ac0e331b3141a523c5986e58fdfcb503 IntJouMolSci_a2025_m7_v26_n15.pdf fc6b6e008117194707565981fdfe6e3fec9fb938 IntJouMolSci_a2025_m7_v26_n15.pdf 29ac92344cbcd807212249141a73b3f5b26577346d30f18e7e766eb5dae4e00d IntJouMolSci_a2025_m7_v26_n15.pdf Title: Brassinosteroids in Cucurbits: Modulators of Plant Growth Architecture and Stress Response Subject: Brassinosteroids (BRs) are steroid hormones that are essential for plant growth, development, and environmental adaptation. They control the division, elongation, and differentiation of various cell types throughout the entire plant life cycle, affecting growth and the stress response. Therefore, fine-tuning of BR biosynthesis and modulation of signaling pathways offer possibilities for developing cultivars characterized by adjusted plant architecture or improved stress tolerance to benefit crop production. Additionally, precise BR treatments can be employed to increase the productivity of crop plants. This review aims to provide a comprehensive summary of the genetic basis of traits related to BR metabolism and signaling in cucurbits, the second largest vegetable family, which contributes significantly to global vegetable production and nutritional security. We summarize the current knowledge concerning BR biosynthesis mutants, the role of BRs in stress mitigation, and the potential of the exogenous application of BRs to alleviate stress during cucurbit production. We also discuss how genes related to BR metabolism can be used to develop gene editing strategies to advance precision breeding in cucurbits. Keywords: crop improvement; crop productivity; dwarfism; plant development; plant hormones; precision breeding Author: Renata Słomnicka, Magdalena Cieplak, Ana Montserrat Martín-Hernández and Grzegorz Bartoszewski Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Sat Jul 26 10:00:43 2025 CEST ModDate: Sat Jul 26 10:03:14 2025 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 30 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1695060 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ILXGXV+VnURWPalladioL Type 1 Custom yes yes yes 115 0 YEAWQB+URWPalladioL-Bold Type 1 Custom yes yes yes 116 0 YAOIWP+URWPalladioL-Roma Type 1 Custom yes yes yes 117 0 YHRSDW+URWPalladioL-Ital Type 1 Custom yes yes yes 118 0 MDJLZU+EURM10 Type 1 Builtin yes yes yes 185 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 173 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 174 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 175 0 CHGLKM+TimesNewRomanPSMT TrueType WinAnsi yes yes no 176 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 223 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 224 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 225 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 290 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 291 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 292 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 337 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 338 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 339 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 439 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 440 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 441 0 DCWRCI+PazoMath Type 1 Builtin yes yes yes 589 0 IAFQNP+CMSY10 Type 1 Builtin yes yes yes 643 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 846 0 CHGKHL+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 847 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 848 0 CHGKIN+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 839 0 CHGKIM+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 840 0 CHGLKM+TimesNewRomanPSMT TrueType WinAnsi yes yes no 841 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-07-21 04:16:29 CEST RepresentationInformation: IntJouMolSci_a2025_m7_v26_n15.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-07-20 15:30:33 CEST Size: 1695060 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1114 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Chemical Structure and Occurrence of BRs Item: Title: BR Biosynthesis and Signaling Item: Title: Functions of BRs in Plants Item: Title: Crosstalk Between BRs and Other Phytohormones Children: Item: Title: Interaction Between BRs and Ethylene Item: Title: Interaction Between BRs and Gibberellins Item: Title: Interaction Between BRs and Auxins Item: Title: Mutants in Cucurbits with Affected BR Biosynthesis Item: Title: Role of BRs in the Development and Growth of Cucurbits Item: Title: BRs in the Stress Response of Cucurbits Children: Item: Title: Abiotic Stress Item: Title: Biotic Stress Item: Title: Application of BRs to Alleviate Stress During Cucurbit Production Item: Title: Perspectives and Concluding Remarks Item: Title: References Info: Title: Brassinosteroids in Cucurbits: Modulators of Plant Growth Architecture and Stress Response Author: Renata Słomnicka, Magdalena Cieplak, Ana Montserrat Martín-Hernández and Grzegorz Bartoszewski Subject: Brassinosteroids (BRs) are steroid hormones that are essential for plant growth, development, and environmental adaptation. They control the division, elongation, and differentiation of various cell types throughout the entire plant life cycle, affecting growth and the stress response. Therefore, fine-tuning of BR biosynthesis and modulation of signaling pathways offer possibilities for developing cultivars characterized by adjusted plant architecture or improved stress tolerance to benefit crop production. Additionally, precise BR treatments can be employed to increase the productivity of crop plants. This review aims to provide a comprehensive summary of the genetic basis of traits related to BR metabolism and signaling in cucurbits, the second largest vegetable family, which contributes significantly to global vegetable production and nutritional security. We summarize the current knowledge concerning BR biosynthesis mutants, the role of BRs in stress mitigation, and the potential of the exogenous application of BRs to alleviate stress during cucurbit production. We also discuss how genes related to BR metabolism can be used to develop gene editing strategies to advance precision breeding in cucurbits. Keywords: crop improvement; crop productivity; dwarfism; plant development; plant hormones; precision breeding Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Sat Jul 26 10:00:43 CEST 2025 ModDate: Sat Jul 26 10:03:14 CEST 2025 ID: 0x1217ff8b236c594067ebde1098cf295e, 0x2780e801525d0d4cc2f96f9457c02a11 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ILXGXV+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 177 FontDescriptor: FontName: ILXGXV+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFQNP+CMSY10 FontSubset: true FirstChar: 0 LastChar: 48 FontDescriptor: FontName: IAFQNP+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true ToUnicode: true Font: BaseFont: YEAWQB+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 237 FontDescriptor: FontName: YEAWQB+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: YAOIWP+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: YAOIWP+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: YHRSDW+URWPalladioL-Ital FontSubset: true FirstChar: 44 LastChar: 150 FontDescriptor: FontName: YHRSDW+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MDJLZU+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: MDJLZU+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true ToUnicode: true Font: BaseFont: DCWRCI+PazoMath FontSubset: true FirstChar: 70 LastChar: 70 FontDescriptor: FontName: DCWRCI+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true ToUnicode: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 54, 177, 152, 186 Annotation: Subtype: Link Rect: 34, 165, 77, 174 Annotation: Subtype: Link Rect: 36, 75, 152, 84 Annotation: Subtype: Link Rect: 34, 63, 89, 72 Annotation: Subtype: Link Rect: 34, 773, 180, 809 Annotation: Subtype: Link Rect: 515, 773, 560, 809 Annotation: Subtype: Link Rect: 123, 663, 134, 677 Annotation: Subtype: Link Rect: 546, 663, 557, 677 Annotation: Subtype: Link Rect: 412, 207, 419, 216 ActionDest: 81 Annotation: Subtype: Link Rect: 203, 95, 210, 104 ActionDest: 81 Annotation: Subtype: Link Rect: 461, 81, 468, 90 ActionDest: 81 Annotation: Subtype: Link Rect: 421, 27, 560, 37 Annotation: Subtype: Link Rect: 34, 344, 87, 363 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 319, 717, 326, 726 ActionDest: 81 Annotation: Subtype: Link Rect: 398, 703, 405, 712 ActionDest: 81 Annotation: Subtype: Link Rect: 438, 661, 445, 670 ActionDest: 81 Annotation: Subtype: Link Rect: 408, 619, 415, 628 ActionDest: 81 Annotation: Subtype: Link Rect: 416, 619, 423, 628 ActionDest: 81 Annotation: Subtype: Link Rect: 501, 549, 508, 559 ActionDest: 81 Annotation: Subtype: Link Rect: 511, 549, 522, 559 ActionDest: 81 Annotation: Subtype: Link Rect: 420, 522, 432, 531 ActionDest: 81 Annotation: Subtype: Link Rect: 211, 452, 223, 461 ActionDest: 81 Annotation: Subtype: Link Rect: 195, 270, 206, 279 ActionDest: 81 Annotation: Subtype: Link Rect: 207, 270, 219, 279 ActionDest: 81 Annotation: Subtype: Link Rect: 402, 242, 414, 251 ActionDest: 81 Annotation: Subtype: Link Rect: 479, 228, 491, 237 ActionDest: 81 Annotation: Subtype: Link Rect: 531, 214, 543, 223 ActionDest: 81 Annotation: Subtype: Link Rect: 544, 214, 556, 223 ActionDest: 81 Annotation: Subtype: Link Rect: 470, 172, 482, 181 ActionDest: 81 Annotation: Subtype: Link Rect: 468, 142, 475, 154 ActionDest: 19 Annotation: Subtype: Link Rect: 188, 89, 200, 98 ActionDest: 81 Annotation: Subtype: Link Rect: 446, 75, 458, 84 ActionDest: 81 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 281, 717, 293, 726 ActionDest: 81 Annotation: Subtype: Link Rect: 293, 717, 305, 726 ActionDest: 81 Annotation: Subtype: Link Rect: 525, 703, 537, 712 ActionDest: 81 Annotation: Subtype: Link Rect: 201, 658, 208, 670 ActionDest: 19 Annotation: Subtype: Link Rect: 217, 661, 229, 670 ActionDest: 81 Annotation: Subtype: Link Rect: 232, 661, 244, 670 ActionDest: 81 Annotation: Subtype: Link Rect: 253, 647, 265, 656 ActionDest: 81 Annotation: Subtype: Link Rect: 445, 633, 457, 642 ActionDest: 81 Annotation: Subtype: Link Rect: 457, 633, 469, 642 ActionDest: 81 Annotation: Subtype: Link Rect: 190, 361, 202, 370 ActionDest: 270 Annotation: Subtype: Link Rect: 544, 305, 556, 314 ActionDest: 270 Annotation: Subtype: Link Rect: 386, 249, 398, 258 ActionDest: 81 Annotation: Subtype: Link Rect: 242, 208, 254, 217 ActionDest: 81 Annotation: Subtype: Link Rect: 255, 207, 267, 217 ActionDest: 270 Annotation: Subtype: Link Rect: 347, 194, 359, 203 ActionDest: 270 Annotation: Subtype: Link Rect: 362, 194, 374, 203 ActionDest: 270 Annotation: Subtype: Link Rect: 351, 93, 358, 105 ActionDest: 135 Annotation: Subtype: Link Rect: 365, 96, 377, 105 ActionDest: 81 Annotation: Subtype: Link Rect: 378, 96, 390, 105 ActionDest: 270 Annotation: Subtype: Link Rect: 390, 96, 402, 105 ActionDest: 270 Annotation: Subtype: Link Rect: 405, 96, 417, 105 ActionDest: 270 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 193, 758, 205, 767 ActionDest: 270 Annotation: Subtype: Link Rect: 226, 689, 238, 698 ActionDest: 270 Annotation: Subtype: Link Rect: 238, 689, 250, 698 ActionDest: 270 Annotation: Subtype: Link Rect: 189, 383, 200, 391 ActionDest: 81 Annotation: Subtype: Link Rect: 200, 383, 211, 391 ActionDest: 270 Annotation: Subtype: Link Rect: 211, 383, 222, 391 ActionDest: 270 Annotation: Subtype: Link Rect: 347, 278, 354, 290 ActionDest: 24 Annotation: Subtype: Link Rect: 269, 197, 281, 206 ActionDest: 270 Annotation: Subtype: Link Rect: 282, 169, 294, 178 ActionDest: 270 Annotation: Subtype: Link Rect: 295, 169, 307, 178 ActionDest: 270 Annotation: Subtype: Link Rect: 400, 141, 412, 151 ActionDest: 270 Annotation: Subtype: Link Rect: 211, 86, 223, 95 ActionDest: 270 Annotation: Subtype: Link Rect: 226, 86, 238, 95 ActionDest: 270 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 402, 717, 414, 726 ActionDest: 270 Annotation: Subtype: Link Rect: 347, 675, 359, 684 ActionDest: 270 Annotation: Subtype: Link Rect: 357, 619, 369, 628 ActionDest: 270 Annotation: Subtype: Link Rect: 461, 275, 472, 283 ActionDest: 270 Annotation: Subtype: Link Rect: 472, 275, 483, 283 ActionDest: 270 Annotation: Subtype: Link Rect: 483, 275, 494, 283 ActionDest: 270 Annotation: Subtype: Link Rect: 492, 180, 499, 192 ActionDest: 136 Annotation: Subtype: Link Rect: 505, 183, 517, 192 ActionDest: 270 Annotation: Subtype: Link Rect: 518, 183, 530, 192 ActionDest: 270 Annotation: Subtype: Link Rect: 314, 141, 326, 150 ActionDest: 270 Annotation: Subtype: Link Rect: 329, 141, 341, 150 ActionDest: 270 Annotation: Subtype: Link Rect: 544, 113, 556, 122 ActionDest: 270 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 345, 758, 357, 767 ActionDest: 270 Annotation: Subtype: Link Rect: 248, 730, 260, 740 ActionDest: 270 Annotation: Subtype: Link Rect: 305, 703, 317, 712 ActionDest: 270 Annotation: Subtype: Link Rect: 510, 689, 522, 698 ActionDest: 270 Annotation: Subtype: Link Rect: 276, 322, 288, 331 ActionDest: 407 Annotation: Subtype: Link Rect: 463, 294, 475, 303 ActionDest: 407 Annotation: Subtype: Link Rect: 492, 280, 504, 289 ActionDest: 407 Annotation: Subtype: Link Rect: 520, 266, 532, 275 ActionDest: 407 Annotation: Subtype: Link Rect: 532, 266, 544, 275 ActionDest: 407 Annotation: Subtype: Link Rect: 310, 238, 322, 247 ActionDest: 270 Annotation: Subtype: Link Rect: 234, 224, 246, 233 ActionDest: 407 Annotation: Subtype: Link Rect: 247, 224, 259, 233 ActionDest: 407 Annotation: Subtype: Link Rect: 458, 196, 470, 205 ActionDest: 407 Annotation: Subtype: Link Rect: 406, 168, 418, 178 ActionDest: 407 Annotation: Subtype: Link Rect: 247, 127, 258, 136 ActionDest: 407 Annotation: Subtype: Link Rect: 531, 113, 543, 122 ActionDest: 407 Annotation: Subtype: Link Rect: 224, 85, 236, 94 ActionDest: 270 Annotation: Subtype: Link Rect: 361, 71, 373, 80 ActionDest: 407 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 282, 758, 294, 767 ActionDest: 407 Annotation: Subtype: Link Rect: 349, 744, 361, 754 ActionDest: 407 Annotation: Subtype: Link Rect: 269, 717, 281, 726 ActionDest: 407 Annotation: Subtype: Link Rect: 417, 689, 429, 698 ActionDest: 407 Annotation: Subtype: Link Rect: 346, 633, 358, 642 ActionDest: 81 Annotation: Subtype: Link Rect: 359, 633, 371, 642 ActionDest: 270 Annotation: Subtype: Link Rect: 371, 633, 383, 642 ActionDest: 270 Annotation: Subtype: Link Rect: 384, 633, 396, 642 ActionDest: 407 Annotation: Subtype: Link Rect: 254, 605, 266, 614 ActionDest: 407 Annotation: Subtype: Link Rect: 528, 577, 540, 586 ActionDest: 407 Annotation: Subtype: Link Rect: 291, 550, 302, 559 ActionDest: 407 Annotation: Subtype: Link Rect: 531, 536, 543, 545 ActionDest: 407 Annotation: Subtype: Link Rect: 544, 536, 556, 545 ActionDest: 407 Annotation: Subtype: Link Rect: 211, 508, 223, 517 ActionDest: 407 Annotation: Subtype: Link Rect: 224, 508, 236, 517 ActionDest: 407 Annotation: Subtype: Link Rect: 401, 466, 413, 475 ActionDest: 270 Annotation: Subtype: Link Rect: 211, 257, 223, 266 ActionDest: 407 Annotation: Subtype: Link Rect: 502, 241, 509, 253 ActionDest: 40 Annotation: Subtype: Link Rect: 527, 215, 539, 225 ActionDest: 407 Annotation: Subtype: Link Rect: 357, 188, 369, 197 ActionDest: 467 Annotation: Subtype: Link Rect: 372, 188, 384, 197 ActionDest: 467 Annotation: Subtype: Link Rect: 372, 132, 384, 141 ActionDest: 467 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 273, 730, 285, 740 ActionDest: 467 Annotation: Subtype: Link Rect: 385, 382, 397, 392 ActionDest: 467 Annotation: Subtype: Link Rect: 199, 312, 206, 324 ActionDest: 40 Annotation: Subtype: Link Rect: 529, 300, 541, 309 ActionDest: 467 Annotation: Subtype: Link Rect: 544, 300, 556, 309 ActionDest: 467 Annotation: Subtype: Link Rect: 384, 286, 396, 295 ActionDest: 467 Annotation: Subtype: Link Rect: 396, 286, 408, 295 ActionDest: 467 Annotation: Subtype: Link Rect: 468, 286, 480, 295 ActionDest: 467 Annotation: Subtype: Link Rect: 211, 147, 223, 156 ActionDest: 467 Annotation: Subtype: Link Rect: 361, 79, 373, 88 ActionDest: 270 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 413, 744, 425, 754 ActionDest: 467 Annotation: Subtype: Link Rect: 416, 717, 428, 726 ActionDest: 467 Annotation: Subtype: Link Rect: 283, 576, 295, 585 ActionDest: 81 Annotation: Subtype: Link Rect: 353, 518, 360, 530 ActionDest: 449 Annotation: Subtype: Link Rect: 470, 493, 482, 502 ActionDest: 467 Annotation: Subtype: Link Rect: 485, 493, 497, 502 ActionDest: 467 Annotation: Subtype: Link Rect: 498, 409, 510, 418 ActionDest: 467 Annotation: Subtype: Link Rect: 282, 367, 293, 376 ActionDest: 270 Annotation: Subtype: Link Rect: 293, 340, 305, 349 ActionDest: 270 Annotation: Subtype: Link Rect: 306, 340, 318, 349 ActionDest: 270 Annotation: Subtype: Link Rect: 220, 298, 232, 307 ActionDest: 270 Annotation: Subtype: Link Rect: 517, 270, 529, 279 ActionDest: 270 Annotation: Subtype: Link Rect: 539, 256, 551, 265 ActionDest: 270 Annotation: Subtype: Link Rect: 459, 186, 471, 195 ActionDest: 467 Annotation: Subtype: Link Rect: 248, 158, 260, 168 ActionDest: 270 Annotation: Subtype: Link Rect: 260, 158, 272, 168 ActionDest: 270 Annotation: Subtype: Link Rect: 421, 131, 433, 140 ActionDest: 270 Annotation: Subtype: Link Rect: 433, 131, 445, 140 ActionDest: 467 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 418, 758, 430, 767 ActionDest: 467 Annotation: Subtype: Link Rect: 326, 730, 338, 740 ActionDest: 270 Annotation: Subtype: Link Rect: 271, 675, 283, 684 ActionDest: 467 Annotation: Subtype: Link Rect: 350, 619, 362, 628 ActionDest: 467 Annotation: Subtype: Link Rect: 362, 619, 374, 628 ActionDest: 467 Annotation: Subtype: Link Rect: 374, 619, 386, 628 ActionDest: 467 Annotation: Subtype: Link Rect: 449, 563, 461, 572 ActionDest: 467 Annotation: Subtype: Link Rect: 462, 563, 474, 572 ActionDest: 467 Annotation: Subtype: Link Rect: 390, 508, 402, 517 ActionDest: 467 Annotation: Subtype: Link Rect: 460, 466, 472, 475 ActionDest: 467 Annotation: Subtype: Link Rect: 236, 438, 248, 447 ActionDest: 467 Annotation: Subtype: Link Rect: 248, 438, 260, 447 ActionDest: 467 Annotation: Subtype: Link Rect: 375, 424, 387, 433 ActionDest: 270 Annotation: Subtype: Link Rect: 388, 424, 400, 433 ActionDest: 467 Annotation: Subtype: Link Rect: 492, 410, 504, 419 ActionDest: 467 Annotation: Subtype: Link Rect: 252, 382, 264, 391 ActionDest: 270 Annotation: Subtype: Link Rect: 529, 368, 541, 377 ActionDest: 270 Annotation: Subtype: Link Rect: 312, 327, 324, 336 ActionDest: 467 Annotation: Subtype: Link Rect: 194, 299, 206, 308 ActionDest: 467 Annotation: Subtype: Link Rect: 410, 187, 422, 196 ActionDest: 467 Annotation: Subtype: Link Rect: 462, 173, 474, 182 ActionDest: 467 Annotation: Subtype: Link Rect: 288, 76, 300, 85 ActionDest: 467 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 367, 730, 379, 740 ActionDest: 467 Annotation: Subtype: Link Rect: 482, 591, 494, 600 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 496, 538, 505 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 426, 538, 435 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 331, 538, 340 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 225, 538, 234 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 148, 538, 157 ActionDest: 467 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 526, 683, 538, 692 ActionDest: 467 Annotation: Subtype: Link Rect: 526, 624, 538, 633 ActionDest: 467 Annotation: Subtype: Link Rect: 442, 484, 449, 496 ActionDest: 57 Annotation: Subtype: Link Rect: 235, 403, 247, 412 ActionDest: 467 Annotation: Subtype: Link Rect: 325, 403, 342, 412 ActionDest: 467 Annotation: Subtype: Link Rect: 525, 375, 542, 384 ActionDest: 467 Annotation: Subtype: Link Rect: 225, 347, 242, 356 ActionDest: 467 Annotation: Subtype: Link Rect: 521, 333, 538, 342 ActionDest: 600 Annotation: Subtype: Link Rect: 539, 333, 556, 342 ActionDest: 600 Annotation: Subtype: Link Rect: 271, 319, 288, 328 ActionDest: 600 Annotation: Subtype: Link Rect: 198, 222, 214, 231 ActionDest: 600 Annotation: Subtype: Link Rect: 452, 194, 469, 203 ActionDest: 600 Annotation: Subtype: Link Rect: 470, 194, 487, 203 ActionDest: 600 Annotation: Subtype: Link Rect: 465, 69, 482, 78 ActionDest: 600 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 281, 744, 298, 754 ActionDest: 600 Annotation: Subtype: Link Rect: 308, 619, 325, 628 ActionDest: 600 Annotation: Subtype: Link Rect: 523, 554, 535, 563 ActionDest: 467 Annotation: Subtype: Link Rect: 520, 537, 537, 546 ActionDest: 600 Annotation: Subtype: Link Rect: 520, 514, 537, 523 ActionDest: 600 Annotation: Subtype: Link Rect: 520, 492, 537, 501 ActionDest: 600 Annotation: Subtype: Link Rect: 520, 469, 537, 478 ActionDest: 600 Annotation: Subtype: Link Rect: 520, 446, 537, 455 ActionDest: 600 Annotation: Subtype: Link Rect: 520, 429, 537, 438 ActionDest: 467 Annotation: Subtype: Link Rect: 520, 413, 537, 422 ActionDest: 467 Annotation: Subtype: Link Rect: 408, 306, 415, 318 ActionDest: 67 Annotation: Subtype: Link Rect: 396, 241, 413, 250 ActionDest: 600 Annotation: Subtype: Link Rect: 413, 241, 430, 250 ActionDest: 600 Annotation: Subtype: Link Rect: 381, 157, 398, 166 ActionDest: 600 Annotation: Subtype: Link Rect: 328, 101, 345, 110 ActionDest: 600 Annotation: Subtype: Link Rect: 539, 87, 556, 97 ActionDest: 600 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 542, 730, 554, 740 ActionDest: 467 Annotation: Subtype: Link Rect: 193, 633, 210, 642 ActionDest: 600 Annotation: Subtype: Link Rect: 478, 591, 495, 600 ActionDest: 600 Annotation: Subtype: Link Rect: 276, 549, 293, 559 ActionDest: 600 Annotation: Subtype: Link Rect: 217, 384, 234, 393 ActionDest: 600 Annotation: Subtype: Link Rect: 317, 356, 334, 365 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 235, 538, 244 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 173, 538, 182 ActionDest: 600 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 521, 682, 538, 691 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 634, 538, 643 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 562, 538, 571 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 478, 538, 487 ActionDest: 600 Annotation: Subtype: Link Rect: 523, 421, 535, 430 ActionDest: 467 Annotation: Subtype: Link Rect: 363, 318, 375, 327 ActionDest: 270 Annotation: Subtype: Link Rect: 375, 318, 392, 327 ActionDest: 600 Annotation: Subtype: Link Rect: 395, 318, 412, 327 ActionDest: 600 Annotation: Subtype: Link Rect: 393, 273, 400, 285 ActionDest: 626 Annotation: Subtype: Link Rect: 285, 234, 297, 243 ActionDest: 467 Annotation: Subtype: Link Rect: 297, 234, 314, 243 ActionDest: 600 Annotation: Subtype: Link Rect: 317, 234, 334, 243 ActionDest: 600 Annotation: Subtype: Link Rect: 216, 220, 233, 229 ActionDest: 600 Annotation: Subtype: Link Rect: 301, 178, 318, 187 ActionDest: 600 Annotation: Subtype: Link Rect: 539, 151, 556, 160 ActionDest: 600 Annotation: Subtype: Link Rect: 508, 123, 525, 132 ActionDest: 600 Annotation: Subtype: Link Rect: 474, 95, 491, 104 ActionDest: 600 Annotation: Subtype: Link Rect: 491, 95, 508, 104 ActionDest: 600 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 360, 759, 377, 767 ActionDest: 600 Annotation: Subtype: Link Rect: 464, 730, 481, 740 ActionDest: 600 Annotation: Subtype: Link Rect: 235, 717, 246, 726 ActionDest: 467 Annotation: Subtype: Link Rect: 539, 633, 556, 642 ActionDest: 705 Annotation: Subtype: Link Rect: 330, 577, 342, 586 ActionDest: 467 Annotation: Subtype: Link Rect: 246, 522, 263, 531 ActionDest: 705 Annotation: Subtype: Link Rect: 204, 494, 221, 503 ActionDest: 705 Annotation: Subtype: Link Rect: 224, 494, 241, 503 ActionDest: 705 Annotation: Subtype: Link Rect: 501, 494, 518, 503 ActionDest: 705 Annotation: Subtype: Link Rect: 518, 494, 535, 503 ActionDest: 705 Annotation: Subtype: Link Rect: 538, 494, 555, 503 ActionDest: 705 Annotation: Subtype: Link Rect: 416, 480, 433, 489 ActionDest: 705 Annotation: Subtype: Link Rect: 413, 368, 429, 377 ActionDest: 705 Annotation: Subtype: Link Rect: 478, 368, 495, 377 ActionDest: 705 Annotation: Subtype: Link Rect: 498, 313, 514, 322 ActionDest: 705 Annotation: Subtype: Link Rect: 214, 299, 226, 308 ActionDest: 467 Annotation: Subtype: Link Rect: 532, 271, 544, 280 ActionDest: 467 Annotation: Subtype: Link Rect: 231, 257, 248, 266 ActionDest: 705 Annotation: Subtype: Link Rect: 490, 173, 507, 182 ActionDest: 705 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 200, 744, 217, 754 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 654, 538, 664 ActionDest: 705 Annotation: Subtype: Link Rect: 512, 632, 529, 641 ActionDest: 705 Annotation: Subtype: Link Rect: 530, 632, 547, 641 ActionDest: 705 Annotation: Subtype: Link Rect: 524, 609, 536, 618 ActionDest: 467 Annotation: Subtype: Link Rect: 521, 592, 538, 601 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 576, 538, 585 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 559, 538, 568 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 542, 538, 551 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 525, 538, 534 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 502, 538, 511 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 479, 538, 488 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 462, 538, 472 ActionDest: 705 Annotation: Subtype: Link Rect: 524, 446, 536, 455 ActionDest: 467 Annotation: Subtype: Link Rect: 524, 429, 536, 438 ActionDest: 467 Annotation: Subtype: Link Rect: 521, 406, 538, 415 ActionDest: 705 Annotation: Subtype: Link Rect: 524, 383, 536, 393 ActionDest: 467 Annotation: Subtype: Link Rect: 521, 361, 538, 370 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 338, 538, 347 ActionDest: 705 Annotation: Subtype: Link Rect: 524, 321, 536, 330 ActionDest: 467 Annotation: Subtype: Link Rect: 521, 305, 538, 314 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 282, 538, 291 ActionDest: 600 Annotation: Subtype: Link Rect: 512, 259, 529, 268 ActionDest: 600 Annotation: Subtype: Link Rect: 530, 259, 547, 268 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 242, 538, 251 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 224, 538, 233 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 201, 538, 210 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 179, 538, 188 ActionDest: 600 Annotation: Subtype: Link Rect: 521, 162, 538, 171 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 139, 538, 148 ActionDest: 705 Annotation: Subtype: Link Rect: 521, 110, 538, 119 ActionDest: 600 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 268, 686, 280, 695 ActionDest: 81 Annotation: Subtype: Link Rect: 280, 686, 297, 695 ActionDest: 705 Annotation: Subtype: Link Rect: 539, 658, 556, 667 ActionDest: 705 Annotation: Subtype: Link Rect: 374, 588, 391, 597 ActionDest: 705 Annotation: Subtype: Link Rect: 450, 561, 462, 569 ActionDest: 81 Annotation: Subtype: Link Rect: 413, 533, 429, 542 ActionDest: 705 Annotation: Subtype: Link Rect: 212, 491, 229, 500 ActionDest: 705 Annotation: Subtype: Link Rect: 255, 435, 272, 444 ActionDest: 705 Annotation: Subtype: Link Rect: 272, 435, 289, 444 ActionDest: 705 Annotation: Subtype: Link Rect: 549, 405, 556, 417 ActionDest: 449 Annotation: Subtype: Link Rect: 262, 351, 274, 361 ActionDest: 467 Annotation: Subtype: Link Rect: 277, 351, 289, 361 ActionDest: 467 Annotation: Subtype: Link Rect: 234, 338, 246, 347 ActionDest: 467 Annotation: Subtype: Link Rect: 422, 324, 434, 333 ActionDest: 467 Annotation: Subtype: Link Rect: 490, 296, 502, 305 ActionDest: 467 Annotation: Subtype: Link Rect: 505, 296, 517, 305 ActionDest: 467 Annotation: Subtype: Link Rect: 517, 296, 529, 305 ActionDest: 467 Annotation: Subtype: Link Rect: 530, 296, 542, 305 ActionDest: 467 Annotation: Subtype: Link Rect: 199, 268, 211, 277 ActionDest: 467 Annotation: Subtype: Link Rect: 214, 268, 226, 277 ActionDest: 467 Annotation: Subtype: Link Rect: 259, 254, 276, 263 ActionDest: 705 Annotation: Subtype: Link Rect: 276, 254, 293, 263 ActionDest: 705 Annotation: Subtype: Link Rect: 518, 212, 535, 221 ActionDest: 705 Annotation: Subtype: Link Rect: 195, 168, 202, 180 ActionDest: 67 Annotation: Subtype: Link Rect: 300, 156, 316, 166 ActionDest: 600 Annotation: Subtype: Link Rect: 317, 156, 334, 166 ActionDest: 600 Annotation: Subtype: Link Rect: 293, 143, 310, 152 ActionDest: 600 Annotation: Subtype: Link Rect: 311, 143, 328, 152 ActionDest: 600 Annotation: Subtype: Link Rect: 309, 129, 326, 138 ActionDest: 600 Annotation: Subtype: Link Rect: 388, 101, 405, 110 ActionDest: 705 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 464, 758, 476, 767 ActionDest: 467 Annotation: Subtype: Link Rect: 506, 731, 523, 740 ActionDest: 600 Annotation: Subtype: Link Rect: 344, 703, 361, 712 ActionDest: 705 Annotation: Subtype: Link Rect: 191, 591, 203, 600 ActionDest: 467 Annotation: Subtype: Link Rect: 206, 591, 218, 600 ActionDest: 467 Annotation: Subtype: Link Rect: 218, 591, 230, 600 ActionDest: 467 Annotation: Subtype: Link Rect: 231, 591, 243, 600 ActionDest: 467 Annotation: Subtype: Link Rect: 211, 522, 228, 531 ActionDest: 705 Annotation: Subtype: Link Rect: 228, 522, 245, 531 ActionDest: 705 Annotation: Subtype: Link Rect: 246, 522, 263, 531 ActionDest: 705 Annotation: Subtype: Link Rect: 445, 452, 462, 461 ActionDest: 705 Annotation: Subtype: Link Rect: 343, 410, 359, 419 ActionDest: 705 Annotation: Subtype: Link Rect: 423, 410, 440, 419 ActionDest: 705 Annotation: Subtype: Link Rect: 381, 368, 398, 377 ActionDest: 705 Annotation: Subtype: Link Rect: 371, 282, 378, 294 ActionDest: 824 Annotation: Subtype: Link Rect: 199, 229, 216, 238 ActionDest: 833 Annotation: Subtype: Link Rect: 371, 199, 378, 211 ActionDest: 824 Annotation: Subtype: Link Rect: 215, 157, 222, 169 ActionDest: 57 Annotation: Subtype: Link Rect: 503, 132, 520, 141 ActionDest: 833 Annotation: Subtype: Link Rect: 539, 104, 556, 113 ActionDest: 833 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 222, 759, 239, 767 ActionDest: 600 Annotation: Subtype: Link Rect: 291, 703, 302, 712 ActionDest: 467 Annotation: Subtype: Link Rect: 303, 703, 320, 712 ActionDest: 705 Annotation: Subtype: Link Rect: 323, 703, 340, 712 ActionDest: 705 Annotation: Subtype: Link Rect: 220, 672, 227, 684 ActionDest: 626 Annotation: Subtype: Link Rect: 224, 647, 241, 656 ActionDest: 600 Annotation: Subtype: Link Rect: 241, 82, 258, 91 ActionDest: 833 Page: Sequence: 21 Page: Sequence: 22 Page: Sequence: 23 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 262, 663, 300, 674 Annotation: Subtype: Link Rect: 492, 650, 560, 661 Annotation: Subtype: Link Rect: 56, 637, 143, 648 Annotation: Subtype: Link Rect: 381, 574, 418, 585 Annotation: Subtype: Link Rect: 204, 549, 242, 559 Annotation: Subtype: Link Rect: 118, 523, 155, 534 Annotation: Subtype: Link Rect: 376, 497, 414, 508 Annotation: Subtype: Link Rect: 248, 472, 285, 483 Annotation: Subtype: Link Rect: 104, 447, 141, 457 Annotation: Subtype: Link Rect: 497, 433, 535, 444 Annotation: Subtype: Link Rect: 181, 383, 219, 393 Annotation: Subtype: Link Rect: 59, 332, 96, 342 Annotation: Subtype: Link Rect: 444, 306, 482, 317 Annotation: Subtype: Link Rect: 475, 280, 513, 291 Annotation: Subtype: Link Rect: 293, 255, 331, 265 Annotation: Subtype: Link Rect: 393, 229, 430, 240 Annotation: Subtype: Link Rect: 502, 216, 539, 227 Annotation: Subtype: Link Rect: 512, 152, 550, 163 Annotation: Subtype: Link Rect: 59, 102, 96, 112 Annotation: Subtype: Link Rect: 365, 76, 403, 87 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 236, 718, 274, 729 Annotation: Subtype: Link Rect: 302, 692, 339, 703 Annotation: Subtype: Link Rect: 117, 655, 155, 665 Annotation: Subtype: Link Rect: 492, 628, 530, 639 Annotation: Subtype: Link Rect: 328, 603, 366, 614 Annotation: Subtype: Link Rect: 59, 578, 96, 588 Annotation: Subtype: Link Rect: 480, 565, 517, 576 Annotation: Subtype: Link Rect: 104, 527, 141, 537 Annotation: Subtype: Link Rect: 310, 488, 347, 499 Annotation: Subtype: Link Rect: 478, 462, 516, 473 Annotation: Subtype: Link Rect: 221, 438, 259, 448 Annotation: Subtype: Link Rect: 514, 411, 551, 422 Annotation: Subtype: Link Rect: 173, 374, 210, 384 Annotation: Subtype: Link Rect: 515, 347, 553, 358 Annotation: Subtype: Link Rect: 429, 322, 467, 333 Annotation: Subtype: Link Rect: 308, 296, 346, 307 Annotation: Subtype: Link Rect: 487, 284, 525, 295 Annotation: Subtype: Link Rect: 520, 258, 557, 269 Annotation: Subtype: Link Rect: 177, 233, 215, 244 Annotation: Subtype: Link Rect: 355, 207, 392, 218 Annotation: Subtype: Link Rect: 520, 194, 557, 205 Annotation: Subtype: Link Rect: 516, 182, 554, 193 Annotation: Subtype: Link Rect: 59, 144, 96, 154 Annotation: Subtype: Link Rect: 380, 118, 418, 129 Annotation: Subtype: Link Rect: 289, 92, 326, 103 Annotation: Subtype: Link Rect: 275, 67, 313, 78 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 59, 731, 96, 742 Annotation: Subtype: Link Rect: 396, 705, 434, 716 Annotation: Subtype: Link Rect: 109, 680, 146, 690 Annotation: Subtype: Link Rect: 363, 654, 400, 665 Annotation: Subtype: Link Rect: 293, 628, 331, 639 Annotation: Subtype: Link Rect: 410, 604, 447, 614 Annotation: Subtype: Link Rect: 143, 578, 181, 588 Annotation: Subtype: Link Rect: 59, 540, 96, 550 Annotation: Subtype: Link Rect: 131, 502, 168, 512 Annotation: Subtype: Link Rect: 414, 488, 452, 499 Annotation: Subtype: Link Rect: 306, 462, 343, 473 Annotation: Subtype: Link Rect: 451, 437, 488, 448 Annotation: Subtype: Link Rect: 512, 411, 549, 422 Annotation: Subtype: Link Rect: 455, 386, 493, 397 Annotation: Subtype: Link Rect: 256, 361, 294, 371 Annotation: Subtype: Link Rect: 214, 335, 251, 346 Annotation: Subtype: Link Rect: 312, 309, 350, 320 Annotation: Subtype: Link Rect: 345, 284, 382, 295 Annotation: Subtype: Link Rect: 367, 258, 405, 269 Annotation: Subtype: Link Rect: 373, 194, 410, 205 Annotation: Subtype: Link Rect: 443, 169, 481, 180 Annotation: Subtype: Link Rect: 383, 143, 420, 154 Annotation: Subtype: Link Rect: 109, 106, 146, 116 Annotation: Subtype: Link Rect: 59, 80, 96, 90 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 186, 744, 224, 754 Annotation: Subtype: Link Rect: 351, 718, 389, 729 Annotation: Subtype: Link Rect: 59, 680, 96, 690 Annotation: Subtype: Link Rect: 422, 654, 459, 665 Annotation: Subtype: Link Rect: 214, 616, 251, 627 Annotation: Subtype: Link Rect: 383, 590, 421, 601 Annotation: Subtype: Link Rect: 269, 565, 306, 576 Annotation: Subtype: Link Rect: 108, 540, 146, 550 Annotation: Subtype: Link Rect: 459, 513, 497, 524 Annotation: Subtype: Link Rect: 163, 488, 200, 499 Annotation: Subtype: Link Rect: 476, 462, 514, 473 Annotation: Subtype: Link Rect: 508, 437, 545, 448 Annotation: Subtype: Link Rect: 518, 411, 555, 422 Annotation: Subtype: Link Rect: 263, 373, 300, 384 Annotation: Subtype: Link Rect: 171, 336, 208, 346 Annotation: Subtype: Link Rect: 90, 297, 128, 307 Annotation: Subtype: Link Rect: 59, 259, 96, 269 Annotation: Subtype: Link Rect: 508, 233, 545, 244 Annotation: Subtype: Link Rect: 150, 195, 188, 205 Annotation: Subtype: Link Rect: 392, 130, 430, 141 Annotation: Subtype: Link Rect: 480, 105, 517, 116 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 184, 692, 222, 703 Annotation: Subtype: Link Rect: 407, 667, 444, 678 Annotation: Subtype: Link Rect: 453, 641, 490, 652 Annotation: Subtype: Link Rect: 144, 604, 182, 614 Annotation: Subtype: Link Rect: 511, 577, 548, 588 Annotation: Subtype: Link Rect: 284, 553, 322, 563 Annotation: Subtype: Link Rect: 347, 527, 385, 537 Annotation: Subtype: Link Rect: 113, 489, 151, 499 Annotation: Subtype: Link Rect: 371, 462, 408, 473 Annotation: Subtype: Link Rect: 148, 437, 186, 448 Annotation: Subtype: Link Rect: 350, 411, 387, 422 Annotation: Subtype: Link Rect: 236, 348, 274, 358 Annotation: Subtype: Link Rect: 403, 322, 440, 333 Annotation: Subtype: Link Rect: 390, 296, 427, 307 Annotation: Subtype: Link Rect: 481, 271, 518, 282 Annotation: Subtype: Link Rect: 190, 233, 227, 244 Annotation: Subtype: Link Rect: 108, 195, 146, 205 Annotation: Subtype: Link Rect: 389, 169, 427, 180 Annotation: Subtype: Link Rect: 483, 143, 521, 154 Annotation: Subtype: Link Rect: 492, 118, 530, 129 Annotation: Subtype: Link Rect: 113, 80, 150, 90 Page: Sequence: 29 Annotations: Annotation: Subtype: Link Rect: 59, 731, 96, 742 Annotation: Subtype: Link Rect: 497, 705, 534, 716 Annotation: Subtype: Link Rect: 335, 679, 372, 690 Annotation: Subtype: Link Rect: 293, 654, 330, 665 Annotation: Subtype: Link Rect: 445, 628, 483, 639 Annotation: Subtype: Link Rect: 277, 603, 315, 614 Annotation: Subtype: Link Rect: 439, 577, 477, 588 Annotation: Subtype: Link Rect: 345, 552, 382, 563 Annotation: Subtype: Link Rect: 135, 527, 173, 537 Annotation: Subtype: Link Rect: 312, 502, 349, 512 Annotation: Subtype: Link Rect: 249, 475, 287, 486 Annotation: Subtype: Link Rect: 397, 450, 434, 461 Annotation: Subtype: Link Rect: 59, 412, 96, 422 Annotation: Subtype: Link Rect: 348, 386, 386, 397 Annotation: Subtype: Link Rect: 275, 360, 313, 371 Annotation: Subtype: Link Rect: 99, 336, 137, 346 Annotation: Subtype: Link Rect: 285, 296, 322, 307 Annotation: Subtype: Link Rect: 517, 245, 555, 256 Annotation: Subtype: Link Rect: 340, 220, 377, 231 Annotation: Subtype: Link Rect: 453, 194, 491, 205 Annotation: Subtype: Link Rect: 507, 169, 544, 180 Annotation: Subtype: Link Rect: 122, 131, 159, 141 Annotation: Subtype: Link Rect: 204, 92, 242, 103 Annotation: Subtype: Link Rect: 497, 67, 535, 78 Page: Sequence: 30 Annotations: Annotation: Subtype: Link Rect: 289, 743, 326, 754 Annotation: Subtype: Link Rect: 362, 705, 400, 716 Annotation: Subtype: Link Rect: 382, 679, 420, 690 Annotation: Subtype: Link Rect: 59, 642, 96, 652 Checksum: ed13acf5 Type: CRC32 Checksum: ac0e331b3141a523c5986e58fdfcb503 Type: MD5 Checksum: fc6b6e008117194707565981fdfe6e3fec9fb938 Type: SHA-1 Checksum: 29ac92344cbcd807212249141a73b3f5b26577346d30f18e7e766eb5dae4e00d Type: SHA-256