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IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Body mass index and blood volume influence plasma biomarkers and positron emission tomography classification in preclinical Alzheimer’s disease Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Participant data Destination: subsection..1.2.1 Item: Title: 2.2 | BBM quantification Destination: subsection..1.2.2 Item: Title: 2.3 | Amyloid PET Destination: subsection..1.2.3 Item: Title: 2.4 | Cognitive status Destination: subsection..1.2.4 Item: Title: 2.5 | BMI and BV calculations Destination: subsection..1.2.5 Item: Title: 2.6 | Statistical analysis Destination: subsection..1.2.6 Children: Item: Title: 2.6.1 | Continuous associations between BMI/BV and BBMs Destination: subsubsection..1.2.6.1 Item: Title: 2.6.2 | Associations between BBMs and amyloid PET SUVR Destination: subsubsection..1.2.6.2 Item: Title: 2.6.3 | Modification of BBM-PET SUVR associations by BMI and BV Destination: subsubsection..1.2.6.3 Item: Title: 2.6.4 | Associations between BBMs and amyloid PET positivity Destination: subsubsection..1.2.6.4 Item: Title: 2.6.5 | Influence of BMI and BV when determining BBM cutoff thresholds for PET positivity Destination: subsubsection..1.2.6.5 Item: Title: 2.6.6 | Changes in BMI and BV over time, and their associations with changes in BBMs Destination: subsubsection..1.2.6.6 Item: Title: 2.6.7 | Impact of drastic declines in BMI and BV on PET prediction accuracy Destination: subsubsection..1.2.6.7 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Cohort characteristics Destination: subsection..1.3.1 Item: Title: 3.2 | Continuous associations between BMI/BV and BBMs Destination: subsection..1.3.2 Item: Title: 3.3 | Associations between BBMs and amyloid PET SUVR Destination: subsection..1.3.3 Item: Title: 3.4 | Modification of BBM-PET SUVR associations by BMI and BV Destination: subsection..1.3.4 Item: Title: 3.5 | Associations between BBMs and amyloid PET positivity Destination: subsection..1.3.5 Item: Title: 3.6 | Influence of BMI and BV when determining BBM cutoff thresholds for PET positivity Destination: subsection..1.3.6 Item: Title: 3.7 | Changes in BMI and BV over time, and their associations with changes in BBMs Destination: subsection..1.3.7 Item: Title: 3.8 | Impact of drastic declines in BMI and BV on PET prediction accuracy Destination: subsection..1.3.8 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: 5 | CONCLUSION Destination: section..1.5 Item: Title: CONSENT STATEMENT Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.10 Item: Title: ETHICS APPROVAL AND CONSENT TO PARTICIPATE Destination: section*.12 Item: Title: ORCID Destination: section*.14 Item: Title: REFERENCES Destination: section*.16 Item: Title: SUPPORTING INFORMATION Destination: section*.18 Info: Title: Body mass index and blood volume influence plasma biomarkers and positron emission tomography classification in preclinical Alzheimer's disease Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Oct 11 08:59:39 CEST 2025 ModDate: Sat Oct 11 09:00:22 CEST 2025 ID: 0xf8ce25225ef6ee5ddf64c656078ac134, 0xcc4c28d9b4520bac1eb7e3f8f3dadc64 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 1403 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2050 ImageHeight: 1197 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: 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