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Title:           Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
Subject:         Oncogene, doi:10.1038/s41388-025-03339-7
Keywords:        
Author:          Kimberley McGrail
Creator:         Springer
CreationDate:    Fri May 16 08:04:54 2025 CEST
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Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-06-24 04:09:11 CEST
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     Item: 
      Title: Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
      Destination: title_link
      Children: 
       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: A single dose of UVR prevents BRAFV600E-induced cell arrest and/or senescence in neonatal mice
          Destination: B1
         Item: 
          Title: Gene expression profiling confirmed the role of UVB radiation in preventing oncogenic BRAFV600E-induced growth arrest
          Destination: B2
         Item: 
          Title: Loss of Lkb1 prevents BRAFV600E-induced growth arrest
          Destination: B3
         Item: 
          Title: Upregulation of BNC1, KIF14, NCKAP5, PHGDH, PRKG2 and UPP1 is observed during melanoma progression
          Destination: B4
         Item: 
          Title: Upregulation of BNC1, CHTF18, KIF14, NCKAP5, and UPP1 is associated with melanoma and oncogene-driven cancers
          Destination: B5
         Item: 
          Title: UPP1, CHTF18, and BNC1 promote the transformation of BRAFV600E-mutated melanoma cells toward a neural crest-like phenotype
          Destination: B6
         Item: 
          Title: Targeting UPP1 effectively suppresses BRAFV600E mutant tumor growth in vivo
          Destination: B7
       Item: 
        Title: Discussion
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       Item: 
        Title: Materials and methods
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        Children: 
         Item: 
          Title: Materials availability
          Destination: B8
         Item: 
          Title: Reagents
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         Item: 
          Title: Mouse model
          Destination: B10
         Item: 
          Title: Melanoma initiation in vivo
          Destination: B11
         Item: 
          Title: Primary melanocyte culture
          Destination: B12
         Item: 
          Title: Cell lines and treatments
          Destination: B13
         Item: 
          Title: Human melanoma samples
          Destination: B14
         Item: 
          Title: Molecular cloning
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         Item: 
          Title: Lentiviral transduction: overexpression and shRNA-mediated gene knockdown
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         Item: 
          Title: Chromogenic assay for β-galactosidase activity
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         Item: 
          Title: Immunocytochemical (IC), immunofluorescence (IF), and immunohistochemical (IHC) analyses
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         Item: 
          Title: Protein isolation and western blotting
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         Item: 
          Title: RNA Isolation, quantification, and quality control
          Destination: B20
         Item: 
          Title: Microarray analysis
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         Item: 
          Title: Quantitative reverse transcription (RT)‒PCR
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         Item: 
          Title: Single-cell RNA sequencing (scRNA-seq) and data analysis
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         Item: 
          Title: In vivo tumor growth
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         Item: 
          Title: Statistical analysis
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          Children: 
           Item: 
            Title: Senescence signature establishment
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       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
        Destination: A7
       Item: 
        Title: Competing interests
        Destination: A8
       Item: 
        Title: ADDITIONAL INFORMATION
        Destination: M1
   Info: 
    Title: Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
    Author: Kimberley McGrail
    Subject: Oncogene, doi:10.1038/s41388-025-03339-7
    Keywords: 
    Creator: Springer
    CreationDate: Fri May 16 08:34:54 CEST 2025
    ModDate: Fri May 16 08:51:01 CEST 2025
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   Type: CRC32
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