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Introduction Destination: flink2 Children: Item: Title: 1.1. An urgent need for a computable information infrastructure Destination: slink1 Item: Title: 1.2. The importance of data standards Destination: slink2 Item: Title: 1.3. GRADE as a de facto data standard Destination: slink3 Item: Title: 2. The GRADE ontology Destination: flink3 Children: Item: Title: 2.1. Potential benefits of the GRADE Ontology Destination: slink4 Children: Item: Title: 2.1.1. Benefits to the creators and users of systematic reviews and guidelines, including educators and learners Destination: tlink1 Item: Title: 2.1.2. Benefits to tool developers Destination: tlink2 Item: Title: 2.2. Development and maintenance of the GRADE Ontology Destination: slink5 Children: Item: Title: 2.2.1. Team and governance Destination: tlink3 Item: Title: 2.2.2. Scope Destination: tlink4 Item: Title: 2.2.3. Specifying preferred terms, definitions, and comments for application Destination: tlink5 Item: Title: 2.2.4. Publication and dissemination Destination: tlink6 Item: Title: 2.2.5. User testing and support for implementation Destination: tlink7 Item: Title: 2.2.6. Maintenance and development Destination: tlink8 Item: Title: 3. Conclusion Destination: flink4 Item: Title: Declaration of generative AI and AI-assisted technologies in the writing process Destination: flink5 Item: Title: CRediT authorship contribution statement Destination: flink6 Item: Title: Declaration of competing interest Destination: aclink2 Item: Title: Acknowledgments Destination: flink7 Item: Title: References Destination: biblink7 Info: Title: GRADE concept paper 9: rationale and process for creating a GRADE Ontology Author: Paul Whaley Subject: Journal of Clinical Epidemiology, 187 (2025) 111921. doi:10.1016/j.jclinepi.2025.111921 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Wed Nov 12 04:16:23 CET 2025 ModDate: Wed Nov 12 04:20:18 CET 2025 ID: 0x4f66edc8837dbc79397153a95f94d5e0, 0xf5b777792a8eda4096eac3f52ffa0ba6 Filters: FilterPipeline: FlateDecode FilterPipeline: CCITTFaxDecode Images: Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 749 ImageHeight: 827 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Decode: 1, 0 Fonts: Type0: Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Font: BaseFont: RBHGNZ+ArialUnicodeMS Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: SAXPSF+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: SAXPSF+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: XSUWHL+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: XSUWHL+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SZYVHC+ESSTIX-Five FontSubset: true FirstChar: 33 LastChar: 116 FontDescriptor: FontName: SZYVHC+ESSTIX-Five Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IOVZVT+Times-Roman FontSubset: true FirstChar: 33 LastChar: 251 FontDescriptor: FontName: IOVZVT+Times-Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: DPIXDV+TradeGothic FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: DPIXDV+TradeGothic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IBAJKH+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: IBAJKH+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: KEGOEY+Times-Italic FontSubset: true FirstChar: 33 LastChar: 251 FontDescriptor: FontName: KEGOEY+Times-Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: DABFBQ+Times-BoldItalic FontSubset: true FirstChar: 33 LastChar: 251 FontDescriptor: FontName: DABFBQ+Times-BoldItalic Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: OWDSZR+Times-Bold FontSubset: true FirstChar: 33 LastChar: 251 FontDescriptor: FontName: OWDSZR+Times-Bold Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: FGPRQW+TradeGothic-Bold FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: FGPRQW+TradeGothic-Bold Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: RBHGNZ+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RBHGNZ+ArialUnicodeMS Flags: Nonsymbolic FontBBox: -1011, -279, 2260, 1074 FontFile2: true Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true XMP: application/pdf doi:10.1016/j.jclinepi.2025.111921 GRADE concept paper 9: rationale and process for creating a GRADE Ontology Paul Whaley Brian Alper Joanne Dehnbostel Carlos Alva-Diaz Stavros Antoniou Antonio Bognanni Javier Bracchiglione Therese Kristine Dalsbø Sean Grant Jennifer Hunter Alfonso Iorio Malgorzata Lagisz Harold Lehmann Sheyu Li Joerg Meerpohl Saphia Mokrane Cauê Monaco Ignacio Neumann Kevin Pottie Shahab Sayfi Nigar Sekercioglu Jasvinder Singh Bernardo Sousa-Pinto Janice Tufte Lenny Thinagaran Vasanthan Li Wang Jun Xia Xiaomei Yao Holger Schünemann GRADE approach Certainty of evidence Evidence-to-decisions Ontology Data standards Journal of Clinical Epidemiology, 187 (2025) 111921. doi:10.1016/j.jclinepi.2025.111921 The Authors journal Journal of Clinical Epidemiology © 2025 The Authors. 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