination: 541 Annotation: Subtype: Link Rect: 380, 589, 380, 591 Annotation: Subtype: Link Rect: 380, 592, 385, 603 Destination: 541 Annotation: Subtype: Link Rect: 461, 589, 461, 591 Annotation: Subtype: Link Rect: 461, 592, 465, 603 Destination: 541 Annotation: Subtype: Link Rect: 150, 575, 150, 577 Annotation: Subtype: Link Rect: 150, 578, 154, 589 Destination: 541 Annotation: Subtype: Link Rect: 234, 575, 234, 577 Annotation: Subtype: Link Rect: 234, 578, 239, 589 Destination: 541 Annotation: Subtype: Link Rect: 241, 578, 245, 589 Destination: 541 Annotation: Subtype: Link Rect: 248, 578, 252, 589 Destination: 541 Annotation: Subtype: Link Rect: 373, 575, 373, 577 Annotation: Subtype: Link Rect: 373, 578, 378, 589 Destination: 541 Annotation: Subtype: Link Rect: 380, 578, 384, 589 Destination: 541 Annotation: Subtype: Link Rect: 474, 575, 474, 577 Annotation: Subtype: Link Rect: 474, 578, 479, 589 Destination: 541 Annotation: Subtype: Link Rect: 481, 578, 486, 589 Destination: 541 Annotation: Subtype: Link Rect: 488, 578, 492, 589 Destination: 541 Annotation: Subtype: Link Rect: 188, 561, 188, 563 Annotation: Subtype: Link Rect: 188, 564, 197, 575 Destination: 541 Annotation: Subtype: Link Rect: 199, 564, 204, 575 Destination: 541 Annotation: Subtype: Link Rect: 262, 561, 262, 563 Annotation: Subtype: Link Rect: 262, 564, 272, 575 Destination: 541 Annotation: Subtype: Link Rect: 274, 564, 278, 575 Destination: 541 Annotation: Subtype: Link Rect: 358, 561, 358, 563 Annotation: Subtype: Link Rect: 358, 564, 367, 575 Destination: 541 Annotation: Subtype: Link Rect: 370, 564, 374, 575 Destination: 541 Annotation: Subtype: Link Rect: 478, 561, 478, 563 Annotation: Subtype: Link Rect: 478, 564, 487, 575 Destination: 541 Annotation: Subtype: Link Rect: 490, 564, 494, 575 Destination: 541 Annotation: Subtype: Link Rect: 128, 547, 128, 549 Annotation: Subtype: Link Rect: 128, 550, 137, 561 Destination: 541 Annotation: Subtype: Link Rect: 139, 550, 144, 561 Destination: 541 Annotation: Subtype: Link Rect: 214, 547, 214, 549 Annotation: Subtype: Link Rect: 214, 550, 223, 561 Destination: 541 Annotation: Subtype: Link Rect: 311, 547, 311, 549 Annotation: Subtype: Link Rect: 311, 550, 320, 561 Destination: 541 Annotation: Subtype: Link Rect: 429, 547, 429, 549 Annotation: Subtype: Link Rect: 429, 550, 438, 561 Destination: 541 Annotation: Subtype: Link Rect: 506, 547, 506, 549 Annotation: Subtype: Link Rect: 506, 550, 515, 561 Destination: 541 Annotation: Subtype: Link Rect: 153, 533, 153, 535 Annotation: Subtype: Link Rect: 153, 536, 162, 547 Destination: 541 Annotation: Subtype: Link Rect: 270, 533, 270, 535 Annotation: Subtype: Link Rect: 270, 536, 279, 547 Destination: 541 Annotation: Subtype: Link Rect: 374, 533, 374, 535 Annotation: Subtype: Link Rect: 374, 536, 383, 547 Destination: 541 Annotation: Subtype: Link Rect: 385, 536, 394, 547 Destination: 541 Annotation: Subtype: Link Rect: 489, 533, 489, 535 Annotation: Subtype: Link Rect: 489, 536, 493, 547 Destination: 541 Annotation: Subtype: Link Rect: 496, 536, 500, 547 Destination: 541 Annotation: Subtype: Link Rect: 502, 536, 507, 547 Destination: 541 Annotation: Subtype: Link Rect: 140, 519, 140, 521 Annotation: Subtype: Link Rect: 140, 522, 144, 533 Destination: 541 Annotation: Subtype: Link Rect: 146, 522, 151, 533 Destination: 541 Annotation: Subtype: Link Rect: 153, 522, 158, 533 Destination: 541 Annotation: Subtype: Link Rect: 274, 59, 293, 67 Annotation: Subtype: Link Rect: 48, 49, 137, 57 Annotation: Subtype: Link Rect: 484, 704, 562, 719 Page: Label: 3045 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 221, 593, 379, 601 Annotation: Subtype: Link Rect: 135, 560, 332, 568 Annotation: Subtype: Link Rect: 123, 468, 127, 479 Destination: 174 Annotation: Subtype: Link Rect: 252, 429, 256, 440 Destination: 174 Annotation: Subtype: Link Rect: 82, 377, 86, 388 Destination: 174 Annotation: Subtype: Link Rect: 259, 352, 262, 362 Destination: 174 Annotation: Subtype: Link Rect: 265, 352, 269, 362 Destination: 174 Annotation: Subtype: Link Rect: 158, 313, 168, 324 Destination: 174 Annotation: Subtype: Link Rect: 105, 222, 109, 233 Destination: 174 Annotation: Subtype: Link Rect: 111, 222, 126, 233 Destination: 174 Annotation: Subtype: Link Rect: 121, 183, 139, 194 Destination: 174 Annotation: Subtype: Link Rect: 233, 157, 237, 168 Destination: 174 Annotation: Subtype: Link Rect: 183, 105, 191, 116 Destination: 174 Annotation: Subtype: Link Rect: 193, 105, 201, 116 Destination: 174 Annotation: Subtype: Link Rect: 160, 80, 179, 90 Destination: 174 Annotation: Subtype: Link Rect: 320, 171, 357, 182 Destination: 26 Annotation: Subtype: Link Rect: 401, 118, 409, 129 Destination: 174 Annotation: Subtype: Link Rect: 411, 118, 419, 129 Destination: 174 Annotation: Subtype: Link Rect: 421, 118, 429, 129 Destination: 174 Page: Label: 3046 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 126, 450, 160, 461 Destination: 37 Annotation: Subtype: Link Rect: 222, 390, 229, 401 Destination: 174 Annotation: Subtype: Link Rect: 264, 312, 272, 323 Destination: 174 Annotation: Subtype: Link Rect: 230, 247, 238, 258 Destination: 174 Annotation: Subtype: Link Rect: 440, 74, 478, 85 Destination: 26 Page: Label: 3047 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 241, 414, 276, 425 Destination: 46 Annotation: Subtype: Link Rect: 51, 102, 161, 112 Destination: 166 Annotation: Subtype: Link Rect: 167, 106, 174, 117 Destination: 174 Annotation: Subtype: Link Rect: 290, 53, 293, 64 Destination: 174 Annotation: Subtype: Link Rect: 457, 445, 465, 456 Destination: 174 Page: Label: 3048 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 223, 53, 227, 64 Destination: 174 Annotation: Subtype: Link Rect: 443, 243, 556, 254 Destination: 166 Annotation: Subtype: Link Rect: 463, 559, 466, 566 Destination: 46 Page: Label: 3049 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 496, 422, 504, 432 Destination: 174 Annotation: Subtype: Link Rect: 506, 422, 514, 432 Destination: 174 Annotation: Subtype: Link Rect: 359, 294, 396, 305 Destination: 26 Annotation: Subtype: Link Rect: 420, 294, 453, 305 Destination: 37 Annotation: Subtype: Link Rect: 443, 61, 555, 72 Destination: 166 Page: Label: 3050 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 51, 494, 87, 505 Destination: 53 Annotation: Subtype: Link Rect: 242, 482, 283, 493 Destination: 53 Annotation: Subtype: Link Rect: 137, 456, 254, 467 Destination: 166 Annotation: Subtype: Link Rect: 277, 456, 287, 467 Destination: 166 Annotation: Subtype: Link Rect: 152, 417, 269, 428 Destination: 166 Annotation: Subtype: Link Rect: 171, 378, 283, 389 Destination: 166 Annotation: Subtype: Link Rect: 190, 307, 227, 318 Destination: 67 Annotation: Subtype: Link Rect: 151, 126, 268, 137 Destination: 166 Annotation: Subtype: Link Rect: 92, 113, 128, 124 Destination: 67 Annotation: Subtype: Link Rect: 378, 420, 416, 431 Destination: 100 Annotation: Subtype: Link Rect: 320, 187, 438, 198 Destination: 166 Annotation: Subtype: Link Rect: 426, 174, 539, 185 Destination: 166 Annotation: Subtype: Link Rect: 407, 161, 531, 172 Destination: 166 Annotation: Subtype: Link Rect: 414, 122, 532, 133 Destination: 166 Annotation: Subtype: Link Rect: 320, 48, 353, 59 Destination: 46 Page: Label: 3051 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 192, 322, 229, 333 Destination: 100 Annotation: Subtype: Link Rect: 253, 322, 287, 333 Destination: 115 Page: Label: 3052 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 429, 722, 535, 733 Destination: 166 Annotation: Subtype: Link Rect: 557, 722, 562, 733 Destination: 166 Annotation: Subtype: Link Rect: 337, 709, 455, 720 Destination: 166 Annotation: Subtype: Link Rect: 320, 566, 439, 577 Destination: 166 Annotation: Subtype: Link Rect: 437, 514, 555, 525 Destination: 166 Annotation: Subtype: Link Rect: 448, 453, 482, 464 Destination: 133 Annotation: Subtype: Link Rect: 320, 388, 359, 399 Destination: 133 Annotation: Subtype: Link Rect: 320, 310, 360, 321 Destination: 153 Annotation: Subtype: Link Rect: 412, 271, 454, 282 Destination: 153 Annotation: Subtype: Link Rect: 495, 271, 562, 282 Destination: 166 Annotation: Subtype: Link Rect: 317, 258, 365, 269 Destination: 166 Annotation: Subtype: Link Rect: 379, 233, 420, 243 Destination: 153 Annotation: Subtype: Link Rect: 492, 207, 531, 218 Destination: 153 Annotation: Subtype: Link Rect: 408, 194, 446, 205 Destination: 153 Page: Label: 3053 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 433, 401, 440, 412 Destination: 174 Annotation: Subtype: Link Rect: 442, 401, 450, 412 Destination: 174 Annotation: Subtype: Link Rect: 452, 401, 460, 412 Destination: 174 Annotation: Subtype: Link Rect: 462, 401, 470, 412 Destination: 174 Annotation: Subtype: Link Rect: 472, 401, 480, 412 Destination: 246 Page: Label: 3054 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 152, 280, 190, 291 Destination: 133 Annotation: Subtype: Link Rect: 79, 181, 97, 192 Destination: 174 Annotation: Subtype: Link Rect: 99, 181, 107, 192 Destination: 246 Annotation: Subtype: Link Rect: 272, 77, 280, 88 Destination: 246 Annotation: Subtype: Link Rect: 342, 246, 350, 257 Destination: 246 Annotation: Subtype: Link Rect: 497, 233, 505, 244 Destination: 246 Annotation: Subtype: Link Rect: 507, 233, 515, 244 Destination: 246 Page: Label: 3055 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 183, 688, 191, 699 Destination: 174 Annotation: Subtype: Link Rect: 193, 688, 201, 699 Destination: 174 Annotation: Subtype: Link Rect: 317, 658, 425, 667 Page: Label: 3056 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 168, 622, 286, 630 Annotation: Subtype: Link Rect: 84, 575, 246, 583 Annotation: Subtype: Link Rect: 202, 539, 293, 547 Annotation: Subtype: Link Rect: 66, 528, 108, 536 Annotation: Subtype: Link Rect: 227, 481, 293, 489 Annotation: Subtype: Link Rect: 66, 470, 119, 478 Annotation: Subtype: Link Rect: 132, 434, 289, 442 Annotation: Subtype: Link Rect: 88, 388, 265, 395 Annotation: Subtype: Link Rect: 66, 330, 214, 338 Annotation: Subtype: Link Rect: 172, 272, 292, 280 Annotation: Subtype: Link Rect: 132, 225, 250, 233 Annotation: Subtype: Link Rect: 110, 167, 232, 175 Annotation: Subtype: Link Rect: 229, 120, 293, 128 Annotation: Subtype: Link Rect: 67, 109, 126, 117 Annotation: Subtype: Link Rect: 254, 62, 293, 70 Annotation: Subtype: Link Rect: 67, 51, 194, 59 Annotation: Subtype: Link Rect: 463, 692, 562, 700 Annotation: Subtype: Link Rect: 336, 681, 364, 689 Annotation: Subtype: Link Rect: 371, 623, 497, 631 Annotation: Subtype: Link Rect: 523, 576, 562, 584 Annotation: Subtype: Link Rect: 336, 565, 414, 573 Annotation: Subtype: Link Rect: 367, 508, 537, 516 Annotation: Subtype: Link Rect: 523, 472, 562, 480 Annotation: Subtype: Link Rect: 336, 461, 444, 469 Annotation: Subtype: Link Rect: 410, 414, 528, 422 Annotation: Subtype: Link Rect: 478, 356, 562, 364 Annotation: Subtype: Link Rect: 336, 345, 417, 353 Annotation: Subtype: Link Rect: 375, 298, 540, 306 Annotation: Subtype: Link Rect: 498, 251, 562, 259 Annotation: Subtype: Link Rect: 336, 240, 404, 248 Annotation: Subtype: Link Rect: 467, 193, 562, 201 Annotation: Subtype: Link Rect: 336, 182, 362, 190 Annotation: Subtype: Link Rect: 401, 113, 527, 121 Annotation: Subtype: Link Rect: 415, 78, 546, 86 Page: Label: 3057 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 175, 736, 293, 744 Annotation: Subtype: Link Rect: 67, 725, 134, 733 Annotation: Subtype: Link Rect: 124, 667, 242, 675 Annotation: Subtype: Link Rect: 67, 610, 233, 618 Annotation: Subtype: Link Rect: 67, 574, 214, 582 Annotation: Subtype: Link Rect: 474, 703, 562, 711 Annotation: Subtype: Link Rect: 336, 692, 424, 700 Annotation: Subtype: Link Rect: 508, 645, 562, 653 Annotation: Subtype: Link Rect: 336, 634, 408, 642 Annotation: Subtype: Link Rect: 435, 588, 562, 596 Annotation: Subtype: Link Rect: 336, 577, 353, 585 Checksum: a024bd8f Type: CRC32 Checksum: 873096b15d3e1c963950b486c288c73b Type: MD5 Checksum: cb42038ed64521d08640a81230c17eb5af705180 Type: SHA-1 Checksum: b80efcc282c3fcae41961448d1b89287825e615f1fb8e5baba2c283183e6b405 Type: SHA-256