5638ee2b04dcf680f6672c6aae6d1388  41598_2025_Article_24714.pdf
02c733a64a583a3840f750ab2b64704ba6c916db  41598_2025_Article_24714.pdf
c8227bc8e6287166f75f01e9c0ab90adf9d67662008c1d321266f164af71f0a8  41598_2025_Article_24714.pdf

Creator:         Adobe InDesign 18.0 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Wed Oct 22 15:54:16 2025 CEST
ModDate:         Wed Nov 19 13:30:36 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           15
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       2761318 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ZNXCXP+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     29  0
DSPSWH+Wingdings-Regular             CID TrueType      Identity-H       yes yes yes   2021  0
TTLAMB+Corbel                        CID TrueType      Identity-H       yes yes yes     30  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     31  0
Corbel-Bold                          TrueType          WinAnsi          yes no  yes     33  0
Corbel                               TrueType          WinAnsi          yes no  yes     34  0
Corbel-Bold                          TrueType          WinAnsi          yes no  yes   2064  0
MinionPro-It                         Type 1C           Custom           yes no  yes     32  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes     46  0
MinionPro-BoldIt                     Type 1C           WinAnsi          yes no  yes     47  0
WVHVCV+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    221  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-06-06 04:33:12 CEST
 RepresentationInformation: 41598_2025_Article_24714.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-06-05 14:34:08 CEST
  Size: 2761318
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 2106
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Benchtop NMR urine metabolomics for diagnosing pulmonary tuberculosis
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Study population
         Item: 
          Title: Clinical characteristics and diagnostic testing
         Item: 
          Title: NMR analysis
         Item: 
          Title: Characterization of the TB metabolic fingerprint
         Item: 
          Title: Classification models
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Data and sample collection
         Item: 
          Title: Sample preparation for NMR analysis
         Item: 
          Title: NMR spectroscopy
         Item: 
          Title: NMR data processing
         Item: 
          Title: Data analysis
         Item: 
          Title: Metabolomic analysis
         Item: 
          Title: Comparison with FujiLAM assay
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.0 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Wed Oct 22 15:54:16 CEST 2025
    ModDate: Wed Nov 19 13:30:36 CET 2025
   ID: 0x2538815f64434b44b130e1bdcd9753af, 0x1e044ba81c07f0b51e018b0cee970b1d
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 991
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1845
      ImageHeight: 869
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1354
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1803
      ImageHeight: 1695
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: DSPSWH+Wingdings-Regular
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ZNXCXP+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TTLAMB+Corbel
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -318, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-BoldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-BoldIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -230, -360, 1684, 1032
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: Corbel-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel-Bold
       Flags: Nonsymbolic
       FontBBox: -556, -240, 1155, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Corbel
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WVHVCV+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: WVHVCV+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ZNXCXP+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZNXCXP+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -240, 1155, 952
       FontFile2: true
     Font: 
      BaseFont: DSPSWH+Wingdings-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: DSPSWH+Wingdings-Regular
       Flags: Symbolic
       FontBBox: 0, -211, 1359, 899
       FontFile2: true
     Font: 
      BaseFont: TTLAMB+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TTLAMB+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
      xmp:CreateDate="2025-10-22T15:54:16+02:00"
      xmp:MetadataDate="2025-11-19T13:30:36+01:00"
      xmp:ModifyDate="2025-11-19T13:30:36+01:00"
      xmp:CreatorTool="Adobe InDesign 18.0 (Windows)"
      xmpMM:InstanceID="uuid:33737a91-680f-4608-868a-d93b55161db5"
      xmpMM:OriginalDocumentID="xmp.did:7c83adf0-08c6-404b-bda7-72637a428208"
      xmpMM:DocumentID="xmp.id:51717916-b808-ae42-922c-e670d29e512e"
      xmpMM:RenditionClass="proof:pdf"
      xmpMM:VersionID="1"
      prism:aggregationType="journal"
      crossmark:DOI="10.1038/s41598-025-24714-0"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1038/s41598-025-24714-0"
      jav:journal_article_version="VoR"
      dc:format="application/pdf"
      pdf:Producer="Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Trapped="False"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <xmpMM:DerivedFrom
        stRef:instanceID="xmp.iid:0ea850fc-c8df-964a-8719-1811fabf408e"
        stRef:documentID="xmp.did:0836221c-187a-3446-8600-94291a081a26"
        stRef:renditionClass="default"/>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:parameters="from application/x-indesign to application/pdf"
            stEvt:softwareAgent="Adobe InDesign 18.0 (Windows)"
            stEvt:when="2025-10-22T15:54:16+02:00"/>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:345710f0-a820-4b56-a11e-53b52f4e9ff0"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-10-22T16:10:55+02:00"/>
        </rdf:Seq>
      </xmpMM:History>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 507, 265, 510, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 390, 769, 546, 758
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 481, 676, 556, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 704, 516, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 470, 674, 473, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 237, 614, 240, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 242, 614, 245, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 388, 594, 391, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 166, 554, 169, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 398, 524, 401, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 417, 504, 420, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 235, 484, 241, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 367, 474, 373, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 362, 312, 366, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 544, 222, 549, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 268, 162, 272, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 310, 72, 315, 60
       Flags: Print
       AppearanceDictionary: true
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 307, 118, 311, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 399, 88, 404, 76
       Flags: Print
       AppearanceDictionary: true
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 308, 275, 313, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 174, 215, 179, 203
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 181, 145, 185, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 446, 444, 451, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 489, 354, 493, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 273, 324, 277, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 407, 204, 412, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 500, 144, 504, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 275, 92, 281, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 283, 92, 289, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 136, 281, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 282, 136, 288, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 538, 136, 544, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 546, 136, 552, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 444, 68, 450, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 348, 704, 354, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 356, 704, 362, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 205, 684, 211, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 213, 684, 219, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 277, 644, 283, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 285, 644, 291, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 280, 584, 286, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 214, 574, 220, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 261, 564, 267, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 278, 554, 284, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 369, 494, 372, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 373, 494, 379, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 401, 484, 407, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 408, 484, 414, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 273, 474, 279, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 182, 434, 185, 422
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 297, 324, 300, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 302, 324, 305, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 513, 304, 516, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 213, 224, 219, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 406, 724, 409, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 316, 404, 319, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 339, 384, 342, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 254, 734, 260, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 505, 574, 511, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 310, 504, 316, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 318, 504, 324, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 386, 314, 392, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 393, 314, 399, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 724, 195, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 329, 714, 409, 702
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 714, 415, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 413, 674, 419, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 420, 674, 426, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 311, 604, 317, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 430, 584, 436, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 306, 564, 312, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 380, 544, 386, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 491, 404, 497, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 336, 314, 343, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 364, 164, 481, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 146, 421, 136
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 104, 297, 94
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 254, 88, 376, 78
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 80, 554, 69
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 71, 267, 61
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 190, 54, 322, 44
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 168, 725, 301, 715
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 230, 692, 362, 681
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 675, 285, 664
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 233, 658, 370, 648
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 641, 286, 631
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 281, 624, 421, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 545, 616, 554, 606
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 607, 332, 597
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 294, 591, 426, 580
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 197, 574, 329, 564
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 250, 557, 393, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 540, 418, 530
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 333, 524, 470, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 226, 507, 353, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 490, 420, 480
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 456, 519, 446
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 245, 440, 378, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 249, 423, 353, 412
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 190, 406, 322, 396
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 364, 554, 354
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 393, 339, 457, 328
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 276, 322, 385, 312
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 305, 372, 295
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 494, 478, 552, 466
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 468, 255, 456
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 476, 317, 554, 304
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 307, 261, 294
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 41, 770, 200, 758
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 7f19aa1e
   Type: CRC32
  Checksum: 5638ee2b04dcf680f6672c6aae6d1388
   Type: MD5
  Checksum: 02c733a64a583a3840f750ab2b64704ba6c916db
   Type: SHA-1
  Checksum: c8227bc8e6287166f75f01e9c0ab90adf9d67662008c1d321266f164af71f0a8
   Type: SHA-256