c21f80dc4d19f4fc4f4949ac9c86e485  JouExp_a2025v76n15p4340.pdf
203d524a445d303aa7f6a86126b80d5271da642e  JouExp_a2025v76n15p4340.pdf
2ea3aa06d0885dd0809eb7c8a28813e60ab399d07ef00d07700dcf2dd1b0fd3b  JouExp_a2025v76n15p4340.pdf

Title:           The CAPE1 peptide confers resistance against bacterial wilt in tomato
Subject:         DOI: 10.1093/jxb/eraf145
Journal of Experimental Botany, Volume. XX, Issue. XX, 3 April 2025
Abstract 
Bacterial wilt caused by Ralstonia solanacearum is one of the most destructive bacterial diseases for which no effective treatment exists. There is an urgent need to understand the basis of resistance against this pathogen in order to engineer efficient strategies in the field. We previously demonstrated that resistant tomato plants limit bacterial movement in the apoplast and the xylem. As a first step to dissect the underlying mechanisms, we analysed the apoplast proteome upon challenge with R. solanacearum in the susceptible tomato cultivar Marmande and the resistant cultivar Hawaii 7996. Here, we described the xylem proteome in these same cultivars and compared it with the apoplastic proteome, revealing variety-dependent and infection-dependent changes. This proteomic analysis led to the identification of pathogenesis-related 1 (PR1) proteins as highly induced upon infection. Since PR1b was the most abundant PR1 protein in both the apoplast and the xylem, we concentrated on this family member to study the role of PR1s in the interaction between tomato and R. solanacearum. Surprisingly, lack of PR1b resulted in enhanced resistance to R. solanacearum in tomato, which could be due to an up-regulation of homologous genes in a compensatory effect as has been reported before. PR1 processing by an unknown protease in tomato results in the generation of the CAPE peptide. Treatment of tomato plants with the CAPE1 peptide resulted in restriction of R. solanacearum growth, via defence gene reprogramming. Future work in the lab will help determine which tomato secreted proteases cleave PR1s to generate CAPEs.
Author:          Weiqi Zhang,Marc Planas-Marquès,Moyan Liang,Qingshan Zhang,Annemarie Vermeulen,Farnusch Kaschani,Markus Kaiser,Frank L. W. Takken,Nuria S. Coll,Marc Valls
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iTextSharp.LGPLv2.Core 3.7.4.0
CreationDate:    Sat May 10 11:26:47 2025 CEST
ModDate:         Wed Jul 15 17:46:17 2026 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           19
Encrypted:       no
Page size:       612.283 x 790.866 pts
Page rot:        0
File size:       6567072 bytes
Optimized:       no
PDF version:     1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HLHWMP+HelveticaNeueLTStd-Lt         Type 1C           Custom           yes yes yes   2100  0
WGYAHF+Helvetica-LightOblique        Type 1C           Custom           yes yes no    2101  0
NHWDKX+HelveticaNeueLTStd-LtIt       Type 1C           WinAnsi          yes yes yes   2102  0
NHWDKX+HelveticaNeueLTStd-LtIt       Type 1C           Custom           yes yes yes     65  0
HLHWMP+HelveticaNeueLTStd-Lt         Type 1C           Custom           yes yes yes     55  0
MIJLMA+HelveticaNeueLTStd-Md         Type 1C           WinAnsi          yes yes yes   2103  0
ALFMAY+HelveticaNeueLTStd-Bd         Type 1C           Custom           yes yes yes     56  0
ZSNWMA+MyriadPro-Bold                Type 1C           Custom           yes yes yes    203  0
DTMPQS+MyriadPro-Light               Type 1C           Custom           yes yes yes     86  0
HHINUK+HelveticaNeueLTStd-BdIt       Type 1C           WinAnsi          yes yes yes    198  0
FIKMSO+ArialMT                       TrueType          WinAnsi          yes yes no       1  0
BZLTYW+BemboStd                      Type 1C           WinAnsi          yes yes yes   2136  0
QTJGUG+HelveticaNeueLTStd-Bd         Type 1C           Custom           yes yes yes     53  0
HLHWMP+HelveticaNeueLTStd-Lt         Type 1C           Custom           yes yes yes     54  0
BemboStd2                            Type 1C           Custom           yes no  yes     57  0
PWIECU+BemboStd-Italic               Type 1C           WinAnsi          yes yes yes     58  0
GBOXGM+GandhariUnicode-Roman         Type 1C           Custom           yes yes yes     59  0
BemboStd3                            Type 1C           WinAnsi          yes no  yes    628  0
HLHWMP+HelveticaNeueLTStd-Lt         Type 1C           Custom           yes yes yes     64  0
BemboStd4                            Type 1C           WinAnsi          yes no  yes    630  0
SBQMSO+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      84  0
SBQMSO+Arial-BoldMT2                 Type 1C           WinAnsi          yes yes no      85  0
SBQMSO+ArnoPro-Regular               Type 1C           Custom           yes yes yes     94  0
YXQWYC+Arial-BoldItalicMT            Type 1C           WinAnsi          yes yes no      99  0
AAPIAY+Arial-BoldMT3                 Type 1C           WinAnsi          yes yes no     100  0
AAPIAY+Arial-ItalicMT                Type 1C           WinAnsi          yes yes no     101  0
AAPIAY+ArialMT                       Type 1C           WinAnsi          yes yes no     102  0
ArialMT2                             Type 1C           WinAnsi          yes no  no     103  0
Arial-BoldItalicMT2                  Type 1C           WinAnsi          yes no  no     104  0
Arial-BoldMT4                        Type 1C           WinAnsi          yes no  no     105  0
YXQWYC+ArialMT3                      Type 1C           WinAnsi          yes yes no     106  0
YXQWYC+Arial-BoldMT5                 Type 1C           WinAnsi          yes yes no     146  0
Arial-BoldMT6                        Type 1C           WinAnsi          yes no  no     147  0
ArialMT4                             Type 1C           WinAnsi          yes no  no     148  0
XTBQKE+Arial-ItalicMT2               Type 1C           WinAnsi          yes yes no     149  0
XTBQKE+SymbolMT                      Type 1C           Custom           yes yes no     150  0
XTBQKE+Arial-BoldMT7                 Type 1C           WinAnsi          yes yes no     151  0
XTBQKE+Aptos-Bold                    Type 1C           WinAnsi          yes yes no     152  0
WUMKWG+Arimo-Bold                    CID TrueType      Identity-H       yes yes yes    202  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-07-16 04:23:47 CEST
 RepresentationInformation: JouExp_a2025v76n15p4340.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-07-15 17:47:30 CEST
  Size: 6567072
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 2157
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-US
    Outlines: 
     Item: 
      Title: The CAPE1 peptide confers resistance against bacterial wilt in tomato
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Plant material and growth conditions
         Item: 
          Title: Bacterial material, plant inoculations, and pathogenicity assays
         Item: 
          Title: Xylem sap collection, pooling, and concentration
         Item: 
          Title: Proteomic analyses
          Children: 
           Item: 
            Title: Sample clean-up for liquid chromatography–mass spectrometry
           Item: 
            Title: Liquid chromatography–tandem mass spectrometry
           Item: 
            Title: Peptide and protein identification
         Item: 
          Title: Sequence comparison and phylogenetic analyses of PR1 proteins
         Item: 
          Title: Cloning of the PR1 proteins
         Item: 
          Title: Transient expression PR1 proteins in Nicotiana benthamiana
         Item: 
          Title: Generation of stable PR1b overexpression tomato plants
         Item: 
          Title: Purification of PR1b proteins and derivatives
         Item: 
          Title: Generation of CRISPR/Cas9 pr1b mutant tomato plants
         Item: 
          Title: Extraction of apoplast and total extract from tomato leaves and N. benthamiana leaves
         Item: 
          Title: Confocal microscopy
         Item: 
          Title: Treatment plants with CAPE1 peptide
         Item: 
          Title: Antimicrobial assay in vitro
         Item: 
          Title: RNA extraction and quantitative reverse transcription–PCR analysis
         Item: 
          Title: Statistical analyses
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Xylem sap and apoplast proteomes reveal high accumulation of PR1 proteins upon R. solanacearum infection
         Item: 
          Title: Characterization of the tomato PR1 family and its conservation
         Item: 
          Title: PR1b involvement in tomato defence
         Item: 
          Title: Role of the CAPE1 peptide in response to R. solanacearum
       Item: 
        Title: Discussion
       Item: 
        Title: Supplementary data
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: The CAPE1 peptide confers resistance against bacterial wilt in tomato
    Author: Weiqi Zhang,Marc Planas-Marquès,Moyan Liang,Qingshan Zhang,Annemarie Vermeulen,Farnusch Kaschani,Markus Kaiser,Frank L. W. Takken,Nuria S. Coll,Marc Valls
    Subject: DOI: 10.1093/jxb/eraf145
Journal of Experimental Botany, Volume. XX, Issue. XX, 3 April 2025
Abstract 
Bacterial wilt caused by Ralstonia solanacearum is one of the most destructive bacterial diseases for which no effective treatment exists. There is an urgent need to understand the basis of resistance against this pathogen in order to engineer efficient strategies in the field. We previously demonstrated that resistant tomato plants limit bacterial movement in the apoplast and the xylem. As a first step to dissect the underlying mechanisms, we analysed the apoplast proteome upon challenge with R. solanacearum in the susceptible tomato cultivar Marmande and the resistant cultivar Hawaii 7996. Here, we described the xylem proteome in these same cultivars and compared it with the apoplastic proteome, revealing variety-dependent and infection-dependent changes. This proteomic analysis led to the identification of pathogenesis-related 1 (PR1) proteins as highly induced upon infection. Since PR1b was the most abundant PR1 protein in both the apoplast and the xylem, we concentrated on this family member to study the role of PR1s in the interaction between tomato and R. solanacearum. Surprisingly, lack of PR1b resulted in enhanced resistance to R. solanacearum in tomato, which could be due to an up-regulation of homologous genes in a compensatory effect as has been reported before. PR1 processing by an unknown protease in tomato results in the generation of the CAPE peptide. Treatment of tomato plants with the CAPE1 peptide resulted in restriction of R. solanacearum growth, via defence gene reprogramming. Future work in the lab will help determine which tomato secreted proteases cleave PR1s to generate CAPEs.
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iTextSharp.LGPLv2.Core 3.7.4.0
    CreationDate: Sat May 10 11:56:47 CEST 2025
    ModDate: Wed Jul 15 17:46:17 CEST 2026
    Trapped: False
   ID: 0xf9e07ace21918a7fed18ccd74ebc41ba, 0xfea51ce1652644fa8219798ebf7fe84e
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2955
      ImageHeight: 3288
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 420
      ImageHeight: 41
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 420
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 36
      ImageHeight: 36
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 36
      ImageHeight: 36
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 38
      ImageHeight: 38
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 35
      ImageHeight: 35
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 44
      ImageHeight: 49
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 44
      ImageHeight: 38
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 420
      ImageHeight: 3
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 947
      ImageHeight: 124
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 420
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 420
      ImageHeight: 41
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 647
      ImageHeight: 135
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 219
      ImageHeight: 143
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 285
      ImageHeight: 94
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 266
      ImageHeight: 71
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2801
      ImageHeight: 3906
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3240
      ImageHeight: 2536
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: WUMKWG+Arimo-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: HLHWMP+HelveticaNeueLTStd-Lt
      FontSubset: true
      FirstChar: 31
      LastChar: 233
      FontDescriptor: 
       FontName: HLHWMP+HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NHWDKX+HelveticaNeueLTStd-LtIt
      FontSubset: true
      FirstChar: 31
      LastChar: 150
      FontDescriptor: 
       FontName: NHWDKX+HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -214, 1099, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HHINUK+HelveticaNeueLTStd-BdIt
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: HHINUK+HelveticaNeueLTStd-BdIt
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -218, 1129, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ZSNWMA+MyriadPro-Bold
      FontSubset: true
      FirstChar: 31
      LastChar: 43
      FontDescriptor: 
       FontName: ZSNWMA+MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YXQWYC+Arial-BoldMT5
      FontSubset: true
      FirstChar: 32
      LastChar: 67
      FontDescriptor: 
       FontName: YXQWYC+Arial-BoldMT5
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT6
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: Arial-BoldMT6
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: SBQMSO+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 42
      FontDescriptor: 
       FontName: SBQMSO+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT4
      FirstChar: 32
      LastChar: 98
      FontDescriptor: 
       FontName: ArialMT4
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: SBQMSO+Arial-BoldMT2
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: SBQMSO+Arial-BoldMT2
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: XTBQKE+Arial-ItalicMT2
      FontSubset: true
      FirstChar: 32
      LastChar: 114
      FontDescriptor: 
       FontName: XTBQKE+Arial-ItalicMT2
       Flags: Nonsymbolic
       FontBBox: -517, -325, 1359, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DTMPQS+MyriadPro-Light
      FontSubset: true
      FirstChar: 30
      LastChar: 43
      FontDescriptor: 
       FontName: DTMPQS+MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -154, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: XTBQKE+SymbolMT
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: XTBQKE+SymbolMT
       Flags: Symbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: XTBQKE+Arial-BoldMT7
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: XTBQKE+Arial-BoldMT7
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: XTBQKE+Aptos-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: XTBQKE+Aptos-Bold
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: SBQMSO+ArnoPro-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: SBQMSO+ArnoPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -147, -376, 1511, 871
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YXQWYC+Arial-BoldItalicMT
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: YXQWYC+Arial-BoldItalicMT
       Flags: Nonsymbolic
       FontBBox: -560, -376, 1390, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAPIAY+Arial-BoldMT3
      FontSubset: true
      FirstChar: 32
      LastChar: 66
      FontDescriptor: 
       FontName: AAPIAY+Arial-BoldMT3
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAPIAY+Arial-ItalicMT
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: AAPIAY+Arial-ItalicMT
       Flags: Nonsymbolic
       FontBBox: -517, -325, 1359, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AAPIAY+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 89
      FontDescriptor: 
       FontName: AAPIAY+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT2
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: ArialMT2
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldItalicMT2
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: Arial-BoldItalicMT2
       Flags: Nonsymbolic
       FontBBox: -560, -376, 1390, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT4
      FirstChar: 32
      LastChar: 89
      FontDescriptor: 
       FontName: Arial-BoldMT4
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: YXQWYC+ArialMT3
      FontSubset: true
      FirstChar: 32
      LastChar: 89
      FontDescriptor: 
       FontName: YXQWYC+ArialMT3
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HLHWMP+HelveticaNeueLTStd-Lt
      FontSubset: true
      FirstChar: 31
      LastChar: 233
      FontDescriptor: 
       FontName: HLHWMP+HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WGYAHF+Helvetica-LightOblique
      FontSubset: true
      FirstChar: 28
      LastChar: 255
      FontDescriptor: 
       FontName: WGYAHF+Helvetica-LightOblique
       Flags: Nonsymbolic, Italic
       FontBBox: -164, -250, 1000, 979
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: QTJGUG+HelveticaNeueLTStd-Bd
      FontSubset: true
      FirstChar: 1
      LastChar: 82
      FontDescriptor: 
       FontName: QTJGUG+HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NHWDKX+HelveticaNeueLTStd-LtIt
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: NHWDKX+HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -214, 1099, 951
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HLHWMP+HelveticaNeueLTStd-Lt
      FontSubset: true
      FirstChar: 30
      LastChar: 233
      FontDescriptor: 
       FontName: HLHWMP+HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MIJLMA+HelveticaNeueLTStd-Md
      FontSubset: true
      FirstChar: 32
      LastChar: 83
      FontDescriptor: 
       FontName: MIJLMA+HelveticaNeueLTStd-Md
       Flags: Nonsymbolic
       FontBBox: -165, -221, 1066, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HLHWMP+HelveticaNeueLTStd-Lt
      FontSubset: true
      FirstChar: 29
      LastChar: 246
      FontDescriptor: 
       FontName: HLHWMP+HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ALFMAY+HelveticaNeueLTStd-Bd
      FontSubset: true
      FirstChar: 29
      LastChar: 253
      FontDescriptor: 
       FontName: ALFMAY+HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BemboStd2
      FirstChar: 23
      LastChar: 237
      FontDescriptor: 
       FontName: BemboStd2
       Flags: Serif, Nonsymbolic
       FontBBox: -206, -233, 1026, 896
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PWIECU+BemboStd-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: PWIECU+BemboStd-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -188, -233, 1086, 900
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GBOXGM+GandhariUnicode-Roman
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: GBOXGM+GandhariUnicode-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -752, -250, 1779, 944
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: FIKMSO+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: FIKMSO+ArialMT
       Flags: Nonsymbolic
       FontBBox: -664, -324, 2000, 1039
       FontFile2: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: WUMKWG+Arimo-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WUMKWG+Arimo-Bold
       Flags: Symbolic
       FontBBox: -482, -376, 1304, 1033
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 9.1-c001 79.675d0f7, 2023/06/11-19:21:16        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#">
         <dc:format>application/pdf</dc:format>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The CAPE1 peptide confers resistance against bacterial wilt in tomato</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">DOI: 10.1093/jxb/eraf145
Journal of Experimental Botany, Volume. XX, Issue. XX, 3 April 2025
Abstract 
Bacterial wilt caused by Ralstonia solanacearum is one of the most destructive bacterial diseases for which no effective treatment exists. There is an urgent need to understand the basis of resistance against this pathogen in order to engineer efficient strategies in the field. We previously demonstrated that resistant tomato plants limit bacterial movement in the apoplast and the xylem. As a first step to dissect the underlying mechanisms, we analysed the apoplast proteome upon challenge with R. solanacearum in the susceptible tomato cultivar Marmande and the resistant cultivar Hawaii 7996. Here, we described the xylem proteome in these same cultivars and compared it with the apoplastic proteome, revealing variety-dependent and infection-dependent changes. This proteomic analysis led to the identification of pathogenesis-related 1 (PR1) proteins as highly induced upon infection. Since PR1b was the most abundant PR1 protein in both the apoplast and the xylem, we concentrated on this family member to study the role of PR1s in the interaction between tomato and R. solanacearum. Surprisingly, lack of PR1b resulted in enhanced resistance to R. solanacearum in tomato, which could be due to an up-regulation of homologous genes in a compensatory effect as has been reported before. PR1 processing by an unknown protease in tomato results in the generation of the CAPE peptide. Treatment of tomato plants with the CAPE1 peptide resulted in restriction of R. solanacearum growth, via defence gene reprogramming. Future work in the lab will help determine which tomato secreted proteases cleave PR1s to generate CAPEs.</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Experimental Biology.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Weiqi Zhang,Marc Planas-Marquès,Moyan Liang,Qingshan Zhang,Annemarie Vermeulen,Farnusch Kaschani,Markus Kaiser,Frank L. W. Takken,Nuria S. Coll,Marc Valls</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li> Bacterial wilt,</rdf:li>
               <rdf:li>PR1 proteins,</rdf:li>
               <rdf:li>Ralstonia solanacearum,</rdf:li>
               <rdf:li>Solanum lycopersicum,</rdf:li>
               <rdf:li>tomato disease resistance,</rdf:li>
               <rdf:li>xylem proteome</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <xmp:CreateDate>2025-05-10T14:56:47+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2026-07-15T15:46:17+00:00</xmp:ModifyDate>
         <xmp:MetadataDate>2026-07-15T15:46:17+00:00</xmp:MetadataDate>
         <xmpMM:InstanceID>uuid:8a67f32e-3888-44da-abf7-8839b9eb4003</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:840A93442E2068118083C1556DCA13C0</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:18e45c2f-bd2d-ff4b-8a80-e20bb4b01d73</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:083f03c7-ca15-1c41-b885-af5bef3feaca</stRef:instanceID>
            <stRef:documentID>xmp.did:0b6d3d89-3aae-be43-86eb-8b1478d77bde</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 15.1 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2025-05-10T14:56:47+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:f7b01c6e-2f07-4162-9e11-00c2b68c9f72</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-3a</stEvt:parameters>
                  <stEvt:softwareAgent>Preflight</stEvt:softwareAgent>
                  <stEvt:when>2025-05-10T14:58:24+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iTextSharp.LGPLv2.Core 3.7.4.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 378, 54, 526, 45
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 101, 588, 104, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 215, 588, 218, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 220, 588, 224, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 290, 588, 294, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 296, 588, 299, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 383, 588, 387, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 497, 588, 501, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 133, 575, 137, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 211, 575, 215, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 215, 577, 229, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 575, 326, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 325, 577, 339, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 575, 406, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 407, 575, 411, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 413, 575, 416, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 416, 577, 430, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 503, 575, 506, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 508, 575, 512, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 514, 575, 517, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 1508
      Annotation: 
       Subtype: Link
       Rect: 516, 577, 530, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 468, 256, 457
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 269, 468, 339, 457
       Flags: Print
       AppearanceDictionary: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 659, 301, 647
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 647, 92, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 47, 599, 94, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 157, 575, 249, 563
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 209, 539, 299, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 527, 112, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 116, 527, 187, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 93, 491, 173, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 86, 455, 196, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 240, 431, 301, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 419, 64, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 261, 359, 301, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 347, 89, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 47, 323, 111, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 114, 323, 200, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 204, 323, 299, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 311, 130, 299
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 135, 311, 224, 299
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 124, 275, 207, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 211, 275, 296, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 70, 179, 142, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 147, 179, 213, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 71, 143, 143, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 149, 143, 234, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 158, 119, 299, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 107, 148, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 249, 83, 301, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 695, 362, 683
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 527, 683, 570, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 313, 671, 357, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 401, 647, 480, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 485, 647, 551, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 554, 647, 570, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 313, 635, 377, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 380, 635, 461, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 466, 623, 568, 611
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 611, 377, 599
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 381, 611, 461, 599
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 408, 575, 480, 563
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 497, 491, 567, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 400, 467, 470, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 470, 431, 565, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 438, 383, 508, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 340, 323, 398, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 428, 287, 493, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 356, 263, 495, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 501, 263, 570, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 251, 333, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 543, 239, 570, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 227, 360, 215
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 316, 143, 395, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 399, 143, 453, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 458, 143, 523, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 527, 143, 570, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 131, 333, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 549, 107, 570, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 313, 95, 359, 83
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 715, 189, 703
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 95, 691, 164, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 169, 691, 223, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 142, 607, 216, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 78, 571, 155, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 285, 547, 299, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 42, 535, 87, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 269, 475, 299, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 42, 463, 126, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 233, 427, 299, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 42, 415, 87, 403
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 528, 714, 568, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 311, 704, 328, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 350, 664, 448, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 397, 474, 494, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 242, 691, 301, 681
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 681, 61, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 47, 574, 123, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 116, 364, 181, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 203, 168, 263, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 104, 158, 185, 148
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 81, 148, 140, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 541, 594, 570, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 313, 584, 351, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 316, 440, 393, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 487, 440, 570, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 430, 344, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 430, 496, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 467, 390, 553, 380
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 516, 370, 570, 360
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 360, 343, 350
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 316, 330, 472, 320
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 495, 320, 566, 310
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 258, 554, 247
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 396, 188, 441, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 378, 168, 423, 157
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 316, 98, 432, 87
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 82, 592, 162, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 257, 441, 299, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 42, 431, 64, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 132, 359, 201, 349
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 152, 189, 217, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 124, 78, 193, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 347, 694, 421, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 424, 694, 510, 684
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 514, 694, 568, 684
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 311, 684, 341, 674
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 664, 377, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 335, 644, 424, 634
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 574, 483, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 392, 524, 463, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 369, 474, 454, 464
       Flags: Print
       AppearanceDictionary: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 135, 618, 205, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 248, 434, 301, 424
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 44, 424, 68, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 175, 404, 260, 394
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 139, 222, 257, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 136, 162, 227, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 232, 162, 301, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 150, 64, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 70, 150, 153, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 158, 150, 179, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 184, 150, 299, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 138, 122, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 212, 126, 301, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 114, 64, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 523, 607, 553, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 558, 607, 565, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 363, 559, 475, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 488, 535, 570, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 523, 323, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 335, 499, 434, 487
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 475, 570, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 463, 348, 451
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 352, 439, 460, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 316, 331, 346, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 555, 223, 570, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 313, 211, 326, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 358, 187, 389, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 511, 151, 535, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 540, 151, 570, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 313, 139, 398, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 316, 103, 347, 91
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 498, 91, 528, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
    Page: 
     Sequence: 7
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 98, 715, 124, 703
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 47, 691, 142, 679
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 283, 608, 301, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 715, 360, 703
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 365, 715, 450, 703
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 456, 715, 551, 703
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 464, 607, 557, 595
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 330, 97, 427, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 273, 691, 297, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 42, 679, 144, 667
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 109, 631, 140, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 145, 631, 247, 619
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 224, 583, 254, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 236, 499, 299, 487
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 42, 487, 70, 475
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 153, 475, 248, 461
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 145, 367, 216, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 221, 367, 278, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 217, 319, 299, 307
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 42, 307, 59, 295
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 236, 247, 299, 235
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 42, 235, 77, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 82, 235, 90, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 236, 199, 299, 187
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 42, 187, 72, 175
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 142, 103, 172, 91
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 532, 655, 563, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 418, 619, 449, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 417, 559, 514, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 314, 535, 408, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 391, 384, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 451, 307, 482, 295
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 442, 271, 474, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 440, 235, 471, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 553, 211, 568, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 311, 199, 323, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 466, 139, 497, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 134, 175, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
    Page: 
     Sequence: 11
    Page: 
     Sequence: 12
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 193, 631, 268, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 45, 595, 125, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 493, 643, 518, 631
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 498, 301, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 44, 486, 88, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 142, 474, 221, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 177, 414, 266, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 47, 366, 150, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 47, 342, 124, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 153, 234, 178, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 269, 222, 301, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 210, 91, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 271, 210, 301, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 198, 91, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 100, 150, 208, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 214, 150, 296, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 78, 114, 169, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 173, 114, 251, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 316, 703, 390, 691
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 385, 583, 408, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 507, 571, 570, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 559, 342, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 537, 547, 570, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 535, 357, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 516, 523, 570, 511
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 511, 333, 499
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 330, 499, 400, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 461, 415, 492, 403
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 481, 379, 570, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 367, 333, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 339, 367, 418, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 388, 343, 463, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 522, 331, 570, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 313, 319, 333, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 343, 271, 374, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 414, 247, 448, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 454, 247, 462, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 481, 211, 513, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 517, 211, 524, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 316, 175, 413, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 472, 163, 504, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 509, 163, 516, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 545, 127, 570, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 313, 115, 397, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 402, 115, 480, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 400, 79, 496, 65
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 229, 703, 299, 689
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 42, 691, 62, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 67, 691, 88, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 45, 667, 142, 655
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 198, 619, 272, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 277, 619, 299, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 42, 607, 89, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 95, 607, 189, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 186, 559, 259, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 71, 511, 145, 499
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 230, 451, 299, 439
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 42, 439, 108, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 114, 439, 208, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 214, 439, 294, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 45, 391, 139, 379
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 95, 355, 191, 343
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 172, 307, 232, 295
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 126, 259, 155, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 182, 223, 213, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 264, 211, 294, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 45, 127, 127, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 358, 655, 429, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 433, 655, 502, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 507, 655, 563, 643
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 376, 619, 407, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 520, 595, 563, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 437, 571, 467, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 413, 547, 436, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 359, 475, 381, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 382, 427, 407, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 397, 379, 420, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 348, 355, 422, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 398, 295, 466, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 381, 271, 510, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 514, 271, 568, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 311, 259, 331, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 509, 247, 568, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 311, 235, 331, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 520, 139, 568, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 311, 127, 331, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 199, 691, 275, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 256, 559, 301, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 44, 547, 65, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 113, 499, 185, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 195
      Annotation: 
       Subtype: Link
       Rect: 252, 369, 297, 357
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 316, 220, 387, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 462, 220, 570, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 209, 342, 198
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 158, 570, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 149, 510, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 110, 570, 101
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 313, 101, 501, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 714, 193, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 684, 299, 675
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 675, 229, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 636, 204, 627
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 42, 606, 299, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 597, 81, 588
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 567, 299, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 42, 558, 57, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 42, 537, 140, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 507, 299, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 477, 274, 468
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 42, 438, 100, 429
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 42, 408, 299, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 42, 378, 276, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 42, 339, 222, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 42, 309, 299, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 270, 300, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 261, 60, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 42, 231, 215, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 42, 192, 156, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 162, 120, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 42, 141, 139, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 42, 111, 222, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 311, 714, 471, 705
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 684, 461, 675
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 654, 569, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 645, 354, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 615, 568, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 606, 388, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 576, 569, 567
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 567, 408, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 537, 459, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 498, 352, 489
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 311, 468, 468, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 447, 418, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 417, 495, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 311, 378, 464, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 311, 348, 452, 339
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 311, 318, 569, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 309, 359, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 311, 288, 493, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 258, 511, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 311, 219, 544, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 180, 568, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 311, 171, 372, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 311, 141, 404, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 111, 403, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 90, 423, 81
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 693, 301, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 44, 684, 120, 675
       Flags: Print
       AppearanceDictionary: true
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 44, 654, 231, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 44, 624, 301, 615
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 44, 585, 150, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 44, 555, 189, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 44, 525, 251, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 44, 495, 179, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 44, 465, 187, 456
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 44, 426, 211, 417
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 44, 396, 121, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 44, 366, 174, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 44, 336, 233, 327
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 44, 297, 168, 288
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 44, 276, 301, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 44, 267, 201, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 44, 238, 301, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 44, 228, 164, 219
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 44, 199, 182, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 44, 168, 302, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 44, 159, 198, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 44, 129, 301, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 44, 120, 109, 111
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 44, 90, 236, 81
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 693, 443, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 313, 663, 571, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 313, 654, 530, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 313, 624, 571, 615
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 313, 615, 492, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 313, 585, 478, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 313, 555, 570, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 516, 571, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 507, 326, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 477, 570, 468
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 313, 468, 429, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 366, 450, 435, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 313, 438, 570, 429
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 313, 429, 449, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 313, 399, 465, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 313, 378, 428, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 313, 348, 571, 339
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 313, 339, 350, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 313, 318, 570, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 309, 423, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 270, 457, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 240, 431, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 210, 344, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 180, 470, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 313, 159, 461, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 313, 138, 434, 129
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 313, 99, 379, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 693, 147, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 42, 672, 299, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 663, 300, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 42, 654, 50, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 189
      Annotation: 
       Subtype: Link
       Rect: 311, 714, 485, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 684, 447, 674
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 311, 654, 441, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
  Checksum: 966a89f5
   Type: CRC32
  Checksum: c21f80dc4d19f4fc4f4949ac9c86e485
   Type: MD5
  Checksum: 203d524a445d303aa7f6a86126b80d5271da642e
   Type: SHA-1
  Checksum: 2ea3aa06d0885dd0809eb7c8a28813e60ab399d07ef00d07700dcf2dd1b0fd3b
   Type: SHA-256