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Title:           Nanotoxin induces in situ pyroptosis to sensitize αPD1 to ablate metastases in microsattellite stable colorectal cancer
Subject:         Pharmacological Research, 221 (2025) 107982. doi:10.1016/j.phrs.2025.107982
Keywords:        Targeted nanotoxin,In situ release,Pyroptosis,T cell recruitment,Antimetastatic effect,Immuno-oncology
Author:          Luis M. Carrasco-Díaz
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      Title: Nanotoxin induces in situ pyroptosis to sensitize αPD1 to ablate metastases in microsattellite stable colorectal cancer
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Nanotoxin
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          Title: 2.2 Cell lines and cell culture
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          Title: 2.3 In vivo experiments
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          Title: 2.4 Sample processing for hematoxylin and eosin (H&E), DAPI and immunohistochemical (IHC) staining to evaluate the molecula ...
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          Title: 2.5 Plasma and blood analysis
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          Title: 2.6 Cell viability assays
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         Item: 
          Title: 2.7 Western blot
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          Title: 2.8 Statistical analyses
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        Title: 3 Results
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         Item: 
          Title: 3.1 TDX induces ‘in situ’ pyroptosis and local CD8 T cell recruitment in targeted tumor tissues, whereas its combination wi ...
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         Item: 
          Title: 3.2 TDX induces in situ pyroptosis and local CD8 T cell recruitment in targeted metastatic tissues
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          Title: 3.3 Sequential TDX+ αPD1 combination induces cancer cell killing associated with CD8 T cell activation and IFNγ and Perfori ...
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          Title: 3.4 TDX+ αPD1 induces antimetastatic in MSS mesentery and peritoneum associated with CD8 T cell activation and IFNγ secretion
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         Item: 
          Title: 3.5 TDX ​+ αPD1 induces a synergistic effect in MSS liver and lung metastases, whereas the liver effect associates with CD8 ...
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          Title: 3.6 TDX+ αPD1 combination induces potent antimetastic effect without systemic toxicity
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        Title: 4 Discussion
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         Item: 
          Title: 4.1 TDX nanotoxin-mediated pyroptosis recruits and activates CD8 T cells to induce immunogenic cell death and anticancer effect
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          Title: 4.2 TDX sensitizes to αPD1 to achieve a remarkably synergistic effect in liver metastases when administered as the TDX+ αPD ...
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          Title: 4.3 TDX sensitizes to αPD1 achieving tissue-specific responses, CD8 T cell recruitment, and secretion of cytokine or cytoto ...
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          Title: 4.4 Toxicity associated to TDX+ αPD1
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          Title: 4.5 Immunotherapy in clinical trials for MSS mCRC
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         Item: 
          Title: 4.6 Suggested mechanism of sensitization by TDX to the ICI αPD1 that mimicks the response to infection by diphtheria
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        Title: 5 Conclusions
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        Title: CRediT authorship contribution statement
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        Title: Ethics approval and consent to participate
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        Title: Consent for publication
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        Title: Funding
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       Item: 
        Title: Declaration of Competing Interest
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       Item: 
        Title: Acknowledgments
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        Title: Appendix A Supporting information
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       Item: 
        Title: Data availability
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        Title: References
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    Title: Nanotoxin induces in situ pyroptosis to sensitize αPD1 to ablate metastases in microsattellite stable colorectal cancer
    Author: Luis M. Carrasco-Díaz
    Subject: Pharmacological Research, 221 (2025) 107982. doi:10.1016/j.phrs.2025.107982
    Keywords: Targeted nanotoxin,In situ release,Pyroptosis,T cell recruitment,Antimetastatic effect,Immuno-oncology
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   Type: CRC32
  Checksum: c121dac1ec5f400a896e620eb65ec786
   Type: MD5
  Checksum: 32f40e2f072b2ff2bba9681f0e0c6cdc34408393
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