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Title:           Precision targeting of CXCR4+ leukemia cells by a humanized MMAE-nanoconjugate in an AML mouse model
Subject:         Biomedicine & Pharmacotherapy, 192 (2025) 118573. doi:10.1016/j.biopha.2025.118573
Keywords:        Acute myeloid leukemia,CXCR4,Humanized nanoconjugate,MMAE,Targeted therapy
Author:          Annabel Garcia-León
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      Title: Precision targeting of CXCR4+ leukemia cells by a humanized MMAE-nanoconjugate in an AML mouse model
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       Item: 
        Title: 1 Introduction
        Destination: mk:H1_1
       Item: 
        Title: 2 Materials and methods
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        Children: 
         Item: 
          Title: 2.1 T22-HSNBT-H6 nanocarrier design
          Destination: mk:H2_1
         Item: 
          Title: 2.2 T22-HSNBT-H6 protein production and purification
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         Item: 
          Title: 2.3 Site-directed cysteine-coupling of MMAE to T22-HSNBT-H6
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         Item: 
          Title: 2.4 Cultivation and maintenance of AML cell lines and patient samples
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         Item: 
          Title: 2.5 Assessment of CXCR4 membrane levels in AML cell lines, PBMCs and patient samples
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         Item: 
          Title: 2.6 Analysis of T22-HSNBT-H6-MMAE antineoplastic effect in AML cell lines, PBMCs and cultured AML patients’ BM cells
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         Item: 
          Title: 2.7 Apoptosis assessment
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         Item: 
          Title: 2.8 Cell cycle assay
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         Item: 
          Title: 2.9 Animal maintenance
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         Item: 
          Title: 2.10 Evaluation of T22-HSNBT-H6-MMAE antineoplastic effect in a CXCR4+ AML disseminated mouse model
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         Item: 
          Title: 2.11 Detection of THP-1-Luci cells in bone marrow
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         Item: 
          Title: 2.12 Immunohistochemical staining of leukemic cells in AML-infiltrated organs
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         Item: 
          Title: 2.13 Toxicity analysis in tissues and blood
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         Item: 
          Title: 2.14 Statistical analysis
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       Item: 
        Title: 3 Results
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         Item: 
          Title: 3.1 CXCR4-targeted humanized nanoconjugate structure and characterization
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         Item: 
          Title: 3.2 Cytotoxic effect of T22-HSNBT-H6-MMAE nanoconjugate targeting CXCR4+ AML cells
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          Title: 3.3 Mitotic catastrophe followed by apoptosis induced by T22-HSNBT-H6-MMAE
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          Title: 3.4 T22-HSNBT-H6-MMAE blocks leukemic proliferation and enhances survival in an AML mouse model
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         Item: 
          Title: 3.5 Immunohistochemical assessment of leukemia dissemination inhibition following T22-HSNBT-H6-MMAE treatment
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         Item: 
          Title: 3.6 Histopathological and hematological toxicity evaluation of T22-HSNBT-H6-MMAE
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         Item: 
          Title: 3.7 Reduction of leukemia burden by T22-HSNBT-H6-MMAE in AML model with high leukemic infiltration
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         Item: 
          Title: 3.8 Cytotoxic effect of T22-HSNBT-H6-MMAE nanoconjugate on CXCR4+ AML patient cells
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       Item: 
        Title: 4 Discussion
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       Item: 
        Title: CRediT authorship contribution statement
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       Item: 
        Title: Funding
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       Item: 
        Title: Declaration of Competing Interest
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Appendix A Supporting information
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       Item: 
        Title: Data availability
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        Title: References
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  Checksum: 7c5175cbd67ef9e71178cedeb9745add
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