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Title:           POINTER: study protocol for a phase 2b, randomised, placebo-controlled, double-blind, parallel group dose-finding clinical study to evaluate the efficacy of RMC-035 on renal function and safety, in participants at high risk for kidney injury, following open-chest cardiac surgery
Subject:         Trials, https://doi.org/10.1186/s13063-025-09124-x
Keywords:        Acute kidney injury;AKI;Cardiopulmonary bypass;Ischemia–reperfusion injury;IRI;Alpha-1-microglobulin;A1M;Major adverse kidney events;MAKE
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     Item: 
      Title: POINTER: study protocol for a phase 2b, randomised, placebo-controlled, double-blind, parallel group dose-finding clinical study to evaluate the efficacy of RMC-035 on renal function and safety, in participants at high risk for kidney injury, following op
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Discussion 
         Item: 
          Title: Trial registration 
       Item: 
        Title: Administrative information
       Item: 
        Title: Introduction
        Children: 
         Item: 
          Title: Background and rationale {6a}
         Item: 
          Title: Objectives {7}
         Item: 
          Title: Trial design {8}
       Item: 
        Title: Methods: participants, interventions and outcomes
        Children: 
         Item: 
          Title: Study setting {9}
         Item: 
          Title: Eligibility criteria {10}
         Item: 
          Title: Who will take informed consent? {26a}
         Item: 
          Title: Additional consent provisions for collection and use of participant data and biological specimens {26b}
       Item: 
        Title: Interventions
        Children: 
         Item: 
          Title: Explanation for the choice of comparators {6b}
         Item: 
          Title: Intervention description {11a}
         Item: 
          Title: Criteria for discontinuing or modifying allocated interventions {11b}
         Item: 
          Title: Strategies to improve adherence to interventions {11c}
         Item: 
          Title: Relevant concomitant care permitted or prohibited during the trial {11d}
         Item: 
          Title: Provisions for post-trial care {30}
         Item: 
          Title: Outcomes {12}
          Children: 
           Item: 
            Title: Primary endpoint
           Item: 
            Title: Key secondary endpoints
           Item: 
            Title: Other secondary endpoints
           Item: 
            Title: Exploratory endpoints
           Item: 
            Title: Safety endpoints
         Item: 
          Title: Participant timeline {13}
         Item: 
          Title: Sample size {14}
         Item: 
          Title: Recruitment {15}
       Item: 
        Title: Assignment of interventions: allocation
        Children: 
         Item: 
          Title: Sequence generation {16a}
         Item: 
          Title: Concealment mechanism {16b}
         Item: 
          Title: Implementation {16c}
       Item: 
        Title: Assignment of interventions: blinding
        Children: 
         Item: 
          Title: Who will be blinded {17a}
         Item: 
          Title: Procedure for unblinding if needed {17b}
       Item: 
        Title: Data collection and management
        Children: 
         Item: 
          Title: Plans for assessment and collection of outcomes {18a}
         Item: 
          Title: Plans to promote participant retention and complete follow-up {18b}
         Item: 
          Title: Data management {19}
         Item: 
          Title: Confidentiality {27}
         Item: 
          Title: Plans for collection, laboratory evaluation and storage of biological specimens for genetic or molecular analysis in this trialfuture use {33}
       Item: 
        Title: Statistical methods
        Children: 
         Item: 
          Title: Statistical methods for primary and secondary outcomes {20a}
          Children: 
           Item: 
            Title: Primary endpoint (main analytical approach)
           Item: 
            Title: Key secondary endpoints (man analytical approach)
           Item: 
            Title: Other secondary endpoints and exploratory endpoints
           Item: 
            Title: Safety endpoints
         Item: 
          Title: Interim analyses {21b}
         Item: 
          Title: Methods for additional analyses (e.g. subgroup analyses) {20b}
          Children: 
           Item: 
            Title: Primary endpoint (sensitivity analyses)
           Item: 
            Title: Key secondary endpoints (sensitivity analyses)
         Item: 
          Title: Methods in analysis to handle protocol non-adherence and any statistical methods to handle missing data {20c}
         Item: 
          Title: Plans to give access to the full protocol, participant level-data and statistical code {31c}
       Item: 
        Title: Oversight and monitoring
        Children: 
         Item: 
          Title: Composition of the coordinating centre and trial steering committee {5d}
         Item: 
          Title: Composition of the data monitoring committee, its role and reporting structure {21a}
         Item: 
          Title: Adverse event reporting and harms {22}
         Item: 
          Title: Frequency and plans for auditing trial conduct {23}
         Item: 
          Title: Plans for communicating important protocol amendments to relevant parties (e.g. trial participants, ethical committees) {25}
       Item: 
        Title: Dissemination plans {31a}
       Item: 
        Title: Discussion
       Item: 
        Title: Trial status
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
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                  pdfaProperty:description="This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary."
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). "
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version."
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Volume number"
                  pdfaProperty:name="volume"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Issue number"
                  pdfaProperty:name="number"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Starting page"
                  pdfaProperty:name="startingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Ending page"
                  pdfaProperty:name="endingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. "
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                <rdf:li
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                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”"
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                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright"
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
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              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
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                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
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              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
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                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="DocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
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          <rdf:li>
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              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
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              <rdf:Seq>
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                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
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                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
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          <rdf:li>
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              pdfaSchema:schema="Springer Nature ORCID Schema"
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn">
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                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."/>
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                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author.">
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                        pdfaField:name="name"
                        pdfaField:valueType="Text"
                        pdfaField:description="Gives the name of an author."/>
                      <rdf:li
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"
                        pdfaField:description="Gives the ORCID of an author."/>
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