d97a958fb2308679d76aae9fcc926fe1 vdaf003.pdf 014b968beee81367c13de2d7baa3f412f700169a vdaf003.pdf a0de94740316879aecac6746c5cafdb8584133d90a5ccda21cd977d0f24f38b9 vdaf003.pdf Title: Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond   Subject: DOI: 10.1093/noajnl/vdaf003 , Volume. 7, Issue. 1, 8 January 2025 Abstract Background. Cognitive impairment (CI) significantly impacts the quality of life of glioma patients. The main contributing risk factors include tumor characteristics, treatment-related factors, and their complex interplay. This review explores the role of advanced structural neuroimaging techniques in understanding CI in glioma patients. Methods. A literature search was conducted in PubMed, PsycINFO, and ISI Web of Knowledge using specific keywords. We included studies with advanced magnetic resonance imaging techniques and objective neuropsychological exams. Results. At diagnosis, during the pre-surgery phase, associations between glioma characteristics and cognitive outcomes have been described. Specifically, patients with isocitrate dehydrogenase (IDH)-wild-type gliomas exhibit more adverse cognitive outcomes, accompanied by disruptions in gray (GM) and white matter (WM) networks when compared to IDH-mutant. In addition, pre- and post-surgery imaging analyses highlight the importance of preserving specific WM tracts, such as the inferior longitudinal and arcuate fasciculus, in mitigating verbal memory and language processing decline. Furthermore, examining gliomas in perisylvian regions emphasizes deleterious effects on various cognitive domains. Additionally, it has been suggested that neuroplastic reorganization could serve as a compensatory mechanism against CI. Lastly, a limited number of studies suggest long-term CI linked to GM atrophy and leukoencephalopathy induced by radiotherapy ± chemotherapy in glioma survivors, highlighting the need for improving treatment approaches, particularly for patients with extended survival expectations. Conclusion. This review underscores the need for nuanced understanding and an individual approach in the management of glioma patients. Neuroplastic insights offer clinicians valuable guidance in surgical decision-making and personalized therapeutic approaches thus improving patient outcomes in neuro-oncology. Author: Nuria Cayuela, ,Cristina Izquierdo, ,Lucía Vaquero, ,Estela Càmara, ,Jordi Bruna,Marta Simó Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Tue Feb 4 22:08:21 2025 CET ModDate: Tue Feb 4 22:09:58 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 594 x 783 pts Page rot: 0 File size: 2054435 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NZVIYO+GlyphaLTStd-Bold Type 1C Custom yes yes yes 3145 0 SPFCQE+UniversLTStd-Cn Type 1C Custom yes yes yes 3146 0 RRJHCG+UniversLTStd-Bold Type 1C WinAnsi yes yes yes 3147 0 WZQGUW+UniversLTStd Type 1C Custom yes yes yes 3159 0 UHJFNA+GlyphaLTStd Type 1C Custom yes yes yes 462 0 JHJKZW+GlyphaLTStd-Light Type 1C WinAnsi yes yes yes 463 0 GlyphaLTStd-Bold2 Type 1C WinAnsi yes no yes 470 0 OWGQHM+Helvetica-Bold Type 1C WinAnsi yes yes no 474 0 NXWKTO+Helvetica Type 1C WinAnsi yes yes no 482 0 MTHEFQ+Helvetica-BoldOblique Type 1C WinAnsi yes yes no 475 0 LUSYRS+Helvetica-Oblique Type 1C WinAnsi yes yes no 483 0 LUSYRS+Symbol Type 1C Custom yes yes no 476 0 KQISDU+UniversLTStd-BoldCn Type 1C WinAnsi yes yes yes 481 0 GlyphaLTStd-Bold3 Type 1C WinAnsi yes no yes 493 0 GlyphaLTStd-Light2 Type 1C WinAnsi yes no yes 498 0 GlyphaLTStd-Bold4 Type 1C WinAnsi yes no yes 497 0 GlyphaLTStd-Bold5 Type 1C WinAnsi yes no yes 503 0 JHPHPW+UniversLTStd-CnObl Type 1C WinAnsi yes yes yes 507 0 YOFTRS+MinionPro-Regular Type 1C WinAnsi yes yes yes 505 0 WTECPW+UniversLTStd-Obl Type 1C WinAnsi yes yes yes 517 0 Helvetica2 Type 1C WinAnsi yes no no 523 0 Helvetica-Oblique2 Type 1C WinAnsi yes no no 519 0 CXCHVK+Helvetica-Bold2 Type 1C WinAnsi yes yes no 521 0 BTNBHM+SymbolMT Type 1C Custom yes yes no 522 0 Helvetica3 Type 1C WinAnsi yes no no 526 0 BTNBHM+Helvetica-Oblique3 Type 1C WinAnsi yes yes no 525 0 AUYVTO+Helvetica-Bold3 Type 1C WinAnsi yes yes no 524 0 AUYVTO+UniversLTStd-LightCn Type 1C Custom yes yes yes 531 0 WHVNPW+UniversLTStd-LightCnObl Type 1C WinAnsi yes yes yes 532 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-05-29 03:09:20 CEST RepresentationInformation: vdaf003.pdf ReportingModule: BYTESTREAM, Rel. 1.4 (2018-10-01) LastModified: 2026-05-28 16:05:18 CEST Size: 2054435 Format: bytestream Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/octet-stream Checksum: 5e5d74ae Type: CRC32 Checksum: d97a958fb2308679d76aae9fcc926fe1 Type: MD5 Checksum: 014b968beee81367c13de2d7baa3f412f700169a Type: SHA-1 Checksum: a0de94740316879aecac6746c5cafdb8584133d90a5ccda21cd977d0f24f38b9 Type: SHA-256