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Title:           A versatile plug and play bacterial chassis based on a fast-growing Mycoplasma species
Subject:         DOI: 10.1093/nar/gkaf1134 Nucleic Acids Research, 53, 20, 00-00-2025. Abstract: An easy engineerable bacterial chassis opens a spectrum of biomedical applications such as antigen or drug delivery. However, most cell-walled bacteria are readily recognized and cleared by the immune system and encode various effector proteins potentially interacting with the target species. Mycoplasma feriruminatoris, a cell-wall-less minimal organism with excellent growth attributes, was genetically engineered to stably and almost seamlessly incorporate foreign DNA fragments into the chromosome in a single step using an orthogonal recombinase system. Using this mechanism, we characterized and developed promoters and proved their functionality, including a kill-switch based on a temperature-sensitive promoter that drives expression of a toxin from a toxin–antitoxin system. Additionally, we designed a streptavidin-based functional dynamic display system at the surface of the bacterium. The engineered strains have great potential such as to deliver vaccine antigens to different livestock species among other biomedical applications.
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   Type: CRC32
  Checksum: d5fcbdd380a782432c307835bf5a372e
   Type: MD5
  Checksum: 73658e8bf1e1580b722c555d967f8a648eea2dde
   Type: SHA-1
  Checksum: dfe5882a44b3c63ba6b9e15b4e78a47ef75e295d752f0fd00d5eab19aafd47df
   Type: SHA-256