db7ac02f7f639f1e708cf5dcb76f988c biomolecules-15-00602.pdf 0a929ab92d3e3fa63dc2cfadac7e562a9e2aa69d biomolecules-15-00602.pdf bc346b5dde628bdaac5e4fdad390a611e52f058eda3790581153b77da63bcad8 biomolecules-15-00602.pdf Title: The Role of Antigen Carbohydrate 125 in Modulating Soluble ST2: Prognostic-Related Effects in Acute Heart Failure Subject: Background: Acute heart failure (AHF) is a complex syndrome associated with high mortality and hospital readmissions, characterized by volume overload and inflammation. Soluble ST2 (sST2) and antigen carbohydrate 125 (CA125) are emerging biomarkers that reflect these processes and may interact to influence long-term outcomes in AHF patients. This study aims to examine the prognostic relationship between sST2 and CA125 in predicting mortality and heart failure (HF)-related hospitalizations in patients with decompensated heart failure. Methods: In a cohort of 635 patients with AHF, we investigated whether the prognostic value of sST2 varies according to CA125 levels (35 vs. >35 U/mL). The endpoints were: (a) time to all-cause death, and (b) the combination of time to death or new HF admission. Results: This study of EAHFE registry data shows that the association between sST2 and long-term adverse outcomes (mortality and HF hospitalizations) in patients with AHF was differentially influenced by CA125 concentrations (p-value for interactions = 0.031 and 0.029, respectively). Higher sST2 was associated with the risk of death and the combined risk of death/HF readmission when CA125 was >35 U/mL [HR = 1.02 (CI 95%: 1.01–1.04), p = 0.006 and 1.02 (CI 95%: 1.01–1.03); p = 0.013 per increase in 10 ng/mL, respectively], but not when CA125 was 35 U/mL. Conclusions: This study highlights the prognostic interaction between sST2 and CA125 in AHF. Elevated sST2 predicts poor outcomes mainly in patients with high CA125 levels (>35 U/mL), suggesting CA125’s role in modulating inflammatory activity in HF. Further research is needed. Keywords: acute heart failure; CA125; sST2; inflammatory modulator Author: Arancha Martí-Martínez, Julio Núñez, Herminio López-Escribano, Elena Revuelta-López, Anna Mollar, Marta Peiró, Juan Sanchis, Antoni Bayés-Genís, Arturo Carratala, Òscar Miró, Pere Llorens and Pablo Herrero-Puente Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Apr 18 15:19:37 2025 CEST ModDate: Fri Apr 18 15:26:28 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3642112 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WWRBLZ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 BDNGZU+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 AIVALJ+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 LZSNFZ+URWPalladioL-Ital Type 1 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TrueType Identity-H yes yes yes 256 0 MEFDJP+PalatinoLinotype TrueType WinAnsi yes yes no 262 0 MEFDKB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 265 0 MEFDPD+PalatinoLinotype TrueType MacRoman yes yes no 268 0 MEFDJN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 287 0 MEFDJO+PalatinoLinotype CID TrueType Identity-H yes yes yes 290 0 MEFDJP+PalatinoLinotype TrueType WinAnsi yes yes no 296 0 MEFDKB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 299 0 MEFDPD+PalatinoLinotype TrueType MacRoman yes yes no 302 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-06-05 04:52:59 CEST RepresentationInformation: biomolecules-15-00602.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-06-04 15:03:20 CEST Size: 3642112 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 468 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Sample Destination: subsection.2.1 Item: Title: Biomarkers Assessment Destination: subsection.2.2 Item: Title: Endpoints Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Characteristics Destination: subsection.3.1 Item: Title: Baseline Characteristics Across CA125 and sST2 Categories Destination: subsection.3.2 Item: Title: Adverse Clinical Events Destination: subsection.3.3 Item: Title: Relationship Between CA125 and sST2 as Main Terms with Adverse Clinical Events Destination: subsection.3.4 Item: Title: The Modifying Prognostic Role of sST2 Across CA125 Destination: subsection.3.5 Children: Item: Title: All Cause-Death Destination: subsubsection.3.5.1 Item: Title: Combination of Death or New HF Admission Destination: subsubsection.3.5.2 Item: Title: Discussion Destination: section.4 Children: Item: Title: Structure and Pathophysiology of MUC16 (CA125) Destination: subsection.4.1 Item: Title: Relationship of CA125 with Pro-Inflammatory Pathways and sST2 Destination: subsection.4.2 Item: Title: Differential Effects of sST2 Across CA125 Levels Destination: subsection.4.3 Item: Title: Conclusions Destination: section.5 Item: Title: Appendix A Destination: appendix.A. Item: Title: References Destination: appendix.B. Info: Title: The Role of Antigen Carbohydrate 125 in Modulating Soluble ST2: Prognostic-Related Effects in Acute Heart Failure Author: Arancha Martí-Martínez, Julio Núñez, Herminio López-Escribano, Elena Revuelta-López, Anna Mollar, Marta Peiró, Juan Sanchis, Antoni Bayés-Genís, Arturo Carratala, Òscar Miró, Pere Llorens and Pablo Herrero-Puente Subject: Background: Acute heart failure (AHF) is a complex syndrome associated with high mortality and hospital readmissions, characterized by volume overload and inflammation. Soluble ST2 (sST2) and antigen carbohydrate 125 (CA125) are emerging biomarkers that reflect these processes and may interact to influence long-term outcomes in AHF patients. This study aims to examine the prognostic relationship between sST2 and CA125 in predicting mortality and heart failure (HF)-related hospitalizations in patients with decompensated heart failure. Methods: In a cohort of 635 patients with AHF, we investigated whether the prognostic value of sST2 varies according to CA125 levels (35 vs. >35 U/mL). The endpoints were: (a) time to all-cause death, and (b) the combination of time to death or new HF admission. Results: This study of EAHFE registry data shows that the association between sST2 and long-term adverse outcomes (mortality and HF hospitalizations) in patients with AHF was differentially influenced by CA125 concentrations (p-value for interactions = 0.031 and 0.029, respectively). Higher sST2 was associated with the risk of death and the combined risk of death/HF readmission when CA125 was >35 U/mL [HR = 1.02 (CI 95%: 1.01 1.04), p = 0.006 and 1.02 (CI 95%: 1.01 1.03); p = 0.013 per increase in 10 ng/mL, respectively], but not when CA125 was 35 U/mL. Conclusions: This study highlights the prognostic interaction between sST2 and CA125 in AHF. Elevated sST2 predicts poor outcomes mainly in patients with high CA125 levels (>35 U/mL), suggesting CA125’s role in modulating inflammatory activity in HF. Further research is needed. 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