3bcf559589b8610c04e75250eff0196b 328730.pdf c6a1243d3d8f7a6ef2a65fe8558fa1bc2d22d5a9 328730.pdf 45efc75485c0671920cec323f4469f4ce6a743c615b0e1090f2445e41ef0f5f8 328730.pdf Title: The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts Subject: Alzheimer's & Dementia 2025.21:e70804 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri Nov 7 11:58:30 2025 CET ModDate: Wed May 27 12:58:50 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 370712 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PNCKLH+Lato-Regular Type 1C WinAnsi yes yes no 50 0 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valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The association of diabetes with Alzheimer’s disease biomarkers and vascular burden across European aging and memory clinic cohorts Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Participants Destination: subsection..1.2.1 Item: Title: 2.2 | Clinical assessment Destination: subsection..1.2.2 Item: Title: 2.3 | Assessment of AD biomarkers and vascular burden Destination: subsection..1.2.3 Children: Item: Title: 2.3.1 | CSF measures Destination: subsubsection..1.2.3.1 Item: Title: 2.3.2 | PET measures Destination: subsubsection..1.2.3.2 Item: Title: 2.3.3 | MRI measures Destination: subsubsection..1.2.3.3 Item: Title: 2.4 | APOE ε4 carriership Destination: subsection..1.2.4 Item: Title: 2.5 | Profiles of Ab with other AD and vascular burden markers Destination: subsection..1.2.5 Item: Title: 2.6 | Statistical analyses Destination: subsection..1.2.6 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Demographics Destination: subsection..1.3.1 Item: Title: 3.2 | Associations of DM with AD biomarkers and vascular burden Destination: subsection..1.3.2 Item: Title: 3.3 | Associations of DM with profiles of Ab in combination with tau, MTA, and vascular burden markers Destination: subsection..1.3.3 Item: Title: 3.4 | Sensitivity analyses Destination: subsection..1.3.4 Item: Title: 4 | DISCUSSION Destination: section..1.4 Children: Item: Title: 4.1 | Strengths and limitations Destination: subsection..1.4.1 Item: Title: 5 | CONCLUSIONS AND FUTURE DIRECTIONS Destination: section..1.5 Item: Title: AFFILIATIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Item: Title: CONSENT STATEMENT Destination: section*.10 Item: Title: ORCID Destination: section*.12 Item: Title: REFERENCES Destination: section*.14 Item: Title: SUPPORTING INFORMATION Destination: section*.16 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1505 ImageHeight: 722 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: PNDDOE+Lato-BoldItalic FontSubset: true FirstChar: 65 LastChar: 112 FontDescriptor: FontName: 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