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Profile: Linearized PDF PDFMetadata: Objects: 938 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Outline placeholder Destination: unknown Children: Item: Title: Highlights Destination: head_4_1656822 Item: Title: Extracellular histones are key mediators in the pathophysiology of critical illnesses Destination: head_5_2145350 Children: Item: Title: The role of extracellular histones in sepsis and septic shock Destination: head_6_2314050 Item: Title: The role of extracellular histones in SARS-CoV2-induced viral sepsis Destination: head_7_274040 Item: Title: Extracellular histones mediate cell cytotoxicity and contribute to multiorgan failure Destination: head_8_1683816 Children: Item: Title: Extracellular histones cause severe damage in endothelium Destination: head_9_2316442 Item: Title: Extracellular histones induce myocardial dysfunction Destination: head_10_2149492 Item: Title: Extracellular histones contribute to acute lung injury Destination: head_11_757717 Item: Title: The role of extracellular histones in pancreatitis Destination: head_12_1601218 Item: Title: Extracellular histones contribute to acute kidney injury Destination: head_13_926417 Item: Title: Circulating histones are potential biomarkers for critically ill patient management Destination: head_14_1137292 Children: Item: Title: Blood circulating histones as biomarkers for conditions of severe illness Destination: head_15_1643393 Item: Title: Blood circulating histones as biomarkers in viral sepsis induced by SARS-CoV2 infection Destination: head_16_274040 Item: Title: Quantitative proteomic tools could measure circulating histones as biomarkers of severe conditions Destination: head_17_1536867 Item: Title: Potential clinical implications of circulating histones as targets in septic patient management Destination: head_18_673367 Item: Title: Conclusions and perspectives Destination: head_19_2149492 Item: Title: Acknowledgements 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