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Destination: HeadingBPH_70051bph70051-sec-0006 Item: Title: What does this study add? Destination: HeadingBPH_70051bph70051-sec-0007 Item: Title: What is the clinical significance? Destination: HeadingBPH_70051bph70051-sec-0008 Children: Item: Title: 2.3 | DNA extraction Destination: HeadingBPH_70051bph70051-sec-0013 Item: Title: 2.4 | Whole exome sequencing Destination: HeadingBPH_70051bph70051-sec-0014 Item: Title: 2.5 | Variants in reported toxicity genes Destination: HeadingBPH_70051bph70051-sec-0015 Children: Item: Title: 2.5.1 | Variants described in the literature Destination: HeadingBPH_70051bph70051-sec-0016 Item: Title: 2.5.2 | Novel variants in reported genes Destination: HeadingBPH_70051bph70051-sec-0017 Item: Title: 2.6 | Discovery of novel rare toxicity variants/genes Destination: HeadingBPH_70051bph70051-sec-0018 Children: Item: Title: 2.6.1 | Gene‐based tests Destination: HeadingBPH_70051bph70051-sec-0019 Item: Title: 2.7 | Genome‐Wide Association Studies (GWAS) meta‐analyses Destination: HeadingBPH_70051bph70051-sec-0020 Item: Title: 2.8 | Materials Destination: HeadingBPH_70051bph70051-sec-0021 Item: Title: 2.9 | Nomenclature of targets and ligands Destination: HeadingBPH_70051bph70051-sec-0022 Item: Title: 3 | RESULTS Destination: HeadingBPH_70051bph70051-sec-0023 Children: Item: Title: 3.1 | Variants in reported toxicity genes Destination: HeadingBPH_70051bph70051-sec-0024 Children: Item: Title: 3.1.1 | Variants described in the literature Destination: HeadingBPH_70051bph70051-sec-0025 Item: Title: 3.1.2 | Novel variants in reported genes Destination: HeadingBPH_70051bph70051-sec-0026 Item: Title: 3.2 | Discovery of novel rare toxicity variants/genes Destination: HeadingBPH_70051bph70051-sec-0027 Children: Item: Title: 3.2.1 | Gene‐based tests Destination: HeadingBPH_70051bph70051-sec-0028 Item: Title: 3.3 | Global toxicity genome‐wide association studies (GWAS) meta‐analyses Destination: HeadingBPH_70051bph70051-sec-0029 Item: Title: 4 | DISCUSSION Destination: HeadingBPH_70051bph70051-sec-0030 Item: Title: 5 | CONCLUSIONS Destination: HeadingBPH_70051bph70051-sec-0031 Item: Title: AUTHOR CONTRIBUTIONS Destination: 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application/pdfdoi:10.1111/bph.70051 10.1111/bph.70051https://doi.org/10.1111/bph.70051 2025-07-07truebpspubs.onlinelibrary.wiley.com10.1111/bph.70051 bpspubs.onlinelibrary.wiley.comtrue10.1111/bph.700512025-07-07 VoR Pages: Page: Label: 5340 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 131, 592, 133, 604 Destination: null Annotation: Subtype: Link Rect: 131, 597, 138, 610 Destination: null Annotation: Subtype: Link Rect: 140, 596, 149, 604 Annotation: Subtype: Link Rect: 291, 592, 292, 604 Destination: null Annotation: Subtype: Link Rect: 291, 597, 297, 610 Destination: null Annotation: Subtype: Link Rect: 496, 592, 497, 604 Destination: null Annotation: Subtype: Link Rect: 496, 597, 502, 610 Destination: null Annotation: Subtype: Link Rect: 119, 574, 120, 586 Destination: null Annotation: Subtype: Link Rect: 119, 579, 126, 591 Destination: null Annotation: Subtype: Link Rect: 278, 574, 279, 586 Destination: null Annotation: Subtype: Link Rect: 278, 579, 284, 591 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