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Title:           Maintaining kidney health in aging societies: a JSN and ERA call to action
Subject:         DOI: 10.1093/ndt/gfaf068 Nephrology Dialysis Transplantation, 40, 8, 10-04-2025. Abstract: Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular–kidney–metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.
Keywords:        aging, chronic kidney disease, gerosuppression, kidney aging, kidney replacement therapy
Author:          Ortiz Alberto, Kramer Anneke, Rychlík Ivan, Nangaku Masaomi, Yanagita Motoko, Jager Kitty J., Caskey Fergus J., Stel Vianda S., Kashihara Naoki, Kuragano Takahiro, Suzuki Yusuke, Takemoto Yoshiaki, Yokoi Hideki, Palladino Giuseppe, Fliser Danilo, Torra Roser, Wanner Christoph
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      Title: KIDNEY DISEASE BURDEN IN AN AGING WORLD
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      Title: BIOLOGICAL AGING AS A TREATABLE CONDITION: KIDNEYS AS GEROSUPPRESSORS
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      Title: KIDNEY CARE IN AN AGING SOCIETY
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        Title: Maintaining kidney health: biological kidney aging as a preventable condition
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        Title: Kidney failure management in the elderly
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      Title: CALL TO ACTION
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        Title: Box JSN and ERA call to action: Achieving Kidney Health in Aging/Aged Societies
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    Author: Ortiz Alberto, Kramer Anneke, Rychlík Ivan, Nangaku Masaomi, Yanagita Motoko, Jager Kitty J., Caskey Fergus J., Stel Vianda S., Kashihara Naoki, Kuragano Takahiro, Suzuki Yusuke, Takemoto Yoshiaki, Yokoi Hideki, Palladino Giuseppe, Fliser Danilo, Torra Roser, Wanner Christoph
    Subject: DOI: 10.1093/ndt/gfaf068 Nephrology Dialysis Transplantation, 40, 8, 10-04-2025. Abstract: Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular–kidney–metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.
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   Type: CRC32
  Checksum: 8555d66b06e6194edd546f6f39ad68d6
   Type: MD5
  Checksum: 4b16137f40a1e00b355ef347d190e4e8c4e3f4c2
   Type: SHA-1
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   Type: SHA-256